KEGG   PATHWAY: kra03440
Entry
kra03440                    Pathway                                
Name
Homologous recombination - Kineococcus radiotolerans
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
kra03440  Homologous recombination
kra03440

Other DBs
GO: 0000724
Organism
Kineococcus radiotolerans [GN:kra]
Gene
Krad_4338  single-strand binding protein [KO:K03111]
Krad_0004  DNA replication and repair protein RecF [KO:K03629]
Krad_3375  DNA repair protein RecO [KO:K03584]
Krad_0465  recombination protein RecR [KO:K06187]
Krad_1492  recA protein [KO:K03553]
Krad_2951  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Krad_3054  Holliday junction DNA helicase RuvA [KO:K03550]
Krad_3053  Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
Krad_3056  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Krad_1368  DEAD/DEAH box helicase domain protein [KO:K03655] [EC:5.6.2.4]
Krad_0360  putative transcriptional regulator [KO:K03655] [EC:5.6.2.4]
Krad_0993  exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
Krad_0992  exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
Krad_0994  exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
Krad_3187  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Krad_1769  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Krad_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Krad_0466  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Krad_3422  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Krad_0490  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
Krad_3247  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Krad_4419  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Krad_4659  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Krad_2988  primosomal protein N' (replication factor Y) [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG GENES (24)   
All databases (25)   

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