| Entry |
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| Name |
Drug metabolism - other enzymes
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| Class |
Metabolism; Xenobiotics biodegradation and metabolism
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| Pathway map |
| Drug metabolism - other enzymes |
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| Disease |
| Dihydropyrimidine dehydrogenase deficiency | | Dihydropyrimidinase deficiency | | Beta-ureidopropionase deficiency | | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
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| Reference |
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| Authors |
Kato R, Kamatari T (eds). |
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| Title |
[Drug Metabolism] (In Japanese) |
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| Journal |
Tokyo Kagaku Dojin (2000) |
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| Reference |
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| Authors |
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR. |
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| Title |
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations. |
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| Journal |
Dig Liver Dis 37:282-97 (2005) |
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| Reference |
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| Authors |
Gearry RB, Barclay ML. |
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| Title |
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease. |
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| Journal |
J Gastroenterol Hepatol 20:1149-57 (2005) |
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| Reference |
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| Authors |
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG. |
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| Title |
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease. |
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| Journal |
Dig Liver Dis 39:182-6 (2007) |
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| Reference |
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| Authors |
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G. |
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| Title |
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes. |
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| Journal |
Anticancer Drugs 15:969-74 (2004) |
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| Reference |
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| Authors |
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H. |
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| Title |
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine. |
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| Journal |
Bioorg Med Chem 8:1697-706 (2000) |
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| Reference |
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| Authors |
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR. |
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| Title |
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy. |
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| Journal |
Clin Cancer Res 10:3863-70 (2004) |
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| Reference |
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| Authors |
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A. |
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| Title |
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11). |
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| Journal |
Clin Cancer Res 7:2182-94 (2001) |
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| Reference |
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| Authors |
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K. |
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| Title |
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients. |
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| Journal |
Biol Pharm Bull 24:544-9 (2001) |
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| KO pathway |
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