KEGG   PATHWAY: lch03440Help
Entry
lch03440                    Pathway                                

Name
Homologous recombination - Leptothrix cholodnii
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
lch03440  Homologous recombination
lch03440

Ortholog table
Module
lch_M00260  DNA polymerase III complex, bacteria [PATH:lch03440]
Other DBs
BSID: 66596
GO: 0000724
Organism
Leptothrix cholodnii [GN:lch]
Gene
Lcho_2400  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Lcho_0555  single-strand binding protein [KO:K03111]
Lcho_0596  DNA repair protein RecO [KO:K03584]
Lcho_1974  recombination protein RecR [KO:K06187]
Lcho_0497  recA protein [KO:K03553]
Lcho_1062  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Lcho_3953  Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
Lcho_3954  Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
Lcho_0531  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
Lcho_1580  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
Lcho_1777  exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
Lcho_1776  exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
Lcho_1778  exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
Lcho_0980  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Lcho_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Lcho_1976  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Lcho_0481  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Lcho_1879  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
Lcho_0238  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Lcho_1041  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Lcho_2503  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Lcho_0024  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Lcho_2594  DNA polymerase III chi subunit HolC [KO:K02339] [EC:2.7.7.7]
Lcho_3523  primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Lcho_2829  primosomal replication protein N [KO:K02686]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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