| Entry |
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| Name |
Fatty acid elongation
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| Class |
Metabolism; Lipid metabolism
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| Pathway map |
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| Module |
| Fatty acid biosynthesis, elongation, mitochondria [PATH: map00062] | | Fatty acid biosynthesis, elongation, endoplasmic reticulum [PATH: map00062] |
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| Disease |
| Neuronal ceroid lipofuscinosis | | Hyperargininemia | | Progressive myoclonic epilepsy (PME) | | Stargardt disease (STGD) |
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| Reference |
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| Authors |
Seubert W, Lamberts I, Kramer R, Ohly B |
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| Title |
On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA. |
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| Journal |
Biochim Biophys Acta 164:498-517 (1968) |
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| Reference |
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| Authors |
El-Fakhri M, Middleton B |
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| Title |
The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria. |
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| Journal |
Biochim Biophys Acta 713:270-9 (1982) |
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| Reference |
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| Authors |
Cassagne C, Lessire R, Bessoule JJ, Moreau P, Creach A, Schneider F, Sturbois B |
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| Title |
Biosynthesis of very long chain fatty acids in higher plants. |
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| Journal |
Prog Lipid Res 33:55-69 (1994) |
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| Reference |
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| Authors |
Jakobsson A, Westerberg R, Jacobsson A. |
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| Title |
Fatty acid elongases in mammals: their regulation and roles in metabolism. |
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| Journal |
Prog Lipid Res 45:237-49 (2006) |
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| Reference |
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| Authors |
Blacklock BJ, Jaworski JG |
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| Title |
Substrate specificity of Arabidopsis 3-ketoacyl-CoA synthases. |
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| Journal |
Biochem Biophys Res Commun 346:583-90 (2006) |
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| Reference |
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| Authors |
Shepherd T, Wynne Griffiths D |
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| Title |
The effects of stress on plant cuticular waxes. |
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| Journal |
New Phytol 171:469-99 (2006) |
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| Reference |
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| Authors |
Riezman H |
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| Title |
The long and short of fatty acid synthesis. |
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| Journal |
Cell 130:587-8 (2007) |
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| Reference |
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| Authors |
Raffaele S, Leger A, Roby D |
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| Title |
Very long chain fatty acid and lipid signaling in the response of plants to pathogens. |
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| Journal |
Plant Signal Behav 4:94-9 (2009) |
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| KO pathway |
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