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Entry
map00600                    Pathway                                
Name
Sphingolipid metabolism
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
Sphingolipid metabolism
map00600

All organismsOrtholog table
Module
M00066  
Lactosylceramide biosynthesis [PATH:map00600]
M00067  
Cerebroside and sulfatide biosynthesis [PATH:map00600]
M00094  
Ceramide biosynthesis [PATH:map00600]
M00099  
Sphingosine biosynthesis [PATH:map00600]
M00100  
Sphingosine degradation [PATH:map00600]
Disease
H00125  
Fabry disease
H00126  
Gaucher disease
H00127  
Metachromatic leukodystrophy (MLD)
H00135  
Krabbe disease
H00137  
Niemann-Pick disease (NPD), including;
H00138  
Farber lipogranulomatosis
H00142  
Sialidosis
H00276  
Galactosialidosis
H00281  
GM1 gangliosidosis
H00810  
Progressive myoclonic epilepsy (PME)
Other DBs
Reference
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
Reference
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
Reference
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
Reference
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
KO pathway
 
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