KEGG   PATHWAY: lla00030Help
Entry
lla00030                    Pathway                                

Name
Pentose phosphate pathway - Lactococcus lactis subsp. lactis IL1403
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Pentose phosphate pathway
lla00030

All organismsOrtholog table
Module
PRPP biosynthesis, ribose 5P => PRPP [PATH:lla00030]
Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:lla00030]
D-Glucuronate degradation, D-glucuronate => pyruvate + D-glyceraldehyde 3P [PATH:lla00030]
Other DBs
BSID: 
GO: 
Organism
Lactococcus lactis subsp. lactis IL1403 [GN:lla]
Gene
L0012  
pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
L0044  
zwf; glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49]
L11851  
ywcC; hypothetical protein [KO:K07404] [EC:3.1.1.31]
L53699  
gntZ; 6-phosphogluconate dehydrogenase [KO:K00033] [EC:1.1.1.44]
L0046  
gnd; 6-phosphogluconate dehydrogenase [KO:K00033] [EC:1.1.1.44]
L0047  
rpe; ribulose-phosphate 3-epimerase [KO:K01783] [EC:5.1.3.1]
L0043  
tkt; transketolase [KO:K00615] [EC:2.2.1.1]
L0045  
rpiA; ribose-5-phosphate isomerase A [KO:K01807] [EC:5.3.1.6]
L63310  
deoC; deoxyribose-phosphate aldolase [KO:K01619] [EC:4.1.2.4]
L86157  
rbsK; ribokinase [KO:K00852] [EC:2.7.1.15]
deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
prsB; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
L25614  
prsA; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
L0022  
kdgA; keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.3.42 4.1.2.14]
L52019  
gntK; gluconate kinase [KO:K00851] [EC:2.7.1.12]
L0021  
kdgK; 2-dehydro-3-deoxygluconokinase [KO:K00874] [EC:2.7.1.45]
L0009  
fbaA; fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
L54021  
fbp; fructose-1,6-bisphosphatase [KO:K04041] [EC:3.1.3.11]
L0002  
pfkA; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
Compound
C00022  
Pyruvate
C00031  
D-Glucose
C00117  
D-Ribose 5-phosphate
C00118  
D-Glyceraldehyde 3-phosphate
C00119  
5-Phospho-alpha-D-ribose 1-diphosphate
C00121  
D-Ribose
C00197  
3-Phospho-D-glycerate
C00198  
D-Glucono-1,5-lactone
C00199  
D-Ribulose 5-phosphate
C00204  
2-Dehydro-3-deoxy-D-gluconate
C00221  
beta-D-Glucose
C00231  
D-Xylulose 5-phosphate
C00257  
D-Gluconic acid
C00258  
D-Glycerate
C00279  
D-Erythrose 4-phosphate
C00345  
6-Phospho-D-gluconate
C00577  
D-Glyceraldehyde
C00620  
alpha-D-Ribose 1-phosphate
C00631  
2-Phospho-D-glycerate
C00668  
alpha-D-Glucose 6-phosphate
C00672  
2-Deoxy-D-ribose 1-phosphate
C00673  
2-Deoxy-D-ribose 5-phosphate
C01151  
D-Ribose 1,5-bisphosphate
C01172  
beta-D-Glucose 6-phosphate
C01218  
6-Phospho-2-dehydro-D-gluconate
C01236  
D-Glucono-1,5-lactone 6-phosphate
C01801  
Deoxyribose
C03752  
2-Amino-2-deoxy-D-gluconate
C04442  
2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05345  
beta-D-Fructose 6-phosphate
C05378  
beta-D-Fructose 1,6-bisphosphate
C05382  
Sedoheptulose 7-phosphate
C06019  
D-arabino-Hex-3-ulose 6-phosphate
C06473  
2-Keto-D-gluconic acid
C20589  
D-Glucosaminate-6-phosphate
Reference
(map 3)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 4)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate  pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
Reference
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
Reference
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
Reference
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
KO pathway
 

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