| Entry |
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| Name |
Metabolism of xenobiotics by cytochrome P450
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| Class |
Metabolism; Xenobiotics biodegradation and metabolism
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| Pathway map |
| Metabolism of xenobiotics by cytochrome P450 |
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| Disease |
| Peters anomaly | | Cortisone reductase deficiency (CRD) | | Primary congenital glaucoma (PCG) |
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| Reference |
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| Authors |
Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C. |
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| Title |
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity. |
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| Journal |
Drug Metab Rev 34:791-820 (2002) |
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| Reference |
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| Authors |
Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ. |
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| Title |
Role of quinones in toxicology. |
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| Journal |
Chem Res Toxicol 13:135-60 (2000) |
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| Reference |
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| Authors |
Halladay JS, Sauer JM, Sipes IG. |
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| Title |
Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats. |
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| Journal |
Drug Metab Dispos 27:1456-65 (1999) |
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| Reference |
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| Authors |
Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR. |
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| Title |
Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy. |
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| Journal |
Chem Res Toxicol 12:831-9 (1999) |
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| Reference |
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| Authors |
Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG. |
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| Title |
Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes. |
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| Journal |
Drug Metab Dispos 32:1032-9 (2004) |
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| Reference |
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| Authors |
Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS. |
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| Title |
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1. |
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| Journal |
Drug Metab Dispos 33:1429-37 (2005) |
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| Reference |
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| Authors |
Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP. |
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| Title |
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat. |
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| Journal |
Drug Metab Dispos 25:508-15 (1997) |
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| Reference |
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| Authors |
Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR. |
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| Title |
Possible mechanism of liver necrosis caused by aromatic organic compounds. |
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| Journal |
Proc Natl Acad Sci U S A 68:160-4 (1971) |
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| Reference |
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| Authors |
Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P. |
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| Title |
Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH. |
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| Journal |
Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004) |
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| Reference |
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| Authors |
Omura T, Ishimura Y, Fujii Y (eds). |
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| Title |
[Molecular Biology of P450] (In Japanese) |
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| Journal |
Kodansya (2003) |
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| KO pathway |
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