| Entry |
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| Name |
Homologous recombination
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| Description |
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
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| Class |
Genetic Information Processing; Replication and repair
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| Pathway map |
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| Module |
| DNA polymerase III complex, bacteria [PATH: ko03440] | | | | | | | | BRCA1-associated genome surveillance complex (BASC) [PATH: ko03440] |
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| Disease |
| DNA repair defects | | Defects in RecQ helicases | | Ataxia with ocular apraxia (AOA) | | Congenital mirror movements (CMM) |
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| Other DBs |
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| Orthology |
| single-stranded-DNA-specific exonuclease [EC:3.1.-.-] | | single-strand DNA-binding protein | | DNA replication and repair protein RecF | | DNA repair protein RecO (recombination protein O) | | recombination protein RecR | | recombination protein RecA | | | | holliday junction DNA helicase RuvA [EC: 3.6.4.12] | | holliday junction DNA helicase RuvB [EC: 3.6.4.12] | | crossover junction endodeoxyribonuclease RuvC [EC: 3.1.22.4] | | ATP-dependent DNA helicase RecG [EC: 3.6.4.12] | | exodeoxyribonuclease V beta subunit [EC: 3.1.11.5] | | exodeoxyribonuclease V gamma subunit [EC: 3.1.11.5] | | exodeoxyribonuclease V alpha subunit [EC: 3.1.11.5] | | DNA polymerase III subunit alpha [EC: 2.7.7.7] | | DNA polymerase III subunit alpha, Gram-positive type [EC: 2.7.7.7] | | DNA polymerase III subunit beta [EC: 2.7.7.7] | | DNA polymerase III subunit gamma/tau [EC: 2.7.7.7] | | DNA polymerase III subunit delta [EC: 2.7.7.7] | | DNA polymerase III subunit delta' [EC: 2.7.7.7] | | DNA polymerase III subunit epsilon [EC: 2.7.7.7] | | | | DNA polymerase III subunit theta [EC: 2.7.7.7] | | DNA polymerase III subunit chi [EC: 2.7.7.7] | | DNA polymerase III subunit psi [EC: 2.7.7.7] | | primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:3.6.4.-] | | primosomal replication protein N | | primosomal replication protein N'' | | DNA replication protein DnaT | | DNA repair protein RAD50 [EC:3.6.-.-] | | double-strand break repair protein MRE11 | | DNA repair protein XRS2 | | nijmegen breakage syndrome protein 1 | | DNA repair protein RAD55 | | DNA repair protein RAD57 | | replication factor A1 | | replication factor A2 | | replication factor A3 | | replication factor A4 | | DNA repair protein RAD51 | | DNA repair and recombination protein RAD52 | | breast cancer 2 susceptibility protein | | 26 proteasome complex subunit DSS1 | | RAD51-like protein 1 | | RAD51-like protein 2 | | RAD51-like protein 3 | | DNA-repair protein XRCC2 | | DNA-repair protein XRCC3 | | DNA repair protein RAD59 | | DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-] | | DNA repair and recombination protein RAD54B [EC:3.6.4.-] | | DNA polymerase delta subunit 1 [EC: 2.7.7.7] | | DNA polymerase delta subunit 2 | | DNA polymerase delta subunit 3 | | DNA polymerase delta subunit 4 | | | | | | crossover junction endonuclease MUS81 [EC:3.1.22.-] | | crossover junction endonuclease EME1 [EC:3.1.22.-] |
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| Reference |
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| Authors |
Maloisel L, Fabre F, Gangloff S. |
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| Title |
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension. |
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| Journal |
Mol Cell Biol 28:1373-82 (2008) |
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| Reference |
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| Authors |
Haruta-Takahashi N, Iwasaki H. |
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| Title |
[Recombination mediators] Japanese |
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| Journal |
Seikagaku 79:449-53 (2007) |
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| Reference |
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| Authors |
Ouyang KJ, Woo LL, Ellis NA. |
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| Title |
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases. |
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| Journal |
Mech Ageing Dev 129:425-40 (2008) |
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| Reference |
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| Authors |
Kawabata M, Kawabata T, Nishibori M. |
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| Title |
Role of recA/RAD51 family proteins in mammals. |
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| Journal |
Acta Med Okayama 59:1-9 (2005) |
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| Reference |
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| Authors |
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A. |
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| Title |
Mitotic recombination in Saccharomyces cerevisiae. |
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| Journal |
Curr Genet 42:185-98 (2003) |
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| Reference |
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| Authors |
Heyer WD, Li X, Rolfsmeier M, Zhang XP. |
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| Title |
Rad54: the Swiss Army knife of homologous recombination? |
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| Journal |
Nucleic Acids Res 34:4115-25 (2006) |
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| Reference |
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| Authors |
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R. |
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| Title |
Recombination proteins and rescue of arrested replication forks. |
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| Journal |
DNA Repair (Amst) 6:967-80 (2007) |
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| Reference |
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| Authors |
Hanaoka F. |
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| Title |
[DNA Replication and Repair] (In Japanese) |
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| Journal |
Yodosha (2004) |
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| Reference |
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| Authors |
Ohashi E, Ohmori H. |
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| Title |
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese) |
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| Journal |
Cell Technology 19:1449-53 (2000) |
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