KEGG   PATHWAY: lps03440Help
Entry
lps03440                    Pathway                                

Name
Homologous recombination - Lactobacillus plantarum subsp. plantarum ST-III
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
lps03440  Homologous recombination
lps03440

Ortholog table
Module
lps_M00260  DNA polymerase III complex, bacteria [PATH:lps03440]
Other DBs
BSID: 171623
GO: 0000724
Organism
Lactobacillus plantarum subsp. plantarum ST-III [GN:lps]
Gene
LPST_C1720  recJ; single-strand DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
LPST_C0008  ssb; single-strand binding protein [KO:K03111]
LPST_C0004  recF; recombination protein F [KO:K03629]
LPST_C1583  recO; DNA repair protein RecO [KO:K03584]
LPST_C0532  recR; recombination protein RecR [KO:K06187]
LPST_C1905  recA; recombinase A [KO:K03553]
LPST_C1188  polA; DNA-directed DNA polymerase I [KO:K02335] [EC:2.7.7.7]
LPST_C1896  ruvA; crossover junction ATP-dependent DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
LPST_C1895  ruvB; Holliday junction DNA helicase B [KO:K03551] [EC:3.6.4.12]
LPST_C1292  recG; DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
LPST_C1787  recD; exodeoxyribonuclease V alpha subunit [KO:K03581] [EC:3.1.11.5]
LPST_C1525  dnaE; DNA-directed DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
LPST_C1635  polC; DNA polymerase III PolC [KO:K03763] [EC:2.7.7.7]
LPST_C0002  dnaN; DNA-directed DNA polymerase III, beta chain [KO:K02338] [EC:2.7.7.7]
LPST_C0530  dnaX; DNA polymerase III, gamma/tau subunit DnaX [KO:K02343] [EC:2.7.7.7]
LPST_C1757  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
LPST_C0536  holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
LPST_C0633  DNA-directed DNA polymerase III, epsilon chain (putative) [KO:K02342] [EC:2.7.7.7]
LPST_C1280  priA; DNA replication factor Y [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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