KEGG   PATHWAY: ko04145Help
Entry
ko04145                     Pathway                                

Name
Phagosome
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Phagosome
ko04145

All organismsOrtholog table
Module
M00401  
Sec61 complex [PATH:ko04145]
Disease
H00751  
Asphyxiating thoracic dystrophy
H00821  
Macular degeneration
H00838  
Congenital fibrosis of the extraocular muscles (CFEOM)
H00856  
Distal hereditary motor neuropathies (dHMN)
H00957  
Fleck corneal dystrophy (FCD)
H00984  
Bare lymphocyte syndrome (BLS) type1
H01108  
CD36 deficiency
H01109  
Chronic mucocutaneous candidiasis (CMC)
H01240  
Immune thrombocytopenia (ITP)
H01255  
Juvenile-onset dystonia
Other DBs
BSID: 
GO: 
Orthology
K13505  
vesicle-associated membrane protein 3
K13813  
syntaxin 12/13
K08488  
syntaxin 7
K05692  
actin beta/gamma 1
K13882  
coronin-1A
K08492  
syntaxin 18
K08517  
vesicle transport protein SEC22
K06751  
major histocompatibility complex, class I
K06752  
major histocompatibility complex, class II
K07887  
Ras-related protein Rab-5A
K07888  
Ras-related protein Rab-5B
K07889  
Ras-related protein Rab-5C
K12478  
early endosome antigen 1
K00914  
phosphatidylinositol 3-kinase [EC:2.7.1.137]
K06503  
transferrin receptor
K12182  
hepatocyte growth factor-regulated tyrosine kinase substrate
K02145  
V-type H+-transporting ATPase subunit A [EC:3.6.3.14]
K02147  
V-type H+-transporting ATPase subunit B [EC:3.6.3.14]
K02148  
V-type H+-transporting ATPase subunit C [EC:3.6.3.14]
K02149  
V-type H+-transporting ATPase subunit D [EC:3.6.3.14]
K02150  
V-type H+-transporting ATPase subunit E [EC:3.6.3.14]
K02151  
V-type H+-transporting ATPase subunit F [EC:3.6.3.14]
K02152  
V-type H+-transporting ATPase subunit G [EC:3.6.3.14]
K02153  
V-type H+-transporting ATPase subunit H [EC:3.6.3.14]
K02154  
V-type H+-transporting ATPase subunit I [EC:3.6.3.14]
K02146  
V-type H+-transporting ATPase subunit AC39 [EC:3.6.3.14]
K02144  
V-type H+-transporting ATPase 54 kD subunit [EC:3.6.3.14]
K02155  
V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14]
K03661  
V-type H+-transporting ATPase 21kDa proteolipid subunit [EC:3.6.3.14]
K03662  
V-type H+-transporting ATPase S1 subunit [EC:3.6.3.14]
K07897  
Ras-related protein Rab-7A
K07898  
Ras-related protein Rab-7B
K13883  
Rab-interacting lysosomal protein
K10413  
dynein heavy chain 1, cytosolic
K10414  
dynein heavy chain 2, cytosolic
K10415  
dynein intermediate chain, cytosolic
K10416  
dynein light intermediate chain 1, cytosolic
K07374  
tubulin alpha
K07375  
tubulin beta
K06528  
lysosomal-associated membrane protein 1/2
K00921  
1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
K10089  
cation-dependent mannose-6-phosphate receptor
K13240  
nitric-oxide synthase, brain [EC:1.14.13.39]
K10789  
myeloperoxidase [EC:1.11.2.2]
K01365  
cathepsin L [EC:3.4.22.15]
K01368  
cathepsin S [EC:3.4.22.27]
K10956  
protein transport protein SEC61 subunit alpha
K09481  
protein transport protein SEC61 subunit beta
K07342  
protein transport protein SEC61 subunit gamma and related proteins
K05653  
ATP-binding cassette, subfamily B (MDR/TAP), member 2
K05654  
ATP-binding cassette, subfamily B (MDR/TAP), member 3
K08057  
calreticulin
K08054  
calnexin
K06513  
CD89 antigen
K06498  
high affinity immunoglobulin gamma Fc receptor I
K06472  
low affinity immunoglobulin gamma Fc region receptor II-a
K12560  
low affinity immunoglobulin gamma Fc region receptor II-b
K16824  
low affinity immunoglobulin gamma Fc region receptor II-c
K06463  
low affinity immunoglobulin gamma Fc region receptor III
K06856  
immunoglobulin heavy chain
K01330  
complement component 1, r subcomponent [EC:3.4.21.41]
K06461  
integrin alpha M
K06464  
integrin beta 2
K03990  
complement component 3
K10066  
collectin sub-family member 11
K10062  
collectin sub-family member 12
K03991  
mannose-binding lectin
K10067  
surfactant, pulmonary-associated protein A
K10068  
surfactant, pulmonary-associated protein D
K06487  
integrin alpha V
K06481  
integrin alpha 2
K06484  
integrin alpha 5
K05719  
integrin beta 1
K06493  
integrin beta 3
K06588  
integrin beta 5
K16857  
thrombospondin 1
K04659  
thrombospondin 2/3/4/5
K10159  
toll-like receptor 2
K10169  
toll-like receptor 6
K10160  
toll-like receptor 4
K04391  
CD14 antigen
K06560  
mannose receptor, C type
K06563  
CD209 antigen
K10074  
C-type lectin domain family 7, member A
K06558  
macrophage scavenger receptor 1
K13884  
macrophage receptor with collagenous structure
K08763  
oxidised low-density lipoprotein receptor 1
K13885  
scavenger receptor class B, member 1
K06259  
CD36 antigen
K08009  
cytochrome b-245, alpha polypeptide
K08008  
NADPH oxidase
K04392  
Ras-related C3 botulinum toxin substrate 1
K08011  
neutrophil cytosolic factor 1
K08010  
neutrophil cytosolic factor 2
K08012  
neutrophil cytosolic factor 4
Compound
C00007  
Oxygen
C00027  
Hydrogen peroxide
C00533  
Nitric oxide
C00704  
O2.-
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)

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