KEGG   PATHWAY: ko05200Help
Entry
ko05200                     Pathway                                

Name
Pathways in cancer
Class
Human Diseases; Cancers
BRITE hierarchy
Pathway map
Pathways in cancer
ko05200

All organismsOrtholog table
Disease
H00559  
von Hippel-Lindau syndrome
H00646  
Odontoonychodermal dysplasia
H00857  
Oligodontia-colorectal cancer syndrome
H00881  
Li-Fraumeni syndrome
H00895  
Basal cell nevus syndrome
H00947  
Pilomatricoma
H01007  
Choroid plexus papilloma
H01023  
Juvenile polyposis syndrome
H01025  
Familial adenomatous polyposis
Orthology
K06765  
deleted in colorectal carcinoma
K02187  
caspase 3 [EC:3.4.22.56]
K04399  
caspase 9 [EC:3.4.22.62]
K08733  
DCC-interacting protein 13 alpha
K05689  
cadherin 1, type 1, E-cadherin
K02105  
catenin beta 1
K05691  
catenin alpha
K02157  
axin 1
K04385  
axin 2
K02085  
adenomatosis polyposis coli protein
K03083  
glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02620  
transcription factor 7
K04490  
transcription factor 7-like 1
K04491  
transcription factor 7-like 2
K04492  
lymphoid enhancer-binding factor 1
K08731  
baculoviral IAP repeat-containing protein 5
K04377  
Myc proto-oncogene protein
K04503  
cyclin D1
K03209  
wingless-type MMTV integration site family, member 1
K00182  
wingless-type MMTV integration site family, member 2
K00312  
wingless-type MMTV integration site family, member 3
K00408  
wingless-type MMTV integration site family, member 4
K00444  
wingless-type MMTV integration site family, member 5
K00445  
wingless-type MMTV integration site family, member 6
K00572  
wingless-type MMTV integration site family, member 7
K00714  
wingless-type MMTV integration site family, member 8
K01064  
wingless-type MMTV integration site family, member 9
K01357  
wingless-type MMTV integration site family, member 10
K01384  
wingless-type MMTV integration site family, member 11
K01558  
wingless-type MMTV integration site family, member 16
K02432  
frizzled 1/7
K02235  
frizzled 2
K02329  
frizzled 3
K02354  
frizzled 4
K02375  
frizzled 5/8
K02376  
frizzled 6
K02842  
frizzled 9/10
K02353  
segment polarity protein dishevelled
K06237  
collagen, type IV, alpha
K05637  
laminin, alpha 1/2
K06240  
laminin, alpha 3/5
K06241  
laminin, alpha 4
K05636  
laminin, beta 1
K06243  
laminin, beta 2
K06244  
laminin, beta 3
K06245  
laminin, beta 4
K05635  
laminin, gamma 1
K06246  
laminin, gamma 2
K06247  
laminin, gamma 3
K05717  
fibronectin 1
K06481  
integrin alpha 2
K06476  
integrin alpha 2B
K06482  
integrin alpha 3
K06485  
integrin alpha 6
K06487  
integrin alpha V
K05719  
integrin beta 1
K05725  
focal adhesion kinase 1 [EC:2.7.10.2]
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649  
phosphoinositide-3-kinase, regulatory subunit
K01110  
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.67 3.1.3.48 3.1.3.16]
K09348  
homeobox protein Nkx-3.1
K04456  
RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467  
inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209  
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210  
inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734  
NF-kappa-B inhibitor alpha
K02580  
nuclear factor NF-kappa-B p105 subunit
K04469  
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04735  
transcription factor p65
K11987  
prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K13241  
nitric-oxide synthase, inducible [EC:1.14.13.39]
K02161  
apoptosis regulator BCL-2
K16060  
baculoviral IAP repeat-containing protein 2/3
K04725  
E3 ubiquitin-protein ligase XIAP
K16061  
baculoviral IAP repeat-containing protein 7/8
K04570  
BCL2-like 1 (apoptosis regulator Bcl-X)
K03172  
TNF receptor-associated factor 1
K03173  
TNF receptor-associated factor 2
K03174  
TNF receptor-associated factor 3
K09848  
TNF receptor-associated factor 4
K09849  
TNF receptor-associated factor 5
K03175  
TNF receptor-associated factor 6
K07203  
FKBP12-rapamycin complex-associated protein
K02158  
BCL2-antagonist of cell death
K07201  
forkhead box protein O1
K06643  
E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
K04451  
tumor protein p53
K06624  
cyclin-dependent kinase inhibitor 1B
K06625  
cyclin-dependent kinase inhibitor 1A
K08878  
breakpoint cluster region protein [EC:2.7.11.1]
K06619  
abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K04438  
proto-oncogene C-crk
K04707  
E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
K11223  
signal transducer and activator of transcription 5A
K11224  
signal transducer and activator of transcription 5B
K11217  
Janus kinase 1 [EC:2.7.10.2]
K04692  
signal transducer and activator of transcription 3
K11220  
signal transducer and activator of transcription 1
K05448  
vascular endothelial growth factor A
K16858  
vascular endothelial growth factor B
K16859  
placenta growth factor
K05449  
vascular endothelial growth factor C/D
K08774  
transforming growth factor, alpha
K04357  
epidermal growth factor
K04361  
epidermal growth factor receptor [EC:2.7.10.1]
K05083  
receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K04359  
platelet derived growth factor A/B
K04363  
platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089  
platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05459  
insulin-like growth factor 1
K05087  
insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05461  
KIT ligand
K05091  
proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05454  
fms-related tyrosine kinase 3 ligand
K05092  
fms-related tyrosine kinase 3 [EC:2.7.10.1]
K05460  
hepatocyte growth factor
K05099  
proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K04358  
fibroblast growth factor
K04362  
fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093  
fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094  
fibroblast growth factor receptor 3 [EC:2.7.10.1]
K04364  
growth factor receptor-binding protein 2
K03099  
son of sevenless
K02833  
GTPase HRas
K07827  
GTPase KRas
K07828  
GTPase NRas
K08845  
A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365  
B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366  
RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368  
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  
mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  
extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K04448  
transcription factor AP-1
K04379  
proto-oncogene protein c-fos
K01388  
matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K01398  
matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
K01403  
matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
K10030  
interleukin 8
K02089  
cyclin-dependent kinase 4 [EC:2.7.11.22]
K05126  
proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K09288  
coiled-coil domain-containing protein 6
K09289  
nuclear receptor coactivator 4
K03176  
neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K09290  
tropomyosin 3
K09291  
nucleoprotein TPR
K09292  
protein TFG
K09850  
Ras association domain-containing protein 1
K08015  
Ras association domain-containing protein 5
K04411  
serine/threonine kinase 4
K08803  
death-associated protein kinase [EC:2.7.11.1]
K01116  
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859  
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K02677  
classical protein kinase C [EC:2.7.11.13]
K08732  
ral guanine nucleotide dissociation stimulator
K07834  
Ras-related protein Ral-A
K07835  
Ras-related protein Ral-B
K08773  
RalA-binding protein 1
K04393  
cell division control protein 42
K04392  
Ras-related C3 botulinum toxin substrate 1
K07860  
Ras-related C3 botulinum toxin substrate 2
K07861  
Ras-related C3 botulinum toxin substrate 3
K04513  
Ras homolog gene family, member A
K04440  
c-Jun N-terminal kinase [EC:2.7.11.24]
K09293  
paired box protein 8
K08530  
peroxisome proliferator-activated receptor gamma
K08524  
retinoid X receptor alpha
K08525  
retinoid X receptor beta
K08526  
retinoid X receptor gamma
K08528  
retinoic acid receptor beta
K04504  
peroxisome proliferator-activated receptor delta
K10056  
junction plakoglobin
K10055  
zinc finger and BTB domain-containing protein 16
K10054  
probable transcription factor PML
K08527  
retinoic acid receptor alpha
K08367  
runt-related transcription factor 1
K10053  
runt-related transcription factor 1; translocated to, 1
K09438  
transcription factor PU.1
K09055  
CCAAT/enhancer binding protein (C/EBP), alpha
K05066  
granulocyte-macrophage colony-stimulating factor receptor alpha
K05061  
granulocyte colony-stimulating factor receptor
K05090  
macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K05405  
interleukin 6
K06621  
cyclin-dependent kinase inhibitor 2A
K06620  
E2F transcription factor 1/3
K09389  
E2F transcription factor 2
K04453  
Max protein
K16063  
E3 SUMO-protein ligase PIAS2 [EC:6.3.2.-]
K04685  
cyclin-dependent kinase inhibitor 2B
K02091  
cyclin-dependent kinase 6 [EC:2.7.11.22]
K02219  
cyclin-dependent kinase regulatory subunit CKS1
K03875  
F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K02206  
cyclin-dependent kinase 2 [EC:2.7.11.22]
K06626  
cyclin E
K06618  
retinoblastoma-associated protein
K09455  
microphthalmia-associated transcription factor
K13375  
transforming growth factor beta-1
K13376  
transforming growth factor beta-2
K13377  
transforming growth factor beta-3
K04674  
TGF-beta receptor type-1 [EC:2.7.11.30]
K04388  
TGF-beta receptor type-2 [EC:2.7.11.30]
K04500  
mothers against decapentaplegic homolog 2/3
K04501  
mothers against decapentaplegic homolog 4
K04462  
ecotropic virus integration site 1 protein
K04496  
C-terminal binding protein
K06067  
histone deacetylase 1/2 [EC:3.5.1.98]
K08734  
DNA mismatch repair protein MLH1
K08735  
DNA mismatch repair protein MSH2
K08736  
DNA mismatch repair protein MSH3
K08737  
DNA mismatch repair protein MSH6
K02159  
apoptosis regulator BAX
K08775  
breast cancer 2 susceptibility protein
K04482  
DNA repair protein RAD51
K04389  
tumor necrosis factor ligand superfamily member 6
K04390  
tumor necrosis factor receptor superfamily member 6
K02373  
FAS-associated death domain protein
K04398  
caspase 8 [EC:3.4.22.61]
K04726  
BH3 interacting domain death agonist
K08738  
cytochrome c
K03871  
von Hippel-Lindau disease tumor supressor
K03872  
transcription elongation factor B, polypeptide 1
K03873  
transcription elongation factor B, polypeptide 2
K03868  
RING-box protein 1
K03870  
cullin 2
K09592  
hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.-]
K01679  
fumarate hydratase, class II [EC:4.2.1.2]
K08268  
hypoxia-inducible factor 1 alpha
K09095  
hypoxia-inducible factor 2 alpha
K09097  
aryl hydrocarbon receptor nuclear translocator
K15589  
aryl hydrocarbon receptor nuclear translocator 2
K04498  
E1A/CREB-binding protein [EC:2.3.1.48]
K07299  
MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K11988  
sonic hedgehog
K06225  
patched 1
K06226  
smoothened
K06227  
costal 2
K06228  
fused [EC:2.7.11.1]
K06229  
suppressor of fused
K16797  
zinc finger protein GLI1
K16798  
zinc finger protein GLI2
K06230  
zinc finger protein GLI3
K04662  
bone morphogenetic protein 2/4
K06231  
hedgehog interacting protein
K11101  
patched 2
K08557  
androgen receptor
K04079  
molecular chaperone HtpG
K09487  
heat shock protein 90kDa beta
K01351  
semenogelase [EC:3.4.21.77]
Compound
C00076  
Calcium cation
C00122  
Fumarate
C00149  
(S)-Malate
C00165  
Diacylglycerol
C00187  
Cholesterol
C00280  
Androstenedione
C00410  
Progesterone
C00416  
Phosphatidate
C00535  
Testosterone
C00735  
Cortisol
C00762  
Cortisone
C00777  
Retinoate
C00951  
Estradiol-17beta
C01227  
Dehydroepiandrosterone
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C03917  
Dihydrotestosterone
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C07653  
Flutamide
C15493  
9-cis-Retinoic acid
C16038  
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
Reference
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Colorectal cancer: genetics of development and metastasis.
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Hereditary colorectal cancer.
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