KEGG   PATHWAY: lca03410Help
Entry
lca03410                    Pathway                                
Name
Base excision repair - Lactobacillus casei ATCC 334
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Base excision repair
lca03410

All organismsOrtholog table
Module
DNA polymerase delta complex [PATH:lca03410]
BER complex [PATH:lca03410]
Other DBs
Organism
Lactobacillus casei ATCC 334 [GN:lca]
Gene
formamidopyrimidine-DNA glycosylase; K10563 formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18] [KO:K10563] [EC:4.2.99.18 3.2.2.23]
EndoIII-related endonuclease; K10773 endonuclease III [EC:4.2.99.18] [KO:K10773] [EC:4.2.99.18]
3-methyladenine DNA glycosylase; K01246 DNA-3-methyladenine glycosylase I [EC:3.2.2.20] [KO:K01246] [EC:3.2.2.20]
3-methyladenine DNA glycosylase; K01246 DNA-3-methyladenine glycosylase I [EC:3.2.2.20] [KO:K01246] [EC:3.2.2.20]
uracil-DNA glycosylase; K03648 uracil-DNA glycosylase [EC:3.2.2.27] [KO:K03648] [EC:3.2.2.27]
A/G-specific DNA glycosylase; K03575 A/G-specific adenine glycosylase [EC:3.2.2.-] [KO:K03575] [EC:3.2.2.-]
3-methyladenine DNA glycosylase; K03652 DNA-3-methyladenine glycosylase [EC:3.2.2.21] [KO:K03652] [EC:3.2.2.21]
exonuclease III; K01142 exodeoxyribonuclease III [EC:3.1.11.2] [KO:K01142] [EC:3.1.11.2]
endonuclease IV; K01151 deoxyribonuclease IV [EC:3.1.21.2] [KO:K01151] [EC:3.1.21.2]
DNA polymerase I; K02335 DNA polymerase I [EC:2.7.7.7] [KO:K02335] [EC:2.7.7.7]
single-stranded DNA-specific exonuclease; K07462 single-stranded-DNA-specific exonuclease [EC:3.1.-.-] [KO:K07462] [EC:3.1.-.-]
NAD-dependent DNA ligase; K01972 DNA ligase (NAD+) [EC:6.5.1.2] [KO:K01972] [EC:6.5.1.2]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
 
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