KEGG   PATHWAY: lsg03440Help
Entry
lsg03440                    Pathway                                

Name
Homologous recombination - Listeria seeligeri
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
lsg03440  Homologous recombination
lsg03440

Ortholog table
Module
lsg_M00260  DNA polymerase III complex, bacteria [PATH:lsg03440]
Other DBs
BSID: 145642
GO: 0000724
Organism
Listeria seeligeri [GN:lsg]
Gene
lse_1440  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
lse_2423  ssb-2; single-strand binding protein [KO:K03111]
lse_0034  ssb; Single-strand binding protein [KO:K03111]
lse_0005  recF; DNA replication and repair protein [KO:K03629]
lse_1377  recO; recombination protein O [KO:K03584]
lse_2616  recR; Recombination protein recR [KO:K06187]
lse_1315  recA; RecA protein [KO:K03553]
lse_1480  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
lse_1448  ruvA; holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
lse_1447  ruvB; holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
lse_1791  recG; ATP-dependent DNA helicase [KO:K03655] [EC:3.6.4.12]
lse_1424  helicase, RecD/TraA family [KO:K03581] [EC:3.1.11.5]
lse_1489  dnaE; DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
lse_1236  polC; DNA polymerase III, alpha subunit, Gram-positive type [KO:K03763] [EC:2.7.7.7]
lse_0002  dnaN; DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
lse_2618  dnaX; DNA polymerase III, gamma and tau subunits [KO:K02343] [EC:2.7.7.7]
lse_1396  holA; holA [KO:K02340] [EC:2.7.7.7]
lse_0145  holB; DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
lse_1804  priA; primosomal protein N [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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