KEGG   PATHWAY: ko04360Help
Entry
ko04360                     Pathway                                

Name
Axon guidance
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development
BRITE hierarchy
Pathway map
Axon guidance
ko04360

All organismsOrtholog table
Disease
H00577  
Syndromic X-linked mental retardation with epilepsy or seizures
H00698  
Nemaline myopathy
H00764  
Cri du chat syndrome
H01034  
L1 syndrome
H01202  
Cataract
H01287  
Congenital mirror movements (CMM)
Other DBs
BSID: 
GO: 
Orthology
K06843  
netrin 1
K06765  
deleted in colorectal carcinoma
K04392  
Ras-related C3 botulinum toxin substrate 1
K07860  
Ras-related C3 botulinum toxin substrate 2
K07861  
Ras-related C3 botulinum toxin substrate 3
K07520  
actin-binding LIM protein
K04348  
serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
K06268  
serine/threonine-protein phosphatase 2B regulatory subunit
K17332  
nuclear factor of activated T-cells, cytoplasmic 2
K17333  
nuclear factor of activated T-cells, cytoplasmic 3
K17334  
nuclear factor of activated T-cells, cytoplasmic 4
K04513  
Ras homolog gene family, member A
K04514  
Rho-associated protein kinase 1 [EC:2.7.11.1]
K17388  
Rho-associated protein kinase 2 [EC:2.7.11.1]
K07521  
netrin receptor unc-5
K06844  
netrin 3
K06845  
netrin 4
K07522  
netrin-G1
K16359  
netrin-G2
K07523  
netrin-G1 ligand
K16351  
netrin-G2 ligand
K05462  
ephrin-A
K05703  
tyrosine-protein kinase Fyn [EC:2.7.10.2]
K05463  
ephrin-B
K05725  
focal adhesion kinase 1 [EC:2.7.10.2]
K07524  
regulator of G-protein signalling 3
K05102  
Eph receptor A1 [EC:2.7.10.1]
K05103  
Eph receptor A2 [EC:2.7.10.1]
K05104  
Eph receptor A3 [EC:2.7.10.1]
K05105  
Eph receptor A4 [EC:2.7.10.1]
K05106  
Eph receptor A5 [EC:2.7.10.1]
K05107  
Eph receptor A6 [EC:2.7.10.1]
K05108  
EphA7 [EC:2.7.10.1]
K05109  
Eph receptor A8 [EC:2.7.10.1]
K05110  
Eph receptor B1 [EC:2.7.10.1]
K05111  
Eph receptor B2 [EC:2.7.10.1]
K05112  
Eph receptor B3 [EC:2.7.10.1]
K05113  
Eph receptor B4 [EC:2.7.10.1]
K05114  
Eph receptor B6 [EC:2.7.10.1]
K06619  
abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K07525  
neuronal guanine nucleotide exchange factor
K04393  
cell division control protein 42
K04409  
p21-activated kinase 1 [EC:2.7.11.1]
K04410  
p21-activated kinase 2 [EC:2.7.11.1]
K05733  
p21-activated kinase 3 [EC:2.7.11.1]
K05734  
p21-activated kinase 4 [EC:2.7.11.1]
K05735  
p21-activated kinase 6 [EC:2.7.11.1]
K05736  
p21-activated kinase 7 [EC:2.7.11.1]
K04352  
Ras GTPase-activating protein 1
K02833  
GTPase HRas
K07827  
GTPase KRas
K07828  
GTPase NRas
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04189  
C-X-C chemokine receptor type 4
K04630  
guanine nucleotide-binding protein G(i) subunit alpha
K06838  
slit 1
K06839  
slit 2
K06850  
slit 3
K06753  
roundabout, axon guidance receptor 1
K06754  
roundabout, axon guidance receptor 2
K06755  
roundabout, axon guidance receptor 3
K07526  
SLIT-ROBO Rho GTPase activating protein
K06840  
semaphorin 3
K06820  
plexin A
K06724  
neuropilin 1
K06550  
L1 cell adhesion molecule
K03083  
glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02090  
cyclin-dependent kinase 5 [EC:2.7.11.22]
K07527  
tyrosine-protein kinase Fes/Fps [EC:2.7.10.2]
K07528  
dihydropyrimidinase-like 2
K07529  
dihydropyrimidinase-like 5
K05743  
LIM domain kinase 1 [EC:2.7.11.1]
K05744  
LIM domain kinase 2 [EC:2.7.11.1]
K05765  
cofilin
K07530  
Ras homolog gene family, member D
K07531  
Rho family GTPase 1
K06521  
semaphorin 4
K06841  
semaphorin 5
K06842  
semaphorin 6
K06821  
plexin B
K05099  
proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K07532  
Rho guanine nucleotide exchange factor 12
K06529  
semaphorin 7
K05719  
integrin beta 1
K06572  
plexin C
Compound
C00076  
Calcium cation
Reference
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
Reference
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
Reference
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
Reference
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
Reference
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
Reference
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
Reference
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
Reference
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
Reference
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
Reference
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)

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