KEGG PATHWAY: ko03015

PATHWAY: ko03015

Entry

ko03015 Pathway

Name

mRNA surveillance pathway

Description

The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.

Class

Genetic Information Processing; Translation

Pathway map

ko03015

mRNA surveillance pathway

Module

M00399	Cap binding complex [PATH:ko03015]
M00430	Exon junction complex (EJC) [PATH:ko03015]

Disease

H00658	Syndromic X-linked mental retardation
H00704	Oculopharyngeal muscular dystrophy (OPMD)

Other DBs

BSID:

193184

GO:

0071028

Orthology

K12882	nuclear cap-binding protein subunit 1
K12883	nuclear cap-binding protein subunit 2
K14328	regulator of nonsense transcripts 3
K12876	RNA-binding protein 8A
K12877	protein mago nashi
K14323	protein CASC3
K13025	ATP-dependent RNA helicase [EC:3.6.4.13]
K14324	histone deacetylase complex subunit SAP18
K13114	pinin
K12875	apoptotic chromatin condensation inducer in the nucleus
K14325	RNA-binding protein with serine-rich domain 1
K12881	THO complex subunit 4
K14284	nuclear RNA export factor 1/2
K14285	NTF2-related export protein 1/2
K14543	mRNA transport regulator MTR2
K12812	ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.4.13]
K14294	partner of Y14 and mago
K13171	serine/arginine repetitive matrix protein 1
K13917	mRNA-capping enzyme [EC:3.1.3.33 2.7.7.50]
K00565	mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]
K14396	polyadenylate-binding protein 2
K14397	cleavage and polyadenylation specificity factor subunit 5
K14398	cleavage and polyadenylation specificity factor subunit 6/7
K14376	poly(A) polymerase [EC:2.7.7.19]
K14399	polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]
K14400	pre-mRNA cleavage complex 2 protein Pcf11
K14401	cleavage and polyadenylation specificity factor subunit 1
K14402	cleavage and polyadenylation specificity factor subunit 2
K14403	cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
K14404	cleavage and polyadenylation specificity factor subunit 4
K14405	pre-mRNA 3'-end-processing factor FIP1
K15541	protein MPE1
K15542	polyadenylation factor subunit 2
K14962	COMPASS component SWD2
K15543	RNA end formation protein 2
K06269	protein phosphatase 1, catalytic subunit [EC:3.1.3.16]
K15544	RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]
K14406	cleavage stimulation factor subunit 1
K14407	cleavage stimulation factor subunit 2
K14408	cleavage stimulation factor subunit 3
K06100	symplekin
K12595	superkiller protein 7
K14411	RNA-binding protein Musashi
K13126	polyadenylate-binding protein
K03265	peptide chain release factor subunit 1
K03267	peptide chain release factor subunit 3
K14326	regulator of nonsense transcripts 1 [EC:3.6.4.-]
K14327	regulator of nonsense transcripts 2
K08873	PI-3-kinase-related kinase SMG-1
K14409	protein SMG7
K11125	protein SMG5
K11124	protein SMG6 [EC:3.1.-.-]
K04382	protein phosphatase 2 (formerly 2A), catalytic subunit [EC:3.1.3.16]
K03456	protein phosphatase 2 (formerly 2A), regulatory subunit A
K04354	protein phosphatase 2 (formerly 2A), regulatory subunit B
K11583	protein phosphatase 2 (formerly 2A), regulatory subunit B''
K11584	protein phosphatase 2 (formerly 2A), regulatory subunit B'
K14416	elongation factor 1 alpha-like protein
K06965	protein pelota

Reference

PMID:15040442

Authors

Maquat LE

Title

Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.

Journal

Nat Rev Mol Cell Biol 5:89-99 (2004)

Reference

PMID:16723977

Authors

Amrani N, Sachs MS, Jacobson A

Title

Early nonsense: mRNA decay solves a translational problem.

Journal

Nat Rev Mol Cell Biol 7:415-25 (2006)

Reference

PMID:17183357

Authors

Eulalio A, Behm-Ansmant I, Izaurralde E

Title

P bodies: at the crossroads of post-transcriptional pathways.

Journal

Nat Rev Mol Cell Biol 8:9-22 (2007)

Reference

PMID:18158581

Authors

Mandel CR, Bai Y, Tong L

Title

Protein factors in pre-mRNA 3'-end processing.

Journal

Cell Mol Life Sci 65:1099-122 (2008)

Reference

PMID:16715045

Authors

Clement SL, Lykke-Andersen J

Title

No mercy for messages that mess with the ribosome.

Journal

Nat Struct Mol Biol 13:299-301 (2006)

All links

Ontology (2)   
   KEGG BRITE (1)   
   GO (1)   
Pathway (5)   
   KEGG PATHWAY (2)   
   KEGG MODULE (2)   
   BioSystems (1)   
Disease (2)   
   KEGG DISEASE (2)   
Chemical reaction (10)   
   KEGG ENZYME (10)   
Gene (59)   
   KEGG ORTHOLOGY (59)   
Literature (5)   
   PubMed (5)   
All databases (83)   

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