| Entry |
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| Name |
Biosynthesis of type II polyketide backbone
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| Class |
Metabolism; Metabolism of terpenoids and polyketides
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| Pathway map |
| Biosynthesis of type II polyketide backbone |
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| Reference |
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| Authors |
Rawlings BJ |
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| Title |
Biosynthesis of polyketides (other than actinomycete macrolides). |
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| Journal |
Nat Prod Rep 16:425-84 (1999) |
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| Reference |
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| Authors |
Hertweck C, Luzhetskyy A, Rebets Y, Bechthold A |
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| Title |
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. |
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| Journal |
Nat Prod Rep 24:162-90 (2007) |
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| Reference |
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| Authors |
Moore BS, Hertweck C |
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| Title |
Biosynthesis and attachment of novel bacterial polyketide synthase starter units. |
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| Journal |
Nat Prod Rep 19:70-99 (2002) |
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| Reference |
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| Authors |
Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM |
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| Title |
An antibiotic factory caught in action. |
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| Journal |
Nat Struct Mol Biol 11:888-93 (2004) |
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| Reference |
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| Authors |
Ridley CP, Lee HY, Khosla C |
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| Title |
Evolution of polyketide synthases in bacteria. |
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| Journal |
Proc Natl Acad Sci U S A 105:4595-600 (2008) |
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| Reference |
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| Authors |
Pickens LB, Tang Y |
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| Title |
Oxytetracycline biosynthesis. |
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| Journal |
J Biol Chem 285:27509-15 (2010) |
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| Reference |
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| Authors |
Petkovic H, Thamchaipenet A, Zhou LH, Hranueli D, Raspor P, Waterman PG, Hunter IS |
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| Title |
Disruption of an aromatase/cyclase from the oxytetracycline gene cluster of Streptomyces rimosus results in production of novel polyketides with shorter chain lengths. |
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| Journal |
J Biol Chem 274:32829-34 (1999) |
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| Reference |
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| Authors |
Zhou H, Li Y, Tang Y |
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| Title |
Cyclization of aromatic polyketides from bacteria and fungi. |
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| Journal |
Nat Prod Rep 27:839-68 (2010) |
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| Reference |
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| Authors |
Korman TP, Tan YH, Wong J, Luo R, Tsai SC |
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| Title |
Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase. |
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| Journal |
Biochemistry 47:1837-47 (2008) |
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| Reference |
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| Authors |
Kantola J, Blanco G, Hautala A, Kunnari T, Hakala J, Mendez C, Ylihonko K, Mantsala P, Salas J |
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| Title |
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline. |
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| Journal |
Chem Biol 4:751-5 (1997) |
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| Reference |
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| Authors |
Kunnari T, Ylihonko K, Hautala A, Klika KD, Mantsala P, Hakala J |
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| Title |
Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants. |
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| Journal |
Bioorg Med Chem Lett 9:2639-42 (1999) |
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| Reference |
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| Authors |
Tsai SC, Ames BD |
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| Title |
Structural enzymology of polyketide synthases. |
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| Journal |
Methods Enzymol 459:17-47 (2009) |
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| Reference |
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| Authors |
Korman TP, Hill JA, Vu TN, Tsai SC |
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| Title |
Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity. |
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| Journal |
Biochemistry 43:14529-38 (2004) |
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| Reference |
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| Authors |
Hadfield AT, Limpkin C, Teartasin W, Simpson TJ, Crosby J, Crump MP |
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| Title |
The crystal structure of the actIII actinorhodin polyketide reductase: proposed mechanism for ACP and polyketide binding. |
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| Journal |
Structure 12:1865-75 (2004) |
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| Reference |
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| Authors |
Kantola J, Kunnari T, Hautala A, Hakala J, Ylihonko K, Mantsala P |
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| Title |
Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp. |
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| Journal |
Microbiology 146 ( Pt 1):155-63 (2000) |
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| Reference |
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| Authors |
Bartel PL, Zhu CB, Lampel JS, Dosch DC, Connors NC, Strohl WR, Beale JM Jr, Floss HG |
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| Title |
Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions. |
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| Journal |
J Bacteriol 172:4816-26 (1990) |
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| Reference |
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| Authors |
Arthur CJ, Szafranska AE, Long J, Mills J, Cox RJ, Findlow SC, Simpson TJ, Crump MP, Crosby J |
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| Title |
The malonyl transferase activity of type II polyketide synthase acyl carrier proteins. |
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| Journal |
Chem Biol 13:587-96 (2006) |
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| Reference |
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| Authors |
Schneider G |
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| Title |
Enzymes in the biosynthesis of aromatic polyketide antibiotics. |
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| Journal |
Curr Opin Struct Biol 15:629-36 (2005) |
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| Reference |
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| Authors |
Summers RG, Wendt-Pienkowski E, Motamedi H, Hutchinson CR |
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| Title |
Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase. |
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| Journal |
J Bacteriol 174:1810-20 (1992) |
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| Reference |
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| Authors |
Ames BD, Korman TP, Zhang W, Smith P, Vu T, Tang Y, Tsai SC |
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| Title |
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. |
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| Journal |
Proc Natl Acad Sci U S A 105:5349-54 (2008) |
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| Reference |
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| Authors |
Lombo F, Menendez N, Salas JA, Mendez C |
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| Title |
The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives. |
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| Journal |
Appl Microbiol Biotechnol 73:1-14 (2006) |
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| Reference |
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| Authors |
Krohn K (ed). |
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| Title |
Anthracycline Chemistry and Biology I : Biological Occurence and Biosynthesis, Synthesis and Chemistry |
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| Journal |
Topics in Current Chemistry 282 (2008) |
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| KO pathway |
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