KEGG   PATHWAY: maf00523Help
Entry
maf00523                    Pathway                                

Name
Polyketide sugar unit biosynthesis - Mycobacterium africanum
Class
Metabolism; Metabolism of terpenoids and polyketides
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Polyketide sugar unit biosynthesis
maf00523

All organismsOrtholog table
Organism
Mycobacterium africanum [GN:maf]
Gene
rmlA; alpha-D-glucose-1-phosphate thymidylyltransferase [KO:K00973] [EC:2.7.7.24]
rmlB; dTDP-glucose 4,6-dehydratase RMLB [KO:K01710] [EC:4.2.1.46]
dTDP-glucose 4; K01710 dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] [KO:K01710] [EC:4.2.1.46]
rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [KO:K01790] [EC:5.1.3.13]
rmlD; dTDP-6-deoxy-L-lyxo-4-hexulose reductase [KO:K00067] [EC:1.1.1.133]
galE3; UDP-glucose 4-epimerase [KO:K17947] [EC:5.1.3.25]
Compound
C00103  
D-Glucose 1-phosphate
C00688  
dTDP-4-dehydro-beta-L-rhamnose
C00842  
dTDP-glucose
C03187  
dTDP-6-deoxy-beta-L-talose
C03319  
dTDP-L-rhamnose
C04268  
dTDP-4-amino-4,6-dideoxy-D-glucose
C07277  
dTDP-D-fucose
C11460  
dTDP-4-oxo-5-C-methyl-L-rhamnose
C11907  
dTDP-4-oxo-6-deoxy-D-glucose
C11908  
3,6-Dideoxy-3-oxo-dTDP-D-glucose
C11909  
dTDP-3-oxo-4,6-dideoxy-D-glucose
C11910  
dTDP-3-amino-3,4,6-trideoxy-D-glucose
C11911  
dTDP-D-desosamine
C11912  
dTDP-6-deoxy-D-allose
C11915  
dTDP-3-methyl-4-oxo-2,6-dideoxy-L-glucose
C11916  
dTDP-L-mycarose
C11918  
Maltol
C11919  
dTDP-L-megosamine
C11920  
dTDP-L-olivose
C11921  
dTDP-L-oleandrose
C11922  
dTDP-4-oxo-2,6-dideoxy-D-glucose
C11925  
dTDP-3-amino-3,6-dideoxy-D-glucose
C11926  
dTDP-4-oxo-6-deoxy-D-allose
C11927  
dTDP-4-oxo-2,6-dideoxy-L-mannose
C11928  
dTDP-4-oxo-2,6-dideoxy-D-allose
C11930  
dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose
C11931  
dTDP-2,6-dideoxy-L-glycero-hex-2-enos-4-ulose
C11932  
dTDP-2,6-dideoxy-L-erythro-hexos-3-ulose
C11933  
dTDP-D-mycaminose
C12481  
dTDP-5-dimethyl-L-lyxose
C18029  
dTDP-3-oxo-2,6-dideoxy-D-glucose
C18030  
dTDP-2,6-dideoxy-D-kanosamine
C18031  
dTDP-D-angolosamine
C18032  
dTDP-4-oxo-2,3,6-trideoxy-D-glucose
C18033  
dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose
C18034  
dTDP-D-forosamine
C18092  
dTDP-L-ristosamine
Reference
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (Part A--erythromycin biosynthesis).
  Journal
Nat Prod Rep 18:190-227 (2001)
Reference
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
Reference
  Authors
Wohlert S, Lomovskaya N, Kulowski K, Fonstein L, Occi JL, Gewain KM, MacNeil DJ, Hutchinson CR
  Title
Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans.
  Journal
Chem Biol 8:681-700 (2001)
Reference
  Authors
Aguirrezabalaga I, Olano C, Allende N, Rodriguez L, Brana AF, Mendez C, Salas JA
  Title
Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.
  Journal
Antimicrob Agents Chemother 44:1266-75 (2000)
Reference
  Authors
Bate N, Butler AR, Smith IP, Cundliffe E
  Title
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
  Journal
Microbiology 146 ( Pt 1):139-46 (2000)
Reference
  Authors
Amann S, Drager G, Rupprath C, Kirschning A, Elling L
  Title
(Chemo)enzymatic synthesis of dTDP-activated 2,6-dideoxysugars as building blocks of polyketide antibiotics.
  Journal
Carbohydr Res 335:23-32 (2001)
Reference
  Authors
Thibodeaux CJ, Melancon CE, Liu HW
  Title
Unusual sugar biosynthesis and natural product glycodiversification.
  Journal
Nature 446:1008-16 (2007)
Reference
  Authors
Volchegursky Y, Hu Z, Katz L, McDaniel R
  Title
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.
  Journal
Mol Microbiol 37:752-62 (2000)
Reference
(PMID:15609849 (Article in Russian))
  Authors
Mironov VA, Sergienko OV, Nastasiak IN, Danilenko VN.
  Title
Biogenesis and regulation of biosynthesis of erythromycins in Saccharopolyspora.
  Journal
Applied Biochemistry and Microbiology 40(6): 531-541 (2004)
KO pathway
 

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