KEGG PATHWAY: ko03013

PATHWAY: ko03013

Entry

ko03013 Pathway

Name

RNA transport

Description

RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation.

Class

Genetic Information Processing; Translation

Pathway map

ko03013

RNA transport

Module

M00399	Cap binding complex [PATH:ko03013]
M00405	THC complex [PATH:ko03013]
M00406	TREX complex [PATH:ko03013]
M00426	Survival motor neuron (SMN) complex [PATH:ko03013]
M00427	Nuclear pore complex [PATH:ko03013]
M00428	eIF4F complex [PATH:ko03013]
M00430	Exon junction complex (EJC) [PATH:ko03013]

Disease

H00455	Spinal muscular atrophy (SMA)
H00465	Fragile X Syndrome
H00869	Leukoencephalopathy with vanishing white matter
H01177	Infantile bilateral striatal necrosis (IBSN)

Other DBs

BSID:

175229

GO:

0050658

Orthology

K01164	ribonuclease P/MRP protein subunit POP1 [EC:3.1.26.5]
K14522	ribonuclease P/MRP protein subunit POP3 [EC:3.1.26.5]
K14523	ribonucleases P/MRP protein subunit RPP38 [EC:3.1.26.5]
K03538	ribonuclease P protein subunit POP4 [EC:3.1.26.5]
K03537	ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5]
K14524	ribonuclease P/MRP protein subunit POP6 [EC:3.1.26.5]
K14525	ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5]
K14526	ribonuclease P/MRP protein subunit POP7 [EC:3.1.26.5]
K14527	ribonuclease P/MRP protein subunit RPP20 [EC:3.1.26.5]
K14528	ribonuclease P/MRP protein subunit POP8 [EC:3.1.26.5]
K14529	ribonuclease P protein subunit RPP14 [EC:3.1.26.5]
K03539	ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5]
K03540	ribonuclease P protein subunit RPR2 [EC:3.1.26.5]
K14530	ribonucleases P/MRP protein subunit RPP40 [EC:3.1.26.5]
K00784	ribonuclease Z [EC:3.1.26.11]
K00974	tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:3.1.4.- 3.1.3.- 2.7.7.72]
K07936	GTP-binding nuclear protein Ran
K14288	exportin-T
K14289	exportin-5
K03231	elongation factor 1-alpha
K14290	exportin-1
K14291	phosphorylated adapter RNA export protein
K12882	nuclear cap-binding protein subunit 1
K12883	nuclear cap-binding protein subunit 2
K05019	chloride channel, nucleotide-sensitive, 1A
K02516	protein arginine N-methyltransferase 5 [EC:2.1.1.125]
K14292	trimethylguanosine synthase [EC:2.1.1.-]
K14293	importin subunit beta-1
K13151	snurportin-1
K07562	nonsense-mediated mRNA decay protein 3
K14294	partner of Y14 and mago
K09291	nucleoprotein TPR
K14295	nuclear pore complex protein Nup50
K14296	nuclear pore complex protein Nup153
K03345	sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68]
K14297	nuclear pore complex protein Nup98-Nup96
K14298	mRNA export factor
K14004	protein transport protein SEC13
K14299	nucleoporin SEH1
K14300	nuclear pore complex protein Nup133
K14301	nuclear pore complex protein Nup107
K14302	nuclear pore complex protein Nup37
K14303	nuclear pore complex protein Nup160
K14304	nuclear pore complex protein Nup85
K14305	nuclear pore complex protein Nup43
K14306	nuclear pore complex protein Nup62
K14307	nucleoporin p58/p45
K14308	nuclear pore complex protein Nup54
K14309	nuclear pore complex protein Nup93
K14310	nuclear pore complex protein Nup205
K14311	nuclear pore complex protein Nup188
K14312	nuclear pore complex protein Nup155
K14313	nuclear pore complex protein Nup53
K14314	nuclear pore complex protein Nup210
K14315	nucleoporin NDC1
K14316	nuclear pore complex protein Nup121
K14317	nuclear pore complex protein Nup214
K14318	nuclear pore complex protein Nup88
K12172	E3 SUMO-protein ligase RanBP2
K14319	Ran GTPase-activating protein 1
K10577	ubiquitin-conjugating enzyme E2 I [EC:6.3.2.19]
K12160	small ubiquitin-related modifier
K14320	aladin
K14321	nucleoporin-like protein 2
K13129	survival motor neuron protein
K13130	survival of motor neuron protein-interacting protein 1
K13131	ATP-dependent RNA helicase DDX20 [EC:3.6.4.13]
K13132	gem associated protein 4
K13133	gem associated protein 5
K13134	gem associated protein 6
K13135	gem associated protein 7
K13136	gem associated protein 8
K13137	serine-threonine kinase receptor-associated protein
K03245	translation initiation factor 3 subunit J
K03246	translation initiation factor 3 subunit I
K03247	translation initiation factor 3 subunit H
K03248	translation initiation factor 3 subunit G
K03249	translation initiation factor 3 subunit F
K03250	translation initiation factor 3 subunit E
K03251	translation initiation factor 3 subunit D
K03252	translation initiation factor 3 subunit C
K03253	translation initiation factor 3 subunit B
K03254	translation initiation factor 3 subunit A
K03236	translation initiation factor 1A
K03113	translation initiation factor 1
K03262	translation initiation factor 5
K03237	translation initiation factor 2 subunit 1
K03238	translation initiation factor 2 subunit 2
K03242	translation initiation factor 2 subunit 3
K03239	translation initiation factor eIF-2B subunit alpha
K03754	translation initiation factor eIF-2B subunit beta
K03680	translation initiation factor eIF-2B subunit delta
K03241	translation initiation factor eIF-2B subunit gamma
K03240	translation initiation factor eIF-2B subunit epsilon
K03243	translation initiation factor 5B
K03260	translation initiation factor 4G
K03259	translation initiation factor 4E
K03257	translation initiation factor 4A
K03258	translation initiation factor 4B
K13126	polyadenylate-binding protein
K14322	polyadenylate-binding protein-interacting protein 1
K07205	eukaryotic translation initiation factor 4E binding protein 1
K14283	transforming acidic coiled-coil-containing protein 3
K05749	cytoplasmic FMR1 interacting protein
K15516	fragile X mental retardation protein
K12876	RNA-binding protein 8A
K12877	protein mago nashi
K14323	protein CASC3
K13025	ATP-dependent RNA helicase [EC:3.6.4.13]
K14324	histone deacetylase complex subunit SAP18
K13114	pinin
K12875	apoptotic chromatin condensation inducer in the nucleus
K14325	RNA-binding protein with serine-rich domain 1
K12881	THO complex subunit 4
K12812	ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.4.13]
K12878	THO complex subunit 1
K12879	THO complex subunit 2
K13174	THO complex subunit 5
K13175	THO complex subunit 6
K13176	THO complex subunit 7
K12880	THO complex subunit 3
K13171	serine/arginine repetitive matrix protein 1
K14284	nuclear RNA export factor 1/2
K14285	NTF2-related export protein 1/2
K14543	mRNA transport regulator MTR2
K14326	regulator of nonsense transcripts 1 [EC:3.6.4.-]
K14327	regulator of nonsense transcripts 2
K14328	regulator of nonsense transcripts 3
K14276	U1 spliceosomal RNA
K14277	U2 spliceosomal RNA
K14278	U4 spliceosomal RNA
K14279	U5 spliceosomal RNA
K14280	U6 spliceosomal RNA
K14483	U3 small nucleolar RNA

Compound

C00035	GDP
C00044	GTP
C01647	tRNA(Met)

Reference

PMID:15519698

Authors

Rodriguez MS, Dargemont C, Stutz F

Title

Nuclear export of RNA.

Journal

Biol Cell 96:639-55 (2004)

Reference

PMID:20733056

Authors

Suzuki T, Izumi H, Ohno M

Title

Cajal body surveillance of U snRNA export complex assembly.

Journal

J Cell Biol 190:603-12 (2010)

Reference

PMID:18313922

Authors

Palancade B, Doye V

Title

Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?

Journal

Trends Cell Biol 18:174-83 (2008)

Reference

PMID:17401408

Authors

Pellizzoni L

Title

Chaperoning ribonucleoprotein biogenesis in health and disease.

Journal

EMBO Rep 8:340-5 (2007)

Reference

PMID:10872469

Authors

Gingras AC, Raught B, Sonenberg N

Title

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.

Journal

Annu Rev Biochem 68:913-63 (1999)

Reference

PMID:11018020

Authors

Asano K, Clayton J, Shalev A, Hinnebusch AG

Title

A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.

Journal

Genes Dev 14:2534-46 (2000)

Reference

PMID:9548260

Authors

Craig AW, Haghighat A, Yu AT, Sonenberg N

Title

Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.

Journal

Nature 392:520-3 (1998)

Reference

PMID:15901496

Authors

Reed R, Cheng H

Title

TREX, SR proteins and export of mRNA.

Journal

Curr Opin Cell Biol 17:269-73 (2005)

Reference

PMID:16314458

Authors

Tange TO, Shibuya T, Jurica MS, Moore MJ

Title

Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.

Journal

RNA 11:1869-83 (2005)

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Ontology (2)   
   KEGG BRITE (1)   
   GO (1)   
Pathway (10)   
   KEGG PATHWAY (2)   
   KEGG MODULE (7)   
   BioSystems (1)   
Disease (4)   
   KEGG DISEASE (4)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (11)   
   KEGG ENZYME (11)   
Gene (134)   
   KEGG ORTHOLOGY (134)   
Literature (9)   
   PubMed (9)   
All databases (173)   

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