KEGG   PATHWAY: ko04728Help
Entry
ko04728                     Pathway                                

Name
Dopaminergic synapse
Description
Dopamine (DA) is  an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Dopaminergic synapse
ko04728

All organismsOrtholog table
Disease
H00548  
Brunner syndrome
H00577  
Syndromic X-linked mental retardation with epilepsy or seizures
H00749  
Episodic ataxias
H00775  
Familial or sporadic hemiplegic migraine
H00783  
Febrile seizures
H00831  
Primary dystonia
H01161  
Aromatic L-amino acid decarboxylase (AADC) deficiency
Other DBs
BSID: 
GO: 
Orthology
K00501  
tyrosine 3-monooxygenase [EC:1.14.16.2]
K01593  
aromatic-L-amino-acid decarboxylase [EC:4.1.1.28]
K08155  
MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
K04144  
dopamine receptor D1
K05840  
dopamine receptor D5
K15493  
neuron-specific vesicular protein calcyon
K04634  
guanine nucleotide-binding protein G(q) subunit alpha
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K04958  
inositol 1,4,5-triphosphate receptor type 1
K04959  
inositol 1,4,5-triphosphate receptor type 2
K04960  
inositol 1,4,5-triphosphate receptor type 3
K02183  
calmodulin
K04515  
calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04348  
serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
K02677  
classical protein kinase C [EC:2.7.11.13]
K04379  
proto-oncogene protein c-fos
K04632  
guanine nucleotide-binding protein G(s) subunit alpha
K04633  
guanine nucleotide-binding protein G(olf) subunit alpha
K08045  
adenylate cyclase 5 [EC:4.6.1.1]
K04345  
protein kinase A [EC:2.7.11.11]
K05870  
cyclic AMP-responsive element-binding protein 1
K04450  
cyclic AMP-dependent transcription factor ATF-2
K04374  
cyclic AMP-dependent transcription factor ATF-4
K09048  
cyclic AMP-responsive element-binding protein 3
K09047  
cyclic AMP-responsive element-binding protein 5
K09049  
cyclic AMP-dependent transcription factor ATF-6 beta
K04441  
p38 MAP kinase [EC:2.7.11.24]
K04440  
c-Jun N-terminal kinase [EC:2.7.11.24]
K15494  
protein phosphatase 1 regulatory subunit 1B
K06269  
serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
K04833  
voltage-gated sodium channel type I alpha
K04850  
voltage-dependent calcium channel L type alpha-1C
K04851  
voltage-dependent calcium channel L type alpha-1D
K04344  
voltage-dependent calcium channel P/Q type alpha-1A
K04849  
voltage-dependent calcium channel N type alpha-1B
K04997  
potassium inwardly-rectifying channel subfamily J member 3
K05000  
potassium inwardly-rectifying channel subfamily J member 6
K05002  
potassium inwardly-rectifying channel subfamily J member 9
K04999  
potassium inwardly-rectifying channel subfamily J member 5
K04146  
dopamine receptor D3
K04147  
dopamine receptor D4
K04630  
guanine nucleotide-binding protein G(i) subunit alpha
K04534  
guanine nucleotide-binding protein G(o) subunit alpha
K04536  
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
K04537  
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
K07825  
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
K04538  
guanine nucleotide-binding protein subunit beta-4
K04539  
guanine nucleotide-binding protein subunit beta-5
K07826  
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
K04540  
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
K04541  
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
K04542  
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
K04543  
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
K04544  
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
K04545  
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
K04546  
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
K04347  
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04547  
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
K04548  
guanine nucleotide-binding protein G(T) subunit gamma-T1
K04549  
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
K04145  
dopamine receptor D2
K04382  
serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K03456  
serine/threonine-protein phosphatase 2A regulatory subunit A
K04354  
serine/threonine-protein phosphatase 2A regulatory subunit B
K11583  
serine/threonine-protein phosphatase 2A regulatory subunit B''
K11584  
serine/threonine-protein phosphatase 2A regulatory subunit B'
K04456  
RAC serine/threonine-protein kinase [EC:2.7.11.1]
K08822  
glycogen synthase kinase 3 alpha [EC:2.7.11.26]
K03083  
glycogen synthase kinase 3 beta [EC:2.7.11.26]
K05209  
glutamate receptor ionotropic, NMDA 2A
K05210  
glutamate receptor ionotropic, NMDA 2B
K05197  
glutamate receptor 1
K05198  
glutamate receptor 2
K05199  
glutamate receptor 3
K05200  
glutamate receptor 4
K10396  
kinesin family member 5
K02223  
circadian locomoter output cycles kaput protein [EC:2.3.1.48]
K02296  
aryl hydrocarbon receptor nuclear translocator-like protein 1
K05036  
solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
K00274  
monoamine oxidase [EC:1.4.3.4]
K00545  
catechol O-methyltransferase [EC:2.1.1.6]
Compound
C00076  
Calcium cation
C00082  
L-Tyrosine
C00165  
Diacylglycerol
C00238  
Potassium cation
C00355  
3,4-Dihydroxy-L-phenylalanine
C00575  
3',5'-Cyclic AMP
C01161  
3,4-Dihydroxyphenylacetate
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C01330  
Sodium cation
C03758  
Dopamine
C05582  
Homovanillate
C05587  
3-Methoxytyramine
Reference
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
Reference
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
Reference
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
Reference
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
Reference
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
Reference
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium  currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
Reference
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
Reference
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
Reference
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
Reference
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
Reference
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
Reference
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
Reference
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
Reference
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)

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