KEGG   PATHWAY: ko02020Help
Entry
ko02020                     Pathway                                

Name
Two-component system
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Two-component system
ko02020

All organismsOrtholog table
Module
M00314  
Bacitracin transport system [PATH:ko02020]
M00315  
Uncharacterized ABC transport system [PATH:ko02020]
M00316  
Manganese transport system [PATH:ko02020]
M00434  
PhoR-PhoB (phosphate starvation response) two-component regulatory system [PATH:ko02020]
M00443  
SenX3-RegX3 (phosphate starvation response) two-component regulatory system [PATH:ko02020]
M00444  
PhoQ-PhoP (magnesium transport) two-component regulatory system [PATH:ko02020]
M00445  
EnvZ-OmpR (osmotic stress response) two-component regulatory system [PATH:ko02020]
M00446  
RstB-RstA two-component regulatory system [PATH:ko02020]
M00447  
CpxA-CpxR (envelope stress response) two-component regulatory system [PATH:ko02020]
M00448  
CssS-CssR (secretion stress response) two-component regulatory system [PATH:ko02020]
M00449  
CreC-CreB (phosphate regulation) two-component regulatory system [PATH:ko02020]
M00450  
BaeS-BaeR (envelope stress response) two-component regulatory system [PATH:ko02020]
M00451  
BasS-BasR (antimicrobial peptide resistance) two-component regulatory system [PATH:ko02020]
M00452  
CusS-CusR (copper tolerance) two-component regulatory system [PATH:ko02020]
M00453  
QseC-QseB (quorum sensing) two-component regulatory system [PATH:ko02020]
M00454  
KdpD-KdpE (potassium transport) two-component regulatory system [PATH:ko02020]
M00455  
TorS-TorR (TMAO respiration) two-component regulatory system [PATH:ko02020]
M00456  
ArcB-ArcA (anoxic redox control) two-component regulatory system [PATH:ko02020]
M00457  
TctE-TctD (tricarboxylic acid transport) two-component regulatory system [PATH:ko02020]
M00458  
ResE-ResD (aerobic and anaerobic respiration) two-component regulatory system [PATH:ko02020]
M00459  
VicK-VicR (cell wall metabolism) two-component regulatory system [PATH:ko02020]
M00460  
MprB-MprA (maintenance of persistent infection) two-component regulatory system [PATH:ko02020]
M00461  
MtrB-MtrA (osmotic stress response) two-component regulatory system [PATH:ko02020]
M00462  
PrrB-PrrA (intracellular multiplication) two-component regulatory system [PATH:ko02020]
M00463  
TrcS-TrcR two-component regulatory system [PATH:ko02020]
M00464  
NrsS-NrsR (nickel tolerance) two-component regulatory system [PATH:ko02020]
M00465  
ManS-ManR (manganese homeostasis) two-component regulatory system [PATH:ko02020]
M00466  
NblS-NblR (photosynthesis) two-component regulatory system [PATH:ko02020]
M00467  
SasA-RpaAB (circadian timing mediating) two-component regulatory system [PATH:ko02020]
M00468  
SaeS-SaeR (staphylococcal virulence regulation) two-component regulatory system [PATH:ko02020]
M00469  
BceS-BceR (bacitracin transport) two-component regulatory system [PATH:ko02020]
M00470  
YxdK-YxdJ (antimicrobial peptide response) two-component regulatory system [PATH:ko02020]
M00471  
NarX-NarL (nitrate respiration) two-component regulatory system [PATH:ko02020]
M00472  
NarQ-NarP (nitrate respiration) two-component regulatory system [PATH:ko02020]
M00473  
UhpB-UhpA (hexose phosphates uptake) two-component regulatory system [PATH:ko02020]
M00474  
RcsC-RcsD-RcsB (capsule synthesis) two-component regulatory system [PATH:ko02020]
M00475  
BarA-UvrY (central carbon metabolism) two-component regulatory system [PATH:ko02020]
M00476  
ComP-ComA (competence) two-component regulatory system [PATH:ko02020]
M00477  
EvgS-EvgA (acid and drug tolerance) two-component regulatory system [PATH:ko02020]
M00478  
DegS-DegU (multicellular behavior control) two-component regulatory system [PATH:ko02020]
M00479  
DesK-DesR (membrane lipid fluidity regulation) two-component regulatory system [PATH:ko02020]
M00480  
VraS-VraR (cell-wall peptidoglycan synthesis) two-component regulatory system [PATH:ko02020]
M00481  
LiaS-LiaR (cell wall stress response) two-component regulatory system [PATH:ko02020]
M00482  
DevS-DevR (redox response) two-component regulatory system [PATH:ko02020]
M00483  
NreB-NreC (dissimilatory nitrate/nitrite reduction) two-component regulatory system [PATH:ko02020]
M00484  
YdfH-YdfI two-component regulatory system [PATH:ko02020]
M00485  
KinABCDE-Spo0FA (sporulation control) two-component regulatory system [PATH:ko02020]
M00486  
CitA-CitB (citrate fermentation) two-component regulatory system [PATH:ko02020]
M00487  
CitS-CitT (magnesium-citrate transport) two-component regulatory system [PATH:ko02020]
M00488  
DcuS-DcuR (C4-dicarboxylate metabolism) two-component regulatory system [PATH:ko02020]
M00489  
DctS-DctR (C4-dicarboxylate transport) two-component regulatory system [PATH:ko02020]
M00490  
MalK-MalR (malate transport) two-component regulatory system [PATH:ko02020]
M00492  
LytS-LytR two-component regulatory system [PATH:ko02020]
M00493  
AlgZ-AlgR (alginate production) two-component regulatory system [PATH:ko02020]
M00494  
NatK-NatR (sodium extrusion) two-component regulatory system [PATH:ko02020]
M00495  
AgrC-AgrA (exoprotein synthesis) two-component regulatory system [PATH:ko02020]
M00496  
ComD-ComE (competence) two-component regulatory system [PATH:ko02020]
M00497  
GlnL-GlnG (nitrogen regulation) two-component regulatory system [PATH:ko02020]
M00498  
NtrY-NtrX (nitrogen regulation) two-component regulatory system [PATH:ko02020]
M00499  
HydH-HydG (metal tolerance) two-component regulatory system [PATH:ko02020]
M00500  
AtoS-AtoC (cPHB biosynthesis) two-component regulatory system [PATH:ko02020]
M00501  
PilS-PilR (type 4 fimbriae synthesis) two-component regulatory system [PATH:ko02020]
M00502  
GlrK-GlrR (amino sugar metabolism) two-component regulatory system [PATH:ko02020]
M00503  
PgtB-PgtA (phosphoglycerate transport) two-component regulatory system [PATH:ko02020]
M00504  
DctB-DctD (C4-dicarboxylate transport) two-component regulatory system [PATH:ko02020]
M00505  
KinB-AlgB (alginate production) two-component regulatory system [PATH:ko02020]
M00506  
CheA-CheYBV (chemotaxis) two-component regulatory system [PATH:ko02020]
M00507  
ChpA-ChpB/PilGH (chemosensory) two-component regulatory system [PATH:ko02020]
M00508  
PixL-PixGH (positive phototaxis) two-component regulatory system [PATH:ko02020]
M00509  
WspE-WspRF (chemosensory) two-component regulatory system [PATH:ko02020]
M00510  
Cph1-Rcp1 (light response) two-component regulatory system [PATH:ko02020]
M00511  
PleC-PleD (cell fate control) two-component regulatory system [PATH:ko02020]
M00512  
CckA-CtrA/CpdR (cell cycle control) two-component regulatory system [PATH:ko02020]
M00513  
LuxQN/CqsS-LuxU-LuxO (quorum sensing) two-component regulatory system [PATH:ko02020]
M00514  
TtrS-TtrR (tetrathionate respiration) two-component regulatory system [PATH:ko02020]
M00515  
FlrB-FlrC (polar flagellar synthesis) two-component regulatory system [PATH:ko02020]
M00516  
SLN1-YPD1-SSK1/SKN7 (osmosensing) two-component regulatory system [PATH:ko02020]
M00517  
RpfC-RpfG (cell-to-cell signaling) two-component regulatory system [PATH:ko02020]
M00518  
GlnK-GlnL (glutamine utilization) two-component regulatory system [PATH:ko02020]
M00519  
YesM-YesN two-component regulatory system [PATH:ko02020]
M00520  
ChvG-ChvI (acidity sensing) two-component regulatory system [PATH:ko02020]
M00521  
CiaH-CiaR two-component regulatory system [PATH:ko02020]
M00522  
SalK-SalR two-component regulatory system [PATH:ko02020]
M00523  
RegB-RegA (redox response) two-component regulatory system [PATH:ko02020]
M00524  
FixL-FixJ (nitrogen fixation) two-component regulatory system [PATH:ko02020]
Other DBs
BSID: 
GO: 
Orthology
K07636  
two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
K07657  
two-component system, OmpR family, phosphate regulon response regulator PhoB
K07658  
two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
K01077  
alkaline phosphatase [EC:3.1.3.1]
K01113  
alkaline phosphatase D [EC:3.1.3.1]
K07768  
two-component system, OmpR family, sensor histidine kinase SenX3 [EC:2.7.13.3]
K07776  
two-component system, OmpR family, response regulator RegX3
K02040  
phosphate transport system substrate-binding protein
K07637  
two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
K07660  
two-component system, OmpR family, response regulator PhoP
K07804  
putatice virulence related protein PagC
K07790  
putative membrane protein PagO
K07805  
putative membrane protein PagD
K07801  
hypothetical protein PagK
K08477  
outer membrane protease E [EC:3.4.21.-]
K09474  
acid phosphatase (class A) [EC:3.1.3.2]
K07638  
two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
K07659  
two-component system, OmpR family, phosphate regulon response regulator OmpR
K09475  
outer membrane pore protein C
K09476  
outer membrane pore protein F
K07639  
two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
K07661  
two-component system, OmpR family, response regulator RstA
K07640  
two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3]
K07662  
two-component system, OmpR family, response regulator CpxR
K04771  
serine protease Do [EC:3.4.21.107]
K07650  
two-component system, OmpR family, sensor histidine kinase CssS [EC:2.7.13.3]
K07770  
two-component system, OmpR family, response regulator CssR
K07641  
two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
K07663  
two-component system, OmpR family, catabolic regulation response regulator CreB
K07642  
two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
K07664  
two-component system, OmpR family, response regulator BaeR
K07799  
putative multidrug efflux transporter MdtA
K07788  
RND superfamily, multidrug transport protein MdtB
K07789  
RND superfamily, multidrug transport protein MdtC
K07643  
two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3]
K07771  
two-component system, OmpR family, response regulator BasR
K07806  
UDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase [EC:2.6.1.87]
K07644  
two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
K07665  
two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
K07796  
Cu(I)/Ag(I) efflux system outer membrane protein CusC/SilC
K07810  
Cu(I)/Ag(I) efflux system periplasmic protein CusF
K07798  
Cu(I)/Ag(I) efflux system membrane protein CusB/SilB
K07787  
Cu(I)/Ag(I) efflux system membrane protein CusA/SilA
K07645  
two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
K07666  
two-component system, OmpR family, response regulator QseB
K02403  
flagellar transcriptional activator FlhD
K02402  
flagellar transcriptional activator FlhC
K02406  
flagellin
K02405  
RNA polymerase sigma factor for flagellar operon FliA
K02556  
chemotaxis protein MotA
K07646  
two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
K07667  
two-component system, OmpR family, KDP operon response regulator KdpE
K01546  
K+-transporting ATPase ATPase A chain [EC:3.6.3.12]
K01547  
K+-transporting ATPase ATPase B chain [EC:3.6.3.12]
K01548  
K+-transporting ATPase ATPase C chain [EC:3.6.3.12]
K01545  
K+-transporting ATPase ATPase F chain
K07647  
two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3]
K07772  
two-component system, OmpR family, torCAD operon response regulator TorR
K03532  
trimethylamine-N-oxide reductase (cytochrome c), cytochrome c-type subunit TorC
K07811  
trimethylamine-N-oxide reductase (cytochrome c) [EC:1.7.2.3]
K03533  
TorA specific chaperone
K07648  
two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3]
K07773  
two-component system, OmpR family, aerobic respiration control protein ArcA
K07649  
two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
K07774  
two-component system, OmpR family, response regulator TctD
K07793  
putative tricarboxylic transport membrane protein
K07794  
putative tricarboxylic transport membrane protein
K07795  
putative tricarboxylic transport membrane protein
K07651  
two-component system, OmpR family, sensor histidine kinase ResE [EC:2.7.13.3]
K07775  
two-component system, OmpR family, response regulator ResD
K02259  
cytochrome c oxidase assembly protein subunit 15
K07652  
two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]
K07668  
two-component system, OmpR family, response regulator VicR
K00689  
dextransucrase [EC:2.4.1.5]
K00692  
levansucrase [EC:2.4.1.10]
K07653  
two-component system, OmpR family, sensor histidine kinase MprB [EC:2.7.13.3]
K07669  
two-component system, OmpR family, response regulator MprA
K08372  
putative serine protease PepD [EC:3.4.21.-]
K07654  
two-component system, OmpR family, sensor histidine kinase MtrB [EC:2.7.13.3]
K07670  
two-component system, OmpR family, response regulator MtrA
K02313  
chromosomal replication initiator protein
K07655  
two-component system, OmpR family, sensor histidine kinase PrrB [EC:2.7.13.3]
K07671  
two-component system, OmpR family, response regulator PrrA
K07656  
two-component system, OmpR family, sensor histidine kinase TrcS [EC:2.7.13.3]
K07672  
two-component system, OmpR family, response regulator TrcR
K11328  
two-component system, OmpR family, Ni(II)-sensor and/or redox sensor kinase NrsS [EC:2.7.13.3]
K11330  
two-component system, OmpR family, Ni(II)-responsive and/or redox-responsive regulator NrsR
K11327  
cation efflux system protein involved in nickel and cobalt tolerance
K11326  
cation efflux system protein involved in nickel and cobalt tolerance
K11331  
cation efflux system protein involved in nickel and cobalt tolerance [EC:3.2.1.17]
K07785  
MFS transporter, NRE family, putaive nickel resistance protein
K11520  
two-component system, OmpR family, manganese sensing sensor histidine kinase [EC:2.7.13.3]
K11521  
two-component system, OmpR family, manganese sensing response regulator
K11601  
manganese transport system substrate-binding protein
K11603  
manganese transport system ATP-binding protein
K11602  
manganese transport system permease protein
K07769  
two-component system, OmpR family, sensor histidine kinase NblS [EC:2.7.13.3]
K11332  
two-component system, OmpR family, response regulator NblR
K08479  
two-component system, OmpR family, clock-associated histidine kinase SasA [EC:2.7.13.3]
K10697  
two-component system, OmpR family, response regulator RpaA
K11329  
two-component system, OmpR family, response regulator RpaB
K10681  
two-component system, OmpR family, sensor histidine kinase SaeS [EC:2.7.13.3]
K10682  
two-component system, OmpR family, response regulator SaeR
K11629  
two-component system, OmpR family, bacitracin resistance sensor histidine kinase BceS [EC:2.7.13.3]
K11630  
two-component system, OmpR family, bacitracin resistance response regulator BceR
K11631  
bacitracin transport system ATP-binding protein
K11632  
bacitracin transport system permease protein
K11633  
two-component system, OmpR family, sensor histidine kinase YxdK [EC:2.7.13.3]
K11634  
two-component system, OmpR family, response regulator YxdJ
K11635  
putative ABC transport system ATP-binding protein
K11636  
putative ABC transport system permease protein
K14980  
two-component system, OmpR family, sensor histidine kinase ChvG [EC:2.7.13.3]
K14981  
two-component system, OmpR family, response regulator ChvI
K14982  
two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]
K14983  
two-component system, OmpR family, response regulator CiaR
K15860  
regulatory peptide CiaX
K18072  
two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]
K18073  
two-component system, OmpR family, response regulator ParR
K18093  
imipenem/basic amino acid-specific outer membrane pore [EC:3.4.21.-]
K18094  
membrane fusion protein
K18095  
multidrug efflux pump
K02491  
two-component system, sporulation sensor kinase A [EC:2.7.13.3]
K07697  
two-component system, sporulation sensor kinase B [EC:2.7.13.3]
K06347  
kinase-associated protein B
K07698  
two-component system, sporulation sensor kinase C [EC:2.7.13.3]
K13532  
two-component system, sporulation sensor kinase D [EC:2.7.13.3]
K13533  
two-component system, sporulation sensor kinase E [EC:2.7.13.3]
K02490  
two-component system, response regulator, stage 0 sporulation protein F
K06375  
stage 0 sporulation protein B (sporulation initiation phosphotransferase) [EC:2.7.-.-]
K07699  
two-component system, response regulator, stage 0 sporulation protein A
K07700  
two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3]
K07702  
two-component system, CitB family, response regulator CitB
K01910  
[citrate (pro-3S)-lyase] ligase [EC:6.2.1.22]
K01646  
citrate lyase subunit gamma [EC:4.1.3.6]
K01644  
citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34 4.1.3.6]
K01643  
citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10 4.1.3.6]
K05964  
holo-ACP synthase [EC:2.7.7.61]
K05966  
triphosphoribosyl-dephospho-CoA synthase [EC:2.4.2.52]
K13927  
holo-ACP synthase / triphosphoribosyl-dephospho-CoA synthase [EC:2.4.2.52 2.7.7.61]
K09477  
citrate:succinate antiporter
K07780  
AraC family transcriptional regulator, transcriptional regulator required for anaerobic and stationary phase induction of genes
K11637  
two-component system, CitB family, sensor histidine kinase CitS [EC:2.7.13.3]
K11638  
two-component system, CitB family, response regulator CitT
K11639  
Mg2+/citrate complex secondary transporter
K07701  
two-component system, CitB family, sensor histidine kinase DcuS [EC:2.7.13.3]
K07703  
two-component system, CitB family, response regulator DcuR
K07792  
anaerobic C4-dicarboxylate transporter DcuB
K11691  
two-component system, CitB family, sensor histidine kinase DctS [EC:2.7.13.3]
K11692  
two-component system, CitB family, response regulator DctR
K11614  
two-component system, CitB family, sensor histidine kinase MalK [EC:2.7.13.3]
K11615  
two-component system, CitB family, response regulator MalR
K00027  
malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]
K11616  
malate:Na+ symporter
K07704  
two-component system, LytT family, sensor histidine kinase LytS [EC:2.7.13.3]
K07705  
two-component system, LytT family, response regulator LytT
K05338  
holin-like protein
K05339  
holin-like protein LrgB
K08082  
two-component system, LytT family, sensor histidine kinase AlgZ [EC:2.7.13.3]
K08083  
two-component system, LytT family, response regulator AlgR
K00066  
GDP-mannose 6-dehydrogenase [EC:1.1.1.132]
K11640  
two-component system, LytT family, sensor histidine kinase NatK [EC:2.7.13.3]
K11641  
two-component system, LytT family, response regulator NatR
K09697  
sodium transport system ATP-binding protein
K09696  
sodium transport system permease protein
K07813  
accessory gene regulator B
K07800  
AgrD protein
K07706  
two-component system, AgrA family, sensor histidine kinase AgrC [EC:2.7.13.-]
K07707  
two-component system, AgrA family, response regulator AgrA
K12292  
ATP-binding cassette, subfamily C, bacterial, competence factor transporting protein [EC:3.4.22.-]
K12293  
competence factor transport accessory protein ComB
K12415  
competence-stimulating peptide
K12294  
two-component system, AgrA family, sensor histidine kinase ComD [EC:2.7.13.-]
K12295  
two-component system, AgrA family, response regulator ComE
K12296  
competence protein ComX
K07673  
two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
K07684  
two-component system, NarL family, nitrate/nitrite response regulator NarL
K07674  
two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3]
K07685  
two-component system, NarL family, nitrate/nitrite response regulator NarP
K00370  
nitrate reductase alpha subunit [EC:1.7.99.4]
K00371  
nitrate reductase beta subunit [EC:1.7.99.4]
K00373  
nitrate reductase delta subunit
K00374  
nitrate reductase gamma subunit [EC:1.7.99.4]
K08348  
formate dehydrogenase-N, alpha subunit [EC:1.1.5.6]
K08349  
formate dehydrogenase-N, beta subunit
K08350  
formate dehydrogenase-N, gamma subunit
K00244  
fumarate reductase flavoprotein subunit [EC:1.3.99.1]
K00245  
fumarate reductase iron-sulfur subunit [EC:1.3.99.1]
K00246  
fumarate reductase subunit C
K00247  
fumarate reductase subunit D
K07783  
MFS transporter, OPA family, sugar phosphate sensor protein UhpC
K07675  
two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
K07686  
two-component system, NarL family, uhpT operon response regulator UhpA
K07784  
MFS transporter, OPA family, hexose phosphate transport protein UhpT
K06080  
RcsF protein
K07677  
two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
K07676  
two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3]
K07781  
LuxR family transcriptional regulator, capsular biosynthesis positive transcription factor
K07687  
two-component system, NarL family, captular synthesis response regulator RcsB
K07678  
two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
K07689  
two-component system, NarL family, invasion response regulator UvrY
K07782  
LuxR family transcriptional regulator
K03563  
carbon storage regulator
K02253  
competence protein ComX
K07680  
two-component system, NarL family, sensor histidine kinase ComP [EC:2.7.13.3]
K07691  
two-component system, NarL family, competent response regulator ComA
K02252  
competence protein ComS
K07679  
two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
K07690  
two-component system, NarL family, response regulator EvgA
K07797  
multidrug resistance protein K
K07786  
MFS transporter, multidrug resistance protein Y
K07688  
two-component system, NarL family, response regulator, fimbrial Z protein, FimZ
K01467  
beta-lactamase class C [EC:3.5.2.6]
K07777  
two-component system, NarL family, sensor histidine kinase DegS [EC:2.7.13.3]
K07692  
two-component system, NarL family, response regulator DegU
K07778  
two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]
K07693  
two-component system, NarL family, response regulator DesR
K10255  
omega-6 fatty acid desaturase (delta-12 desaturase) [EC:1.14.19.-]
K07681  
two-component system, NarL family, vancomycin resistance sensor histidine kinase VraS [EC:2.7.13.3]
K07694  
two-component system, NarL family, vancomycin resistance associated response regulator VraR
K11617  
two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
K11618  
two-component system, NarL family, response regulator LiaR
K11619  
lia operon protein LiaI
K11620  
lia operon protein LiaH
K11621  
lia operon protein LiaG
K11622  
lia operon protein LiaF
K07682  
two-component system, NarL family, sensor histidine kinase DevS [EC:2.7.13.3]
K07695  
two-component system, NarL family, response regulator DevR
K07683  
two-component system, NarL family, sensor histidine kinase NreB [EC:2.7.13.3]
K07696  
two-component system, NarL family, response regulator NreC
K10851  
nitrogen regulatory protein A
K10850  
MFS transporter, NNP family, putative nitrate transporter
K11623  
two-component system, NarL family, sensor histidine kinase YdfH [EC:2.7.13.3]
K11624  
two-component system, NarL family, response regulator YdfI
K11625  
membrane protein YdfJ
K00990  
[protein-PII] uridylyltransferase [EC:2.7.7.59]
K04751  
nitrogen regulatory protein P-II 1
K07708  
two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
K07712  
two-component system, NtrC family, nitrogen regulation response regulator GlnG
K01915  
glutamine synthetase [EC:6.3.1.2]
K13598  
two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]
K13599  
two-component system, NtrC family, nitrogen regulation response regulator NtrX
K02584  
Nif-specific regulatory protein
K07709  
two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3]
K07713  
two-component system, NtrC family, response regulator HydG
K07803  
zinc resistance-associated protein
K07710  
two-component system, NtrC family, sensor histidine kinase AtoS [EC:2.7.13.3]
K07714  
two-component system, NtrC family, response regulator AtoC
K01034  
acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.9 2.8.3.8]
K01035  
acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.9 2.8.3.8]
K02106  
short-chain fatty acids transporter
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K08478  
phosphoglycerate transport regulatory protein PgtC
K08475  
two-component system, NtrC family, phosphoglycerate transport system sensor histidine kinase PgtB [EC:2.7.13.3]
K08476  
two-component system, NtrC family, phosphoglycerate transport system response regulator PgtA
K11382  
MFS transporter, OPA family, phosphoglycerate transporter protein
K10125  
two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
K10126  
two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
K11103  
aerobic C4-dicarboxylate transport protein
K02668  
two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]
K02667  
two-component system, NtrC family, response regulator PilR
K03092  
RNA polymerase sigma-54 factor
K02650  
type IV pilus assembly protein PilA
K11383  
two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3]
K11384  
two-component system, NtrC family, response regulator AlgB
K07711  
two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]
K07715  
two-component system, NtrC family, response regulator GlrR
K15841  
small regulatory RNA GlmY
K14988  
two-component system, NarL family, secretion system sensor histidine kinase SalK
K14989  
two-component system, NarL family, secretion system response regulator SalR
K00575  
chemotaxis protein methyltransferase CheR [EC:2.1.1.80]
K13924  
two-component system, chemotaxis family, CheB/CheR fusion protein [EC:3.1.1.61 2.1.1.80]
K03406  
methyl-accepting chemotaxis protein
K05874  
methyl-accepting chemotaxis protein I, serine sensor receptor
K05875  
methyl-accepting chemotaxis protein II, aspartate sensor receptor
K05876  
methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor
K05877  
methyl-accepting chemotaxis protein IV, peptide sensor receptor
K03776  
aerotaxis receptor
K03408  
purine-binding chemotaxis protein CheW
K03407  
two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
K03413  
two-component system, chemotaxis family, response regulator CheY
K03412  
two-component system, chemotaxis family, response regulator CheB [EC:3.1.1.61]
K03415  
two-component system, chemotaxis family, response regulator CheV
K02661  
type IV pilus assembly protein PilK
K02660  
twitching motility protein PilJ
K02659  
twitching motility protein PilI
K06596  
chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
K02487  
type IV pili sensor histidine kinase and response regulator
K02657  
twitching motility two-component system response regulator PilG
K02658  
twitching motility two-component system response regulator PilH
K11525  
methyl-accepting chemotaxis protein PixJ
K11524  
positive phototaxis protein PixI
K11526  
two-component system, chemotaxis family, sensor histidine kinase and response regulator PixL
K11522  
two-component system, chemotaxis family, response regulator PixG
K11523  
two-component system, chemotaxis family, response regulator PixH
K06597  
chemosensory pili system protein ChpB (putative protein-glutamate methylesterase)
K06598  
chemosensory pili system protein ChpC
K13486  
chemotaxis protein methyltransferase WspC
K13487  
methyl-accepting chemotaxis protein WspA
K13488  
chemotaxis-related protein WspB
K13489  
chemotaxis-related protein WspD
K13490  
two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE
K13491  
two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61]
K11444  
two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65]
K11354  
two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3]
K11355  
two-component system, chemotaxis family, response regulator Rcp1
K07716  
two-component system, cell cycle sensor histidine kinase PleC [EC:2.7.13.3]
K02489  
two-component system, cell cycle sensor kinase and response regulator [EC:2.7.13.3]
K02488  
two-component system, cell cycle response regulator
K11357  
two-component system, cell cycle sensor histidine kinase DivJ [EC:2.7.13.3]
K11443  
two-component system, cell cycle response regulator DivK
K13587  
two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3]
K13588  
histidine phosphotransferase ChpT
K13584  
two-component system, cell cycle response regulator CtrA
K13589  
two-component system, cell cycle response regulator CpdR
K10910  
autoinducer 2-binding periplasmic protein LuxP
K10909  
two-component system, autoinducer 2 sensor kinase/phosphatase LuxQ [EC:3.1.3.- 2.7.13.3]
K10916  
two-component system, CAI-1 autoinducer sensor kinase/phosphatase CqsS [EC:3.1.3.- 2.7.13.3]
K15850  
two-component system, autoinducer 1 sensor kinase/phosphatase LuxN [EC:3.1.3.- 2.7.13.3]
K10911  
two-component system, phosphorelay protein LuxU
K10912  
two-component system, repressor protein LuxO
K15851  
quorum regulatory RNA Qrr
K15852  
LuxR family transcriptional regulator, transcriptional activator of the bioluminescence operon
K03400  
long-chain-fatty-acyl-CoA reductase [EC:1.2.1.50]
K15853  
acyl transferase [EC:2.3.1.-]
K00494  
alkanal monooxygenase alpha chain [EC:1.14.14.3]
K15854  
alkanal monooxygenase beta chain [EC:1.14.14.3]
K06046  
long-chain-fatty-acid---luciferin-component ligase [EC:6.2.1.19]
K11711  
two-component system, LuxR family, sensor histidine kinase DctS [EC:2.7.13.3]
K11712  
two-component system, LuxR family, response regulator DctR
K11688  
C4-dicarboxylate-binding protein DctP
K11689  
C4-dicarboxylate transporter, DctQ subunit
K11690  
C4-dicarboxylate transporter, DctM subunit
K13040  
two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3]
K13041  
two-component system, LuxR family, response regulator TtrR
K08357  
tetrathionate reductase subunit A
K08358  
tetrathionate reductase subunit B
K08359  
tetrathionate reductase subunit C
K14986  
two-component system, LuxR family, sensor kinase FixL [EC:2.7.13.3]
K14987  
two-component system, LuxR family, response regulator FixJ
K15861  
CRP/FNR family transcriptional regulator, nitrogen fixation regulation protein
K14978  
two-component system, LuxR family, secretion system sensor histidine kinase SsrA
K14979  
two-component system, LuxR family, secretion system response regulator SsrB
K10941  
sigma-54 specific transcriptional regulator, flagellar regulatory protein A
K10942  
two-component system, sensor histidine kinase FlrB [EC:2.7.13.3]
K10943  
two-component system, response regulator FlrC
K17060  
two-component system, sensor histidine kinase AauS [EC:2.7.13.3]
K17061  
two-component system, response regulator AauR
K10004  
glutamate/aspartate transport system ATP-binding protein [EC:3.6.3.-]
K10002  
glutamate/aspartate transport system permease protein
K10003  
glutamate/aspartate transport system permease protein
K10001  
glutamate/aspartate transport system substrate-binding protein
K05597  
glutamin-(asparagin-)ase [EC:3.5.1.38]
K11231  
osomolarity two-component system, sensor histidine kinase SLN1 [EC:2.7.13.3]
K11232  
osomolarity two-component system, phosphorelay intermediate protein YPD1
K11233  
osomolarity two-component system, response regulator SSK1
K11230  
mitogen-activated protein kinase kinase kinase [EC:2.7.11.25]
K15859  
osomolarity two-component system, response regulator SKN7
K10715  
two-component system, sensor histidine kinase RpfC [EC:2.7.13.3]
K13815  
two-component system, response regulator RpfG
K10914  
CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
K13816  
DSF synthase
K07717  
two-component system, sensor histidine kinase YcbA [EC:2.7.13.3]
K07719  
two-component system, response regulator YcbB
K11626  
putative sodium/glutamine symporter
K07718  
two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
K07720  
two-component system, response regulator YesN
K11356  
two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
K15011  
two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
K15012  
two-component system, response regulator RegA
K08930  
light-harvesting protein B-800-850 alpha chain
K08939  
light-harvesting protein B-800-850 beta chain
K13994  
photosynthetic reaction center PufX protein
K08929  
photosynthetic reaction center M subunit
K08928  
photosynthetic reaction center L subunit
K08926  
light-harvesting complex 1 alpha chain
K08927  
light-harvesting complex 1 beta chain
K13991  
photosynthetic reaction center H subunit
K00411  
ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:1.10.2.2]
K00412  
ubiquinol-cytochrome c reductase cytochrome b subunit
K00413  
ubiquinol-cytochrome c reductase cytochrome c1 subunit
K00410  
ubiquinol-cytochrome c reductase cytochrome b/c1 subunit
K08738  
cytochrome c
K00404  
cytochrome c oxidase cbb3-type subunit I [EC:1.9.3.1]
K00405  
cytochrome c oxidase cbb3-type subunit II
K15862  
cytochrome c oxidase cbb3-type subunit I/II [EC:1.9.3.1]
K00407  
cytochrome c oxidase cbb3-type subunit IV
K00406  
cytochrome c oxidase cbb3-type subunit III
K00425  
cytochrome d ubiquinol oxidase subunit I [EC:1.10.3.-]
K00426  
cytochrome d ubiquinol oxidase subunit II [EC:1.10.3.-]
Compound
C00007  
Oxygen
C00009  
Orthophosphate
C00025  
L-Glutamate
C00031  
D-Glucose
C00034  
Manganese
C00036  
Oxaloacetate
C00038  
Zinc cation
C00042  
Succinate
C00049  
L-Aspartate
C00064  
L-Glutamine
C00070  
Copper
C00088  
Nitrite
C00092  
D-Glucose 6-phosphate
C00122  
Fumarate
C00149  
(S)-Malate
C00158  
Citrate
C00164  
Acetoacetate
C00238  
Potassium cation
C00244  
Nitrate
C00291  
Nickel
C00305  
Magnesium cation
C00399  
Ubiquinone
C00547  
L-Noradrenaline
C00697  
Nitrogen
C00788  
L-Adrenaline
C00828  
Menaquinone
C01104  
Trimethylamine N-oxide
C01667  
Bacitracin
C02084  
Tetrathionate
C05818  
2-Demethylmenaquinone
C06689  
Vancomycin
C06696  
Lead
C11612  
Polymyxin B
C11842  
N-(3-(S)-Hydroxybutyryl)homoserine lactone
C12008  
Ramoplanin A2
C14819  
Fe3+
C16421  
AI-2
C16463  
3',5'-Cyclic diGMP
C16640  
CAI-1
C16665  
12-Methyltetradecanoic acid
C18206  
cis-11-Methyl-2-dodecenoic acid
D07746  
Colistin (INN)
D08401  
Polymyxin B (INN)
Reference
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Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
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Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
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