KEGG   PATHWAY: ldb03440
Entry
ldb03440                    Pathway                                
Name
Homologous recombination - Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ldb03440  Homologous recombination
ldb03440

Other DBs
GO: 0000724
Organism
Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 [GN:ldb]
Gene
Ldb1309  recJ; RecJ, single-stranded DNA specific exonuclease [KO:K07462] [EC:3.1.-.-]
Ldb0008  ssb; Single-stranded DNA-binding protein [KO:K03111]
Ldb0004  recF; DNA replication and repair protein RecF [KO:K03629]
Ldb1250  recO; DNA repair protein RecO (Recombination protein O) [KO:K03584]
Ldb1633  recR; Recombination protein RecR [KO:K06187]
Ldb0599  recA; RecA protein (Recombinase A) [KO:K03553]
Ldb1512  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Ldb1614  ruvA; Holliday junction DNA helicase RuvA [KO:K03550]
Ldb1613  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
Ldb1389  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Ldb0308  Putative transcriptional regulator (Crp family) [KO:K03655] [EC:5.6.2.4]
Ldb0758  recD; Exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
Ldb0837  dnaE; DNA polymerase III, alpha subunit (DnaE) [KO:K02337] [EC:2.7.7.7]
Ldb1337  polC; DNA polymerase III, alpha subunit (gram-positive type) (PolC) [KO:K03763] [EC:2.7.7.7]
Ldb0002  dnaN; DNA polymerase III, beta chain [KO:K02338] [EC:2.7.7.7]
Ldb1635  dnaX; DNA polymerase III, gamma/tau subunit [KO:K02343] [EC:2.7.7.7]
Ldb0771  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Ldb1629  Conserved hypothetical protein [KO:K02341] [EC:2.7.7.7]
Ldb0645  Putative exonuclease [KO:K02342] [EC:2.7.7.7]
Ldb1162  Putative exonuclease [KO:K02342] [EC:2.7.7.7]
Ldb1413  priA; PriA (Primosomal protein N') [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG GENES (21)   
All databases (22)   

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