| Entry |
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| Name |
Steroid degradation
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| Class |
Metabolism; Xenobiotics biodegradation and metabolism
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| Pathway map |
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| Other DBs |
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| Reference |
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| Authors |
Ouellet H, Johnston JB, de Montellano PR |
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| Title |
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis. |
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| Journal |
Trends Microbiol 19:530-9 (2011) |
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| Reference |
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| Authors |
Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD |
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| Title |
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. |
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| Journal |
Proc Natl Acad Sci U S A 104:1947-52 (2007) |
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| Reference |
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| Authors |
Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS |
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| Title |
Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism. |
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| Journal |
J Biol Chem 286:43668-78 (2011) |
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| Reference |
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| Authors |
Driscoll MD, McLean KJ, Levy C, Mast N, Pikuleva IA, Lafite P, Rigby SE, Leys D, Munro AW |
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| Title |
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen. |
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| Journal |
J Biol Chem 285:38270-82 (2010) |
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| Reference |
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| Authors |
Johnston JB, Ouellet H, Ortiz de Montellano PR |
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| Title |
Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses. |
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| Journal |
J Biol Chem 285:36352-60 (2010) |
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| Reference |
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| Authors |
Yang X, Dubnau E, Smith I, Sampson NS |
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| Title |
Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. |
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| Journal |
Biochemistry 46:9058-67 (2007) |
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| Reference |
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| Authors |
Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD |
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| Title |
Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism. |
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| Journal |
J Biol Chem 285:434-43 (2010) |
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| Reference |
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| Authors |
Kreit J, Sampson NS |
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| Title |
Cholesterol oxidase: physiological functions. |
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| Journal |
FEBS J 276:6844-56 (2009) |
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| Reference |
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| Authors |
Horinouchi M, Hayashi T, Kudo T |
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| Title |
Steroid degradation in Comamonas testosteroni. |
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| Journal |
J Steroid Biochem Mol Biol 129:4-14 (2012) |
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| Reference |
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| Authors |
Horinouchi M, Kurita T, Hayashi T, Kudo T |
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| Title |
Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Delta4(5)-isomerase and 3alpha- and 3beta-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot. |
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| Journal |
J Steroid Biochem Mol Biol 122:253-63 (2010) |
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| KO pathway |
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