KEGG   PATHWAY: kpe02060Help
kpe02060                    Pathway                                

Phosphotransferase system (PTS) - Klebsiella pneumoniae 342
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Environmental Information Processing; Membrane transport
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Pathway map
kpe02060  Phosphotransferase system (PTS)

Ortholog table
kpe_M00265  PTS system, glucose-specific II component [PATH:kpe02060]
kpe_M00266  PTS system, maltose/glucose-specific II component [PATH:kpe02060]
kpe_M00267  PTS system, N-acetylglucosamine-specific II component [PATH:kpe02060]
kpe_M00268  PTS system, alpha-glucoside-specific II component [PATH:kpe02060]
kpe_M00270  PTS system, trehalose-specific II component [PATH:kpe02060]
kpe_M00271  PTS system, beta-glucoside-specific II component [PATH:kpe02060]
kpe_M00272  PTS system, beta-glucoside (arbutin/salicin/cellobiose)-specific II component [PATH:kpe02060]
kpe_M00273  PTS system, fructose-specific II component [PATH:kpe02060]
kpe_M00274  PTS system, mannitol-specific II component [PATH:kpe02060]
kpe_M00275  PTS system, cellobiose-specific II component [PATH:kpe02060]
kpe_M00276  PTS system, mannose-specific II component [PATH:kpe02060]
kpe_M00278  PTS system, sorbose-specific II component [PATH:kpe02060]
kpe_M00280  PTS system, glucitol/sorbitol-specific II component [PATH:kpe02060]
kpe_M00283  PTS system, ascorbate-specific II component [PATH:kpe02060]
kpe_M00303  PTS system, N-acetylmuramic acid-specific II component [PATH:kpe02060]
kpe_M00764  PTS system, fructoselysine/glucoselysine-specific II component [PATH:kpe02060]
Other DBs
BSID: 74873
GO: 0009401
TC: 4.A
Klebsiella pneumoniae 342 [GN:kpe]
KPK_1375  ptsI; phosphoenolpyruvate-protein phosphotransferase [KO:K08483] [EC:]
KPK_3550  ptsA; multiphosphoryl transfer protein 2 [KO:K08483 K11189 K11201] [EC: 2.7.1.-]
KPK_1376  pstH; phosphocarrier protein HPr [KO:K02784]
KPK_1374  crr; glucose-specific phosphotransferase enzyme IIA component [KO:K02777] [EC:2.7.1.-]
KPK_4248  PTS system, IIB component [KO:K02778] [EC:]
KPK_3457  ptsG; PTS system, glucose-specific IIBC component [KO:K02778 K02779] [EC:]
KPK_3873  nagE; PTS system, N-acetylglucosamine-specific IIBC component [KO:K02802 K02803 K02804] [EC:]
KPK_2947  malX; PTS system, maltose and glucose-specific IIBC component [KO:K02790 K02791] [EC:]
KPK_5352  PTS system, IIBC component [KO:K02809 K02810] [EC:]
KPK_4073  scrA; PTS system sucrose-specific EIIBC component [KO:K02809 K02810] [EC:]
KPK_2586  PTS system, beta-glucoside-specific IIABC component [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
KPK_1590  bglF; PTS system, beta-glucoside-specific EIIBCA component [KO:K02755 K02756 K02757] [EC:2.7.1.- 2.7.1.-]
KPK_1071  ascF; PTS system, arbutin-, cellobiose-, and salicin-specific EIIBC component [KO:K02752 K02753] [EC:2.7.1.-]
KPK_0014  aglA; PTS system, alpha-glucoside-specific EIICB component [KO:K02749 K02750] [EC:2.7.1.-]
KPK_2683  PTS system, glucose-like IIBC component [KO:K02749 K02750] [EC:2.7.1.-]
KPK_0081  PTS system, IIBC component [KO:K02749 K02750] [EC:2.7.1.-]
KPK_5016  treB; PTS system, trehalose-specific IIBC component [KO:K02818 K02819] [EC:]
KPK_0050  murP; PTS system, N-acetylmuramic acid-specific EIIBC component [KO:K11191 K11192] [EC:]
KPK_0153  mtlA; PTS system mannitol-specific EIICBA component [KO:K02798 K02799 K02800] [EC:]
KPK_B0039  cmtA; PTS system, mannitol-specific EIICB component [KO:K02799 K02800] [EC:]
KPK_3209  chbA; PTS system, N,N'-diacetylchitobiose-specific EIIA component [KO:K02759] [EC:]
KPK_1431  PTS system, lactose/cellobiose specific IIA subunit [KO:K02759] [EC:]
KPK_1047  PTS system, lactose/cellobiose specific IIA subunit [KO:K02759] [EC:]
KPK_5306  PTS system, lactose/cellobiose specific IIA subunit [KO:K02759] [EC:]
KPK_0037  PTS system, lactose/cellobiose specific IIA subunit [KO:K02759] [EC:]
KPK_3212  chbB; PTS system, N,N'-diacetylchitobiose-specific IIB component [KO:K02760] [EC:]
KPK_A0129  PTS system, lactose/cellobiose specific IIB subunit [KO:K02760] [EC:]
KPK_0039  PTS system, lactose/cellobiose family IIB subunit [KO:K02760] [EC:]
KPK_1429  PTS system, lactose/cellobiose specific IIB subunit [KO:K02760] [EC:]
KPK_1049  PTS system, lactose/cellobiose specific IIB subunit [KO:K02760] [EC:]
KPK_5305  PTS system, lactose/cellobiose specific IIB subunit [KO:K02760] [EC:]
KPK_3210  chbC; PTS system, N,N'-diacetylchitobiose-specific EIIC component [KO:K02761]
KPK_1430  PTS system, lactose/cellobiose family IIC component [KO:K02761]
KPK_1048  PTS system, lactose/cellobiose family IIC subunit [KO:K02761]
KPK_1050  PTS system, lactose/cellobiose family IIC component [KO:K02761]
KPK_0864  PTS system, lactose/cellobiose family IIC component [KO:K02761]
KPK_4794  PTS system, lactose/cellobiose family IIC component [KO:K02761]
KPK_0038  PTS system, lactose/cellobiose family IIC subunit [KO:K02761]
KPK_A0130  PTS system, lactose/cellobiose family IIC component [KO:K02761]
KPK_1960  manX; PTS system mannose-specific EIIAB component [KO:K02793 K02794] [EC:]
KPK_1959  manY; mannose permease IIC component [KO:K02795]
KPK_1958  manZ; mannose permease IID component [KO:K02796]
KPK_4812  PTS system, IIA component [KO:K19506] [EC:2.7.1.-]
KPK_4811  PTS system, IIB component [KO:K19507] [EC:2.7.1.-]
KPK_4810  PTS system, IIC component [KO:K19508]
KPK_4809  PTS system, IID component [KO:K19509]
KPK_5268  sorF; sorbose-specific phosphotransferase enzyme IIA component [KO:K02812] [EC:]
KPK_5269  sorB; sorbose-specific phosphotransferase enzyme IIB component [KO:K02813] [EC:]
KPK_5270  sorA; sorbose permease IIC component [KO:K02814]
KPK_5271  sorM; sorbose permease IID component [KO:K02815]
KPK_1087  srlB; glucitol/sorbitol-specific phosphotransferase enzyme IIA component [KO:K02781] [EC:]
KPK_3429  PTS system, glucitol/sorbitol-specific IIA component [KO:K02781] [EC:]
KPK_1088  srlE; glucitol/sorbitol-specific phosphotransferase enzyme IIB component [KO:K02782 K02783] [EC:]
KPK_1089  srlA; glucitol/sorbitol permease IIC component [KO:K02783]
KPK_4470  putative PTS system, galactitol-specific IIC component [KO:K02775]
KPK_4333  PTS system, IIA component [KO:K02821] [EC:]
KPK_5079  ulaC; ascorbate-specific phosphotransferase enzyme IIA component [KO:K02821] [EC:]
KPK_B0036  cmtB; PTS system, mannitol-specific EIIA component [KO:K02821] [EC:]
KPK_5484  PTS system, IIA component [KO:K02821] [EC:]
KPK_4334  PTS system, IIB component [KO:K02822] [EC:]
KPK_5080  ulaB; ascorbate-specific phosphotransferase enzyme IIB component [KO:K02822] [EC:]
KPK_5488  PTS system, IIB component [KO:K02822] [EC:]
KPK_4335  putative sugar-specific permease, SgaT/UlaA family [KO:K03475]
KPK_5081  ulaA; ascorbate-specific permease IIC component [KO:K03475]
KPK_5487  putative sugar-specific permease, SgaT/UlaA family [KO:K03475]
KPK_1566  fruB; PTS system fructose-specific phosphotransferase enzyme IIA component [KO:K02768 K11183] [EC:]
KPK_1568  fruA; PTS system fructose-specific EIIBC component [KO:K02769 K02770] [EC:]
KPK_0877  ptsP; phosphoenolpyruvate-protein phosphotransferase [KO:K08484] [EC:]
KPK_0505  ptsO; phosphocarrier protein NPr [KO:K08485]
KPK_0507  ptsN; PTS IIA-like nitrogen-regulatory protein PtsN [KO:K02806] [EC:2.7.1.-]
C00022  Pyruvate
C00031  D-Glucose
C00072  Ascorbate
C00074  Phosphoenolpyruvate
C00089  Sucrose
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00124  D-Galactose
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00185  Cellobiose
C00208  Maltose
C00243  Lactose
C00275  D-Mannose 6-phosphate
C00329  D-Glucosamine
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00392  Mannitol
C00644  D-Mannitol 1-phosphate
C00689  alpha,alpha'-Trehalose 6-phosphate
C00697  Nitrogen
C00794  D-Sorbitol
C01083  alpha,alpha-Trehalose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01113  D-Galactose 6-phosphate
C01132  N-Acetyl-D-galactosamine
C01451  Salicin
C01452  Sorbose
C01674  Chitobiose
C01697  Galactitol
C01798  D-Glucoside
C02262  D-Galactosamine
C02713  N-Acetylmuramate
C02888  Sorbose 1-phosphate
C02995  Maltose 6'-phosphate
C03752  2-Amino-2-deoxy-D-gluconate
C04534  6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C05396  Lactose 6'-phosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C06311  Galactitol 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C16186  L-Ascorbate 6-phosphate
C16488  Fructoselysine
C16489  Fructoselysine 6-phosphate
C16688  Sucrose 6-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C16699  2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  D-Glucosaminate-6-phosphate
C20978  Glucoselysine
C20979  Glucoselysine-6-phosphate
C21152  N,N'-Diacetylchitobiose 6'-phosphate
Darbon E, Galinier A, Le Coq D, Deutscher J.
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
J Mol Microbiol Biotechnol 3:439-44 (2001)
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
J Bacteriol 186:2385-92 (2004)
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
J Mol Biol 214:657-71 (1990)
Kristich CJ, Glekas GD, Ordal GW.
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
Mol Microbiol 47:1353-66 (2003)
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
J Biol Chem 279:5537-48 (2004)
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
EcoCyc: a comprehensive database resource for Escherichia coli.
Nucleic Acids Res 33:D334-7 (2005)
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
J Bacteriol 190:1710-7 (2008)
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
Mol Microbiol 37:125-35 (2000)
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
The complete phosphotranferase system in Escherichia coli.
J Mol Microbiol Biotechnol 3:329-46 (2001)
Kotrba P, Inui M, Yukawa H.
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
J Biosci Bioeng 92:502-17 (2001)
KO pathway

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