KEGG   PATHWAY: ko04112Help
Entry
ko04112                     Pathway                                

Name
Cell cycle - Caulobacter
Description
Cell cycle progression of Caulobacter crescentus is implemented by an elaborate transcriptional regulatory network. During the life cycle, Caulobacter divides asymmetrically producing two distinct cell types with specialized development programs. The sessile stalked cell immediately initiates a new round of division cycle, whereas the motile swarmer cell remains in the G1 phase for a defined interval before differentiating into the stalked cell and entering into the S phase. The division process is centered around three master regulator proteins, DnaA, GcrA, and CtrA. DnaA and GcrA together drive the synthesis of proteins needed to complete DNA replication. CtrA controls the transcription of a diverse group of genes, which are required for essential morphological, metabolic, and cell cycle events.
Class
Cellular Processes; Cell growth and death
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Pathway map
Cell cycle - Caulobacter
ko04112

All organismsOrtholog table
Module
M00511  
PleC-PleD (cell fate control) two-component regulatory system [PATH:ko04112]
M00512  
CckA-CtrA/CpdR (cell cycle control) two-component regulatory system [PATH:ko04112]
Other DBs
BSID: 
GO: 
Orthology
K02313  
chromosomal replication initiator protein
K02314  
replicative DNA helicase [EC:3.6.4.12]
K13583  
GcrA cell cycle regulator
K13584  
two-component system, cell cycle response regulator CtrA
K13581  
modification methylase [EC:2.1.1.72]
K01338  
ATP-dependent Lon protease [EC:3.4.21.53]
K03531  
cell division protein FtsZ
K03589  
cell division protein FtsQ
K03590  
cell division protein FtsA
K03588  
cell division protein FtsW
K02563  
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]
K13585  
holdfast attachment protein HfaA
K13586  
holdfast attachment protein HfaB
K13582  
localization factor PodJL
K06985  
aspartyl protease family protein
K11749  
regulator of sigma E protease [EC:3.4.24.-]
K07716  
two-component system, cell cycle sensor histidine kinase PleC [EC:2.7.13.3]
K11357  
two-component system, cell cycle sensor histidine kinase DivJ [EC:2.7.13.3]
K11443  
two-component system, cell cycle response regulator DivK
K13587  
two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3]
K13588  
histidine phosphotransferase ChpT
K13589  
two-component system, cell cycle response regulator CpdR
K03544  
ATP-dependent Clp protease ATP-binding subunit ClpX
K01358  
ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
K02488  
two-component system, cell cycle response regulator
K13590  
diguanylate cyclase
K13591  
two-component system, cell cycle response regulator PopA
K13592  
regulator of CtrA degradation
K13245  
c-di-GMP-specific phosphodiesterase [EC:3.1.4.52]
K13593  
cyclic-di-GMP phosphodiesterase, flagellum assembly factor TipF
K02651  
pilus assembly protein Flp/PilA
Compound
C16463  
3',5'-Cyclic diGMP
Reference
  Authors
Shen X, Collier J, Dill D, Shapiro L, Horowitz M, McAdams HH
  Title
Architecture and inherent robustness of a bacterial cell-cycle control system.
  Journal
Proc Natl Acad Sci U S A 105:11340-5 (2008)
Reference
  Authors
Curtis PD, Brun YV
  Title
Getting in the loop: regulation of development in Caulobacter crescentus.
  Journal
Microbiol Mol Biol Rev 74:13-41 (2010)
Reference
  Authors
Skerker JM, Laub MT
  Title
Cell-cycle progression and the generation of asymmetry in Caulobacter crescentus.
  Journal
Nat Rev Microbiol 2:325-37 (2004)
Reference
  Authors
Jenal U, Galperin MY
  Title
Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.
  Journal
Curr Opin Microbiol 12:152-60 (2009)
Reference
  Authors
Thanbichler M
  Title
Spatial regulation in Caulobacter crescentus.
  Journal
Curr Opin Microbiol 12:715-21 (2009)
Reference
  Authors
Jenal U
  Title
The role of proteolysis in the Caulobacter crescentus cell cycle and development.
  Journal
Res Microbiol 160:687-95 (2009)
Reference
  Authors
Hengge R
  Title
Principles of c-di-GMP signalling in bacteria.
  Journal
Nat Rev Microbiol 7:263-73 (2009)
Reference
  Authors
Goley ED, Toro E, McAdams HH, Shapiro L
  Title
Dynamic chromosome organization and protein localization coordinate the regulatory circuitry that drives the bacterial cell cycle.
  Journal
Cold Spring Harb Symp Quant Biol 74:55-64 (2009)
Reference
  Authors
Li S, Brazhnik P, Sobral B, Tyson JJ
  Title
Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus.
  Journal
PLoS Comput Biol 5:e1000463 (2009)

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