KEGG   PATHWAY: ko03420Help
Entry
ko03420                     Pathway                                
Name
Nucleotide excision repair
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Nucleotide excision repair
ko03420

All organismsOrtholog table
Module
M00262  
DNA polymerase delta complex [PATH:ko03420]
M00288  
RPA complex [PATH:ko03420]
M00289  
RF-C complex [PATH:ko03420]
M00290  
Holo-TFIIH complex [PATH:ko03420]
M00385  
Cul4-DDB1-DDB2 complex [PATH:ko03420]
M00386  
Cul4-DDB1-CSA complex [PATH:ko03420]
Disease
H00403  
Disorders of nucleotide excision repair
H00658  
Syndromic X-linked mental retardation
H00821  
Macular degeneration
Other DBs
BSID: 
GO: 
Orthology
K03723  
transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-]
K03701  
excinuclease ABC subunit A
K03702  
excinuclease ABC subunit B
K03703  
excinuclease ABC subunit C
K03657  
DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]
K02335  
DNA polymerase I [EC:2.7.7.7]
K01971  
DNA ligase (ATP) [EC:6.5.1.1]
K01972  
DNA ligase (NAD+) [EC:6.5.1.2]
K03868  
RING-box protein 1
K10609  
cullin 4
K10610  
DNA damage-binding protein 1
K10140  
DNA damage-binding protein 2
K10838  
xeroderma pigmentosum group C-complementing protein
K10839  
UV excision repair protein RAD23
K10840  
centrin-2
K10570  
DNA excision repair protein ERCC-8
K10841  
DNA excision repair protein ERCC-6
K02202  
cyclin-dependent kinase 7 [EC:2.7.11.23 2.7.11.22]
K10842  
CDK-activating kinase assembly factor MAT1
K06634  
cyclin H
K10843  
DNA excision repair protein ERCC-3 [EC:3.6.4.12]
K10844  
DNA excision repair protein ERCC-2 [EC:3.6.4.12]
K10845  
TFIIH basal transcription factor complex TTD-A subunit
K03141  
transcription initiation factor TFIIH subunit 1
K03142  
transcription initiation factor TFIIH subunit 2
K03143  
transcription initiation factor TFIIH subunit 3
K03144  
transcription initiation factor TFIIH subunit 4
K10846  
DNA excision repair protein ERCC-5
K10847  
DNA-repair protein complementing XP-A cells
K07466  
replication factor A1
K10739  
replication factor A2
K10740  
replication factor A3
K10741  
replication factor A4
K10848  
DNA excision repair protein ERCC-4 [EC:3.1.-.-]
K10849  
DNA excision repair protein ERCC-1
K02327  
DNA polymerase delta subunit 1 [EC:2.7.7.7]
K02328  
DNA polymerase delta subunit 2
K03504  
DNA polymerase delta subunit 3
K03505  
DNA polymerase delta subunit 4
K02324  
DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
K02325  
DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
K02326  
DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
K03506  
DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
K04802  
proliferating cell nuclear antigen
K10754  
replication factor C subunit 1
K10755  
replication factor C subunit 2/4
K10756  
replication factor C subunit 3/5
K10747  
DNA ligase 1 [EC:6.5.1.1]
Reference
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
Reference
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
Reference
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases] Japanese
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders] Japanese
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
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