| Entry |
|
|---|
| Name |
Porphyrin and chlorophyll metabolism
|
|---|
| Class |
Metabolism; Metabolism of cofactors and vitamins
 |
|---|
| Pathway map |
| Porphyrin and chlorophyll metabolism |
  |
|---|
| Module |
| Heme biosynthesis, glutamate => protoheme/siroheme [PATH: map00860] | | Cobalamin biosynthesis, cobinamide => cobalamin [PATH: map00860] |
|
|---|
| Disease |
| Erythropoietic porphyria (EP) | | Hepatic porphyria | | Hyperbilirubinemia | | Neurodegeneration with brain iron accumulation (NBIA) | | Anophthalmia and microphthalmia (A/M) | | Cataract |
|
|---|
| Other DBs |
|
|---|
| Reference |
|
|---|
| Authors |
Woodcock SC, Raux E, Levillayer F, Thermes C, Rambach A, Warren MJ. |
|---|
| Title |
Effect of mutations in the transmethylase and dehydrogenase/chelatase domains of sirohaem synthase (CysG) on sirohaem and cobalamin biosynthesis. |
|---|
| Journal |
Biochem J 330:121-9 (1998) |
|---|
| Reference |
|
|---|
| Authors |
Johansson P, Hederstedt L. |
|---|
| Title |
Organization of genes for tetrapyrrole biosynthesis in gram--positive bacteria. |
|---|
| Journal |
Microbiology 145:529-538 (1999) |
|---|
| Reference |
|
|---|
| Authors |
Maggio-Hall LA, Escalante-Semerena JC. |
|---|
| Title |
In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes. |
|---|
| Journal |
Proc Natl Acad Sci USA 96:11798-803 (1999) |
|---|
| Reference |
|
|---|
| Authors |
Roper JM, Raux E, Brindley AA, Schubert HL, Gharbia SE, Shah HN, Warren MJ. |
|---|
| Title |
The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway. |
|---|
| Journal |
J Biol Chem 275:40316-23 (2000) |
|---|
| Reference |
|
|---|
| Authors |
Scott AI, Roessner CA. |
|---|
| Title |
Biosynthesis of cobalamin (vitamin B(12)). |
|---|
| Journal |
Biochem Soc Trans 30:613-20 (2002) |
|---|
| Reference |
|
|---|
| Authors |
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC. |
|---|
| Title |
The biosynthesis of adenosylcobalamin (vitamin B12). |
|---|
| Journal |
Nat Prod Rep 19:390-412 (2002) |
|---|
| Reference |
|
|---|
| Authors |
Roessner CA, Huang KX, Warren MJ, Raux E, Scott AI. |
|---|
| Title |
Isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin B12) in Propionibacterium freudenreichii (P. shermanii). |
|---|
| Journal |
Microbiology 148:1845-53 (2002) |
|---|
| Reference |
|
|---|
| Authors |
Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC. |
|---|
| Title |
Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms. |
|---|
| Journal |
Plant Cell 13:965-78 (2001) |
|---|
| Reference |
|
|---|
| Authors |
Chew AG, Bryant DA |
|---|
| Title |
Chlorophyll biosynthesis in bacteria: the origins of structural and functional diversity. |
|---|
| Journal |
Annu Rev Microbiol 61:113-29 (2007) |
|---|
| Reference |
|
|---|
| Authors |
Frigaard NU, Chew AG, Li H, Maresca JA, Bryant DA |
|---|
| Title |
Chlorobium tepidum: insights into the structure, physiology, and metabolism of a green sulfur bacterium derived from the complete genome sequence. |
|---|
| Journal |
Photosynth Res 78:93-117 (2003) |
|---|
| Reference |
|
|---|
| Authors |
Deery E, Schroeder S, Lawrence AD, Taylor SL, Seyedarabi A, Waterman J, Wilson KS, Brown D, Geeves MA, Howard MJ, Pickersgill RW, Warren MJ |
|---|
| Title |
An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis. |
|---|
| Journal |
Nat Chem Biol 8:933-40 (2012) |
|---|
| KO pathway |
|
|---|
