KEGG   PATHWAY: ko05152Help
Entry
ko05152                     Pathway                                

Name
Tuberculosis
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Tuberculosis
ko05152

All organismsOrtholog table
Disease
H00342  
Tuberculosis
Orthology
K03156  
tumor necrosis factor superfamily, member 2
K03158  
tumor necrosis factor receptor superfamily member 1A
K03171  
tumor necrosis factor receptor type 1-associated DEATH domain protein
K02373  
FAS-associated death domain protein
K04398  
caspase 8 [EC:3.4.22.61]
K04400  
caspase 10 [EC:3.4.22.63]
K02187  
caspase 3 [EC:3.4.22.56]
K04726  
BH3 interacting domain death agonist
K02159  
apoptosis regulator BAX
K08738  
cytochrome c
K04399  
caspase 9 [EC:3.4.22.62]
K02084  
apoptotic protease-activating factor
K04456  
RAC serine/threonine-protein kinase [EC:2.7.11.1]
K02158  
BCL2-antagonist of cell death
K02161  
apoptosis regulator BCL-2
K04515  
calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04687  
interferon gamma
K05132  
interferon gamma receptor 1
K05133  
interferon gamma receptor 2
K11217  
Janus kinase 1 [EC:2.7.10.2]
K04447  
Janus kinase 2 [EC:2.7.10.2]
K11220  
signal transducer and activator of transcription 1
K08060  
class II, major histocompatibility complex, transactivator
K08061  
regulatory factor X 5
K08062  
regulatory factor X-associated ankyrin-containing protein
K08063  
regulatory factor X-associated protein
K08064  
nuclear transcription factor Y, alpha
K08065  
nuclear transcription Y subunit beta
K08066  
nuclear transcription factor Y, gamma
K05870  
cyclic AMP-responsive element-binding protein 1
K06752  
major histocompatibility complex, class II
K06505  
CD74 antigen
K04498  
E1A/CREB-binding protein [EC:2.3.1.48]
K05443  
interleukin 10
K05134  
interleukin 10 receptor alpha
K05135  
interleukin 10 receptor beta
K01368  
cathepsin S [EC:3.4.22.27]
K10059  
C-type lectin domain family 4, member E
K07983  
Fc receptor, IgE, high affinity I, gamma polypeptide
K10074  
C-type lectin domain family 7, member A
K05704  
tyrosine-protein kinase Src [EC:2.7.10.2]
K05855  
spleen tyrosine kinase [EC:2.7.10.2]
K12794  
caspase recruitment domain-containing protein 9
K07369  
mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
K07368  
B-cell CLL/lymphoma 10
K14952  
UDP-MurNAc hydroxylase
K10165  
nucleotide-binding oligomerization domain-containing protein 2
K08846  
receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
K14953  
ipoprotein LpqH
K14954  
lipoprotein LprG
K14955  
lipoprotein LprA
K02040  
phosphate transport system substrate-binding protein
K04043  
molecular chaperone DnaK
K04077  
chaperonin GroEL
K14956  
6 kDa early secretory antigenic target
K05399  
lipopolysaccharide-binding protein
K10159  
toll-like receptor 2
K05398  
toll-like receptor 1
K10169  
toll-like receptor 6
K10160  
toll-like receptor 4
K04391  
CD14 antigen
K05403  
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
K04729  
myeloid differentiation primary response protein MyD88
K04733  
interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
K04730  
interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
K04731  
interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]
K03175  
TNF receptor-associated factor 6
K02580  
nuclear factor NF-kappa-B p105 subunit
K04735  
transcription factor p65
K04441  
p38 MAP kinase [EC:2.7.11.24]
K04371  
extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K04440  
c-Jun N-terminal kinase [EC:2.7.11.24]
K13241  
nitric-oxide synthase, inducible [EC:1.14.13.39]
K05405  
interleukin 6
K05406  
interleukin 12A
K05425  
interleukin 12B
K05482  
interleukin 18
K05426  
interleukin 23, alpha subunit p19
K04383  
interleukin 1 alpha
K04519  
interleukin 1 beta
K10048  
CCAAT/enhancer binding protein (C/EBP), beta
K10049  
CCAAT/enhancer binding protein (C/EBP), gamma
K10161  
toll-like receptor 9
K05414  
interferon alpha
K05415  
interferon beta
K06563  
CD209 antigen
K07532  
Rho guanine nucleotide exchange factor 12
K04513  
Ras homolog gene family, member A
K14957  
lymphocyte-specific protein 1
K08862  
polo-like kinase 3 [EC:2.7.11.21]
K14958  
kinase suppressor of Ras 1
K04366  
RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K13375  
transforming growth factor beta-1
K13376  
transforming growth factor beta-2
K13377  
transforming growth factor beta-3
K07438  
cytochrome P450, family 27, subfamily B (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.13.13]
K08539  
vitamin D3 receptor
K13916  
cathelicidin antimicrobial peptide
K03990  
complement component 3
K04011  
complement component (3b/4b) receptor 1
K06462  
integrin alpha X
K06464  
integrin beta 2
K06461  
integrin alpha M
K06560  
mannose receptor, C type
K04718  
sphingosine kinase [EC:2.7.1.91]
K02183  
calmodulin
K00914  
phosphatidylinositol 3-kinase [EC:2.7.1.137]
K07887  
Ras-related protein Rab-5A
K07888  
Ras-related protein Rab-5B
K07889  
Ras-related protein Rab-5C
K12478  
early endosome antigen 1
K07897  
Ras-related protein Rab-7A
K01379  
cathepsin D [EC:3.4.23.5]
K02154  
V-type H+-transporting ATPase subunit I [EC:3.6.3.14]
K02146  
V-type H+-transporting ATPase subunit AC39 [EC:3.6.3.14]
K02144  
V-type H+-transporting ATPase 54 kD subunit [EC:3.6.3.14]
K03662  
V-type H+-transporting ATPase S1 subunit [EC:3.6.3.14]
K02155  
V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14]
K03661  
V-type H+-transporting ATPase 21kDa proteolipid subunit [EC:3.6.3.14]
K06528  
lysosomal-associated membrane protein 1/2
K01078  
acid phosphatase [EC:3.1.3.2]
K04348  
protein phosphatase 3, catalytic subunit [EC:3.1.3.16]
K06268  
protein phosphatase 3, regulatory subunit
K13882  
coronin-1A
K14949  
serine/threonine-protein kinase PknG [EC:2.7.11.1]
K06856  
immunoglobulin heavy chain
K06498  
high affinity immunoglobulin gamma Fc receptor I
K06472  
low affinity immunoglobulin gamma Fc region receptor II-a
K12560  
low affinity immunoglobulin gamma Fc region receptor II-b
K16824  
low affinity immunoglobulin gamma Fc region receptor II-c
K06463  
low affinity immunoglobulin gamma Fc region receptor III
Compound
C00076  
Calcium cation
C00338  
Lipopolysaccharide
C01194  
1-Phosphatidyl-D-myo-inositol
C01561  
Calcidiol
C01673  
Calcitriol
C04465  
alpha,alpha'-Trehalose 6,6'-bismycolate
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  
Sphingosine 1-phosphate
C19190  
Trehalose-6,6'-dibehenate
Reference
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
Reference
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
Reference
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
Reference
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
Reference
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
Reference
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
Reference
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
Reference
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
Reference
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
Reference
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
Reference
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
Reference
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
Reference
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
Reference
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
Reference
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
Reference
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)

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