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kpn03440                    Pathway                                

Homologous recombination - Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Genetic Information Processing; Replication and repair
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Homologous recombination

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DNA polymerase III complex, bacteria [PATH:kpn03440]
Other DBs
Klebsiella pneumoniae subsp. pneumoniae MGH 78578 [GN:kpn]
recJ; ssDNA exonuclease, 5' --> 3' specific [KO:K07462] [EC:3.1.-.-]
ssb; single-strand DNA-binding protein [KO:K03111]
ssb; single-strand binding protein [KO:K03111]
ssb; single-stranded binding protein [KO:K03111]
recF; recombination protein F [KO:K03629]
recO; DNA repair protein RecO [KO:K03584]
recR; recombination protein RecR [KO:K06187]
recA; recombinase A [KO:K03553]
polA; DNA polymerase I [KO:K02335] [EC:]
ruvA; Holliday junction DNA helicase motor protein [KO:K03550] [EC:]
ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:]
ruvC; Holliday junction resolvase [KO:K01159] [EC:]
recG; DNA helicase, ATP-dependent resolution of Holliday junctions, branch migration [KO:K03655] [EC:]
recB; DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease [KO:K03582] [EC:]
recC; DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease [KO:K03583] [EC:]
recD; DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease [KO:K03581] [EC:]
dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:]
dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:]
dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:]
holA; DNA polymerase III subunit delta [KO:K02340] [EC:]
holB; DNA polymerase III subunit delta [KO:K02341] [EC:]
dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:]
holE; DNA polymerase III, theta subunit [KO:K02345] [EC:]
putative inner membrane protein [KO:K02345] [EC:]
hypothetical protein [KO:K02345] [EC:]
hypothetical protein [KO:K02345] [EC:]
holC; DNA polymerase III subunit chi [KO:K02339] [EC:]
holD; DNA polymerase III subunit psi [KO:K02344] [EC:]
priA; primosome assembly protein PriA [KO:K04066] [EC:3.6.4.-]
priB; primosomal replication protein N [KO:K02686]
priC; primosomal replication protein N'' [KO:K04067]
dnaT; primosomal protein I [KO:K02317]
Maloisel L, Fabre F, Gangloff S.
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Mol Cell Biol 28:1373-82 (2008)
Haruta-Takahashi N, Iwasaki H.
[Recombination mediators] Japanese
Seikagaku 79:449-53 (2007)
Ouyang KJ, Woo LL, Ellis NA.
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Mech Ageing Dev 129:425-40 (2008)
Kawabata M, Kawabata T, Nishibori M.
Role of recA/RAD51 family proteins in mammals.
Acta Med Okayama 59:1-9 (2005)
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Mitotic recombination in Saccharomyces cerevisiae.
Curr Genet 42:185-98 (2003)
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Rad54: the Swiss Army knife of homologous recombination?
Nucleic Acids Res 34:4115-25 (2006)
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Recombination proteins and rescue of arrested replication forks.
DNA Repair (Amst) 6:967-80 (2007)
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