KEGG   PATHWAY: ko04640Help
Entry
ko04640                     Pathway                                

Name
Hematopoietic cell lineage
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Hematopoietic cell lineage
ko04640

All organismsOrtholog table
Disease
H00219  
Hemophilia
H00224  
Bernard-Soulier syndrome
Orthology
K05461  
KIT ligand
K05431  
interleukin 7
K05430  
interleukin 4
K05427  
granulocyte-macrophage colony-stimulating factor
K05454  
fms-related tyrosine kinase 3 ligand
K05428  
interleukin 5
K05423  
granulocyte colony-stimulating factor
K04736  
interleukin 3
K05405  
interleukin 6
K05417  
interleukin 11
K04383  
interleukin 1 alpha
K04519  
interleukin 1 beta
K03156  
tumor necrosis factor superfamily, member 2
K05453  
macrophage colony-stimulating factor 1
K05437  
erythropoietin
K00431  
thyroid peroxidase [EC:1.11.1.8]
K06854  
thrombopoietin
K06474  
CD34 antigen
K05092  
fms-related tyrosine kinase 3 [EC:2.7.10.1]
K00977  
DNA nucleotidylexotransferase [EC:2.7.7.31]
K06256  
CD44 antigen
K05091  
proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05068  
interleukin 2 receptor alpha
K05072  
interleukin 7 receptor
K06503  
transferrin receptor
K06457  
CD7 antigen
K06449  
CD2 antigen
K06455  
CD5 antigen
K06448  
CD1 antigen
K06454  
CD4 antigen
K06458  
CD8A antigen, alpha polypeptide
K06459  
CD8B antigen, beta polypeptide
K06450  
T-cell surface glycoprotein CD3 delta chain
K06451  
T-cell surface glycoprotein CD3 epsilon chain
K06452  
T-cell surface glycoprotein CD3 gamma chain
K01389  
neprilysin [EC:3.4.24.11]
K06460  
CD9 antigen
K06465  
CD19 antigen
K06467  
CD22 antigen
K06469  
CD24 antigen
K06466  
membrane-spanning 4-domains, subfamily A, member 1
K04012  
complement receptor type 2
K06475  
CD37 antigen
K06856  
immunoglobulin heavy chain
K06468  
Fc receptor, IgE, low affinity II
K04011  
complement component (3b/4b) receptor 1
K05066  
granulocyte-macrophage colony-stimulating factor receptor alpha
K04737  
interleukin 3 receptor alpha
K06473  
CD33 antigen
K05071  
interleukin 4 receptor
K05055  
interleukin 6 receptor
K06498  
high affinity immunoglobulin gamma Fc receptor I
K05090  
macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K11140  
aminopeptidase N [EC:3.4.11.2]
K06461  
integrin alpha M
K04391  
CD14 antigen
K05073  
interleukin 9 receptor
K04386  
interleukin 1 receptor type I
K04387  
interleukin 1 receptor type II
K05061  
granulocyte colony-stimulating factor receptor
K05067  
interleukin 5 receptor alpha
K05079  
erythropoietin receptor
K06259  
CD36 antigen
K04006  
decay accelerating factor
K04008  
CD59 antigen
K05056  
interleukin 11 receptor alpha
K06493  
integrin beta 3
K06476  
integrin alpha 2B
K06263  
platelet glycoprotein IX
K06261  
platelet glycoprotein Ib alpha chain
K06262  
platelet glycoprotein Ib beta chain
K06260  
platelet glycoprotein V
K06480  
integrin alpha 1
K06481  
integrin alpha 2
K06482  
integrin alpha 3
K06483  
integrin alpha 4
K06484  
integrin alpha 5
K06485  
integrin alpha 6
Compound
G01078  
Lewis x-sulfated
G01493  
Lewis x-sulfated
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
(Japanese)
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
Reference
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
Reference
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
Reference
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
Reference
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
Reference
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
Reference
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
Reference
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
Reference
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)

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