KEGG PATHWAY: ko03070

PATHWAY: ko03070

Entry

ko03070 Pathway

Name

Bacterial secretion system

Description

Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.

Class

Environmental Information Processing; Membrane transport

Pathway map

ko03070

Bacterial secretion system

Module

M00325	alpha-Hemolysin/cyclolysin transport system [PATH:ko03070]
M00331	Type II general secretion system [PATH:ko03070]
M00332	Type III secretion system [PATH:ko03070]
M00333	Type IV secretion system [PATH:ko03070]
M00334	Type VI secretion system [PATH:ko03070]
M00335	Sec (secretion) system [PATH:ko03070]
M00336	Twin-arginine translocation (Tat) system [PATH:ko03070]

Other DBs

BSID:

447

GO:

0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953

Orthology

K12340	outer membrane channel protein
K11003	hemolysin D
K11004	ATP-binding cassette, subfamily B, bacterial HlyB/CyaB
K03221	type III secretion protein SctF
K04056	type III secretion protein SctO
K04057	type III secretion protein SctP
K04059	type III secretion protein SctX
K03219	type III secretion protein SctC
K04058	type III secretion protein SctW
K03222	type III secretion protein SctJ
K03226	type III secretion protein SctR
K03227	type III secretion protein SctS
K03228	type III secretion protein SctT
K03229	type III secretion protein SctU
K03230	type III secretion protein SctV
K03224	ATP synthase in type III secretion protein SctN [EC:3.6.3.14]
K03225	type III secretion protein SctQ
K03223	type III secretion protein SctL
K02453	general secretion pathway protein D
K02465	general secretion pathway protein S
K02452	general secretion pathway protein C
K02455	general secretion pathway protein F
K02456	general secretion pathway protein G
K02457	general secretion pathway protein H
K02458	general secretion pathway protein I
K02459	general secretion pathway protein J
K02460	general secretion pathway protein K
K02461	general secretion pathway protein L
K02462	general secretion pathway protein M
K02454	general secretion pathway protein E
K02464	general secretion pathway protein O [EC:2.1.1.- 3.4.23.43]
K03072	preprotein translocase subunit SecD
K12257	SecD/SecF fusion protein
K03074	preprotein translocase subunit SecF
K03073	preprotein translocase subunit SecE
K03075	preprotein translocase subunit SecG
K03076	preprotein translocase subunit SecY
K03210	preprotein translocase subunit YajC
K03217	preprotein translocase subunit YidC
K03070	preprotein translocase subunit SecA
K13301	secretion monitor
K03110	fused signal recognition particle receptor
K03071	preprotein translocase subunit SecB
K03106	signal recognition particle subunit SRP54
K03116	sec-independent protein translocase protein TatA
K03117	sec-independent protein translocase protein TatB
K03118	sec-independent protein translocase protein TatC
K03425	sec-independent protein translocase protein TatE
K11028	vacuolating cytotoxin
K11017	hemolysin activation/secretion protein
K11016	hemolysin
K12341	adhesin YadA
K12342	adhesin YadB/C
K03194	type IV secretion system protein VirB1
K03197	type IV secretion system protein VirB2
K03198	type IV secretion system protein VirB3
K03200	type IV secretion system protein VirB5
K03202	type IV secretion system protein VirB7
K03204	type IV secretion system protein VirB9
K03201	type IV secretion system protein VirB6
K03203	type IV secretion system protein VirB8
K03195	type IV secretion system protein VirB10
K03199	type IV secretion system protein VirB4
K03196	type IV secretion system protein VirB11
K03205	type IV secretion system protein VirD4
K11904	type VI secretion system secreted protein VgrG
K11903	type VI secretion system secreted protein Hcp
K11906	type VI secretion system protein VasD
K11891	type VI secretion system protein ImpL
K11892	type VI secretion system protein ImpK
K11907	type VI secretion system protein VasG
K11912	serine/threonine-protein kinase PpkA [EC:2.7.11.1]
K11913	type VI secretion system protein
K11915	serine/threonine protein phosphatase Stp1 [EC:3.1.3.16]

Compound

C00002

ATP

Reference

PMID:11173102

Authors

Kim JF.

Title

Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.

Journal

Trends Genet 17:65-9 (2001)

Reference

PMID:11309112

Authors

Plano GV, Day JB, Ferracci F.

Title

Type III export: new uses for an old pathway.

Journal

Mol Microbiol 40:284-93 (2001)

Reference

PMID:11413015

Authors

Gauthier A, Finlay BB.

Title

Bacterial pathogenesis: the answer to virulence is in the pore.

Journal

Curr Biol 11:R264-7 (2001)

Reference

PMID:10047550

Authors

Burns DL.

Title

Biochemistry of type IV secretion.

Journal

Curr Opin Microbiol 2:25-9 (1999)

Reference

PMID:10920394

Authors

Christie PJ, Vogel JP.

Title

Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.

Journal

Trends Microbiol 8:354-60 (2000)

Reference

PMID:11309113

Authors

Christie PJ.

Title

Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.

Journal

Mol Microbiol 40:294-305 (2001)

Reference

PMID:10481178

Authors

Nunn D.

Title

Bacterial type II protein export and pilus biogenesis: more than just homologies?

Journal

Trends Cell Biol 9:402-8 (1999)

Reference

PMID:11309111

Authors

Sandkvist M.

Title

Biology of type II secretion.

Journal

Mol Microbiol 40:271-83 (2001)

Reference

PMID:11349009

Authors

Sandkvist M.

Title

Type II secretion and pathogenesis.

Journal

Infect Immun 69:3523-35 (2001)

Reference

PMID:15546664

Authors

Delepelaire P

Title

Type I secretion in gram-negative bacteria.

Journal

Biochim Biophys Acta 1694:149-61 (2004)

Reference

PMID:18406342

Authors

Hazes B, Frost L

Title

Towards a systems biology approach to study type II/IV secretion systems.

Journal

Biochim Biophys Acta 1778:1839-50 (2008)

Reference

PMID:16448494

Authors

Johnson TL, Abendroth J, Hol WG, Sandkvist M

Title

Type II secretion: from structure to function.

Journal

FEMS Microbiol Lett 255:175-86 (2006)

Reference

PMID:15546665

Authors

Filloux A

Title

The underlying mechanisms of type II protein secretion.

Journal

Biochim Biophys Acta 1694:163-79 (2004)

Reference

PMID:19396170

Authors

Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC

Title

A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.

Journal

Nat Struct Mol Biol 16:468-76 (2009)

Reference

PMID:15590783

Authors

Ghosh P

Title

Process of protein transport by the type III secretion system.

Journal

Microbiol Mol Biol Rev 68:771-95 (2004)

Reference

PMID:12360191

Authors

Cornelis GR

Title

The Yersinia Ysc-Yop 'type III' weaponry.

Journal

Nat Rev Mol Cell Biol 3:742-52 (2002)

Reference

PMID:17215876

Authors

Baron C

Title

VirB8: a conserved type IV secretion system assembly factor and drug target.

Journal

Biochem Cell Biol 84:890-9 (2006)

Reference

PMID:17943123

Authors

Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S

Title

Helicobacter exploits integrin for type IV secretion and kinase activation.

Journal

Nature 449:862-6 (2007)

Reference

PMID:16092524

Authors

Christie PJ, Cascales E

Title

Structural and dynamic properties of bacterial type IV secretion systems (review).

Journal

Mol Membr Biol 22:51-61 (2005)

Reference

PMID:15546668

Authors

Christie PJ

Title

Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.

Journal

Biochim Biophys Acta 1694:219-34 (2004)

Reference

PMID:15590781

Authors

Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D

Title

Type V protein secretion pathway: the autotransporter story.

Journal

Microbiol Mol Biol Rev 68:692-744 (2004)

Reference

PMID:9778731

Authors

Henderson IR, Navarro-Garcia F, Nataro JP

Title

The great escape: structure and function of the autotransporter proteins.

Journal

Trends Microbiol 6:370-8 (1998)

Reference

PMID:18524912

Authors

Filloux A, Hachani A, Bleves S

Title

The bacterial type VI secretion machine: yet another player for protein transport across membranes.

Journal

Microbiology 154:1570-83 (2008)

Reference

PMID:19251641

Authors

Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ

Title

Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.

Journal

Proc Natl Acad Sci U S A 106:4154-9 (2009)

Reference

PMID:17603507

Authors

Kulasekara HD, Miller SI

Title

Threonine phosphorylation times bacterial secretion.

Journal

Nat Cell Biol 9:734-6 (2007)

Reference

PMID:18078384

Authors

Driessen AJ, Nouwen N

Title

Protein translocation across the bacterial cytoplasmic membrane.

Journal

Annu Rev Biochem 77:643-67 (2008)

Reference

PMID:14641032

Authors

Pool MR

Title

Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?

Journal

Biochem Soc Trans 31:1232-7 (2003)

Reference

PMID:19299134

Authors

Desvaux M, Hebraud M, Talon R, Henderson IR

Title

Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.

Journal

Trends Microbiol 17:139-45 (2009)

Reference

PMID:15063851

Authors

Nakatogawa H, Murakami A, Ito K

Title

Control of SecA and SecM translation by protein secretion.

Journal

Curr Opin Microbiol 7:145-50 (2004)

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Ontology (10)   
   KEGG BRITE (1)   
   GO (9)   
Pathway (10)   
   KEGG PATHWAY (2)   
   KEGG MODULE (7)   
   BioSystems (1)   
Chemical substance (1)   
   KEGG COMPOUND (1)   
Chemical reaction (5)   
   KEGG ENZYME (5)   
Gene (74)   
   KEGG ORTHOLOGY (74)   
Literature (29)   
   PubMed (29)   
All databases (129)   

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