| Entry |
|
| Name |
Pathways in cancer
|
| Class |
Human Diseases; Cancers
 |
| Pathway map |

  |
| Disease |
| von Hippel-Lindau syndrome | | Odontoonychodermal dysplasia | | Oligodontia-colorectal cancer syndrome | | Li-Fraumeni syndrome | | Basal cell nevus syndrome | | Pilomatricoma | | Choroid plexus papilloma | | Juvenile polyposis syndrome | | Familial adenomatous polyposis |
|
| Orthology |
| deleted in colorectal carcinoma | | | | | | DCC-interacting protein 13 alpha | | cadherin 1, type 1, E-cadherin | | catenin beta 1 | | catenin alpha | | axin 1 | | axin 2 | | adenomatosis polyposis coli protein | | glycogen synthase kinase 3 beta [EC: 2.7.11.26] | | transcription factor 7 | | transcription factor 7-like 1 | | transcription factor 7-like 2 | | lymphoid enhancer-binding factor 1 | | baculoviral IAP repeat-containing protein 5 | | Myc proto-oncogene protein | | cyclin D1 | | wingless-type MMTV integration site family, member 1 | | wingless-type MMTV integration site family, member 2 | | wingless-type MMTV integration site family, member 3 | | wingless-type MMTV integration site family, member 4 | | wingless-type MMTV integration site family, member 5 | | wingless-type MMTV integration site family, member 6 | | wingless-type MMTV integration site family, member 7 | | wingless-type MMTV integration site family, member 8 | | wingless-type MMTV integration site family, member 9 | | wingless-type MMTV integration site family, member 10 | | wingless-type MMTV integration site family, member 11 | | wingless-type MMTV integration site family, member 16 | | frizzled 1/7 | | frizzled 2 | | frizzled 3 | | frizzled 4 | | frizzled 5/8 | | frizzled 6 | | frizzled 9/10 | | segment polarity protein dishevelled | | collagen, type IV, alpha | | laminin, alpha 1/2 | | laminin, alpha 3/5 | | laminin, alpha 4 | | laminin, beta 1 | | laminin, beta 2 | | laminin, beta 3 | | laminin, beta 4 | | laminin, gamma 1 | | laminin, gamma 2 | | laminin, gamma 3 | | fibronectin 1 | | integrin alpha 2 | | integrin alpha 2B | | integrin alpha 3 | | integrin alpha 6 | | integrin alpha V | | integrin beta 1 | | | | phosphatidylinositol-4,5-bisphosphate 3-kinase [EC: 2.7.1.153] | | phosphoinositide-3-kinase, regulatory subunit | | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC: 3.1.3.67 3.1.3.48 3.1.3.16] | | homeobox protein Nkx-3.1 | | RAC serine/threonine-protein kinase [EC: 2.7.11.1] | | inhibitor of nuclear factor kappa-B kinase subunit alpha [EC: 2.7.11.10] | | inhibitor of nuclear factor kappa-B kinase subunit beta [EC: 2.7.11.10] | | inhibitor of nuclear factor kappa-B kinase subunit gamma | | NF-kappa-B inhibitor alpha | | nuclear factor NF-kappa-B p105 subunit | | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 | | transcription factor p65 | | prostaglandin-endoperoxide synthase 2 [EC: 1.14.99.1] | | | | apoptosis regulator BCL-2 | | baculoviral IAP repeat-containing protein 2/3 | | E3 ubiquitin-protein ligase XIAP | | baculoviral IAP repeat-containing protein 7/8 | | BCL2-like 1 (apoptosis regulator Bcl-X) | | TNF receptor-associated factor 1 | | TNF receptor-associated factor 2 | | TNF receptor-associated factor 3 | | TNF receptor-associated factor 4 | | TNF receptor-associated factor 5 | | TNF receptor-associated factor 6 | | FKBP12-rapamycin complex-associated protein | | BCL2-antagonist of cell death | | forkhead box protein O1 | | E3 ubiquitin-protein ligase Mdm2 [EC: 6.3.2.19] | | tumor protein p53 | | cyclin-dependent kinase inhibitor 1B | | cyclin-dependent kinase inhibitor 1A | | breakpoint cluster region protein [EC: 2.7.11.1] | | abelson tyrosine-protein kinase 1 [EC: 2.7.10.2] | | proto-oncogene C-crk | | E3 ubiquitin-protein ligase CBL [EC: 6.3.2.19] | | signal transducer and activator of transcription 5A | | signal transducer and activator of transcription 5B | | | | signal transducer and activator of transcription 3 | | signal transducer and activator of transcription 1 | | vascular endothelial growth factor A | | vascular endothelial growth factor B | | placenta growth factor | | vascular endothelial growth factor C/D | | transforming growth factor, alpha | | epidermal growth factor | | epidermal growth factor receptor [EC: 2.7.10.1] | | receptor tyrosine-protein kinase erbB-2 [EC: 2.7.10.1] | | platelet derived growth factor A/B | | platelet-derived growth factor receptor alpha [EC: 2.7.10.1] | | platelet-derived growth factor receptor beta [EC: 2.7.10.1] | | insulin-like growth factor 1 | | insulin-like growth factor 1 receptor [EC: 2.7.10.1] | | KIT ligand | | proto-oncogene tyrosine-protein kinase Kit [EC: 2.7.10.1] | | fms-related tyrosine kinase 3 ligand | | fms-related tyrosine kinase 3 [EC: 2.7.10.1] | | hepatocyte growth factor | | proto-oncogene tyrosine-protein kinase Met [EC: 2.7.10.1] | | fibroblast growth factor | | fibroblast growth factor receptor 1 [EC: 2.7.10.1] | | fibroblast growth factor receptor 2 [EC: 2.7.10.1] | | fibroblast growth factor receptor 3 [EC: 2.7.10.1] | | growth factor receptor-binding protein 2 | | son of sevenless | | GTPase HRas | | GTPase KRas | | GTPase NRas | | A-Raf proto-oncogene serine/threonine-protein kinase [EC: 2.7.11.1] | | B-Raf proto-oncogene serine/threonine-protein kinase [EC: 2.7.11.1] | | RAF proto-oncogene serine/threonine-protein kinase [EC: 2.7.11.1] | | mitogen-activated protein kinase kinase 1 [EC: 2.7.12.2] | | mitogen-activated protein kinase kinase 2 [EC: 2.7.12.2] | | extracellular signal-regulated kinase 1/2 [EC: 2.7.11.24] | | transcription factor AP-1 | | proto-oncogene protein c-fos | | matrix metalloproteinase-1 (interstitial collagenase) [EC: 3.4.24.7] | | matrix metalloproteinase-2 (gelatinase A) [EC: 3.4.24.24] | | matrix metalloproteinase-9 (gelatinase B) [EC: 3.4.24.35] | | interleukin 8 | | | | proto-oncogene tyrosine-protein kinase Ret [EC: 2.7.10.1] | | coiled-coil domain-containing protein 6 | | nuclear receptor coactivator 4 | | neurotrophic tyrosine kinase receptor type 1 [EC: 2.7.10.1] | | tropomyosin 3 | | nucleoprotein TPR | | protein TFG | | Ras association domain-containing protein 1 | | Ras association domain-containing protein 5 | | serine/threonine kinase 4 | | death-associated protein kinase [EC: 2.7.11.1] | | phosphatidylinositol phospholipase C, gamma-1 [EC: 3.1.4.11] | | phosphatidylinositol phospholipase C, gamma-2 [EC: 3.1.4.11] | | | | ral guanine nucleotide dissociation stimulator | | Ras-related protein Ral-A | | Ras-related protein Ral-B | | RalA-binding protein 1 | | cell division control protein 42 | | Ras-related C3 botulinum toxin substrate 1 | | Ras-related C3 botulinum toxin substrate 2 | | Ras-related C3 botulinum toxin substrate 3 | | Ras homolog gene family, member A | | | | paired box protein 8 | | peroxisome proliferator-activated receptor gamma | | retinoid X receptor alpha | | retinoid X receptor beta | | retinoid X receptor gamma | | retinoic acid receptor beta | | peroxisome proliferator-activated receptor delta | | junction plakoglobin | | zinc finger and BTB domain-containing protein 16 | | probable transcription factor PML | | retinoic acid receptor alpha | | runt-related transcription factor 1 | | runt-related transcription factor 1; translocated to, 1 | | transcription factor PU.1 | | CCAAT/enhancer binding protein (C/EBP), alpha | | granulocyte-macrophage colony-stimulating factor receptor alpha | | granulocyte colony-stimulating factor receptor | | macrophage colony-stimulating factor 1 receptor [EC: 2.7.10.1] | | interleukin 6 | | cyclin-dependent kinase inhibitor 2A | | E2F transcription factor 1/3 | | E2F transcription factor 2 | | Max protein | | E3 SUMO-protein ligase PIAS2 [EC:6.3.2.-] | | cyclin-dependent kinase inhibitor 2B | | | | cyclin-dependent kinase regulatory subunit CKS1 | | F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2) | | | | cyclin E | | retinoblastoma-associated protein | | microphthalmia-associated transcription factor | | transforming growth factor beta-1 | | transforming growth factor beta-2 | | transforming growth factor beta-3 | | | | | | mothers against decapentaplegic homolog 2/3 | | mothers against decapentaplegic homolog 4 | | ecotropic virus integration site 1 protein | | C-terminal binding protein | | | | DNA mismatch repair protein MLH1 | | DNA mismatch repair protein MSH2 | | DNA mismatch repair protein MSH3 | | DNA mismatch repair protein MSH6 | | apoptosis regulator BAX | | breast cancer 2 susceptibility protein | | DNA repair protein RAD51 | | tumor necrosis factor ligand superfamily member 6 | | tumor necrosis factor receptor superfamily member 6 | | FAS-associated death domain protein | | | | BH3 interacting domain death agonist | | cytochrome c | | von Hippel-Lindau disease tumor supressor | | transcription elongation factor B, polypeptide 1 | | transcription elongation factor B, polypeptide 2 | | RING-box protein 1 | | cullin 2 | | hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.-] | | fumarate hydratase, class II [EC: 4.2.1.2] | | hypoxia-inducible factor 1 alpha | | hypoxia-inducible factor 2 alpha | | aryl hydrocarbon receptor nuclear translocator | | aryl hydrocarbon receptor nuclear translocator 2 | | | | MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 | | sonic hedgehog | | patched 1 | | smoothened | | costal 2 | | | | suppressor of fused | | zinc finger protein GLI1 | | zinc finger protein GLI2 | | zinc finger protein GLI3 | | bone morphogenetic protein 2/4 | | hedgehog interacting protein | | patched 2 | | androgen receptor | | molecular chaperone HtpG | | heat shock protein 90kDa beta | | |
|
| Compound |
| Calcium cation | | Fumarate | | (S)-Malate | | Diacylglycerol | | Cholesterol | | Androstenedione | | Progesterone | | Phosphatidate | | Testosterone | | Cortisol | | Cortisone | | Retinoate | | Estradiol-17beta | | Dehydroepiandrosterone | | D-myo-Inositol 1,4,5-trisphosphate | | Dihydrotestosterone | | Phosphatidylinositol-3,4,5-trisphosphate | | Flutamide | | 9-cis-Retinoic acid | | 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine |
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