KEGG   PATHWAY: map04310Help
Entry
map04310                    Pathway                                

Name
Wnt signaling pathway
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Wnt signaling pathway
map04310

All organismsOrtholog table
Module
M00380  
SCF-BTRC complex [PATH:map04310]
M00677  
Wnt signaling [PATH:map04310]
Disease
H00078  
Frontotemporal lobar degeneration (FTLD)
H00409  
Type II diabetes mellitus
H00450  
Sclerosing bone dysplasias
H00451  
Osteoporosis-pseudoglioma syndrome (OPPG)
H00589  
Familial exudative vitreoretinopathy (FEVR)
H00598  
46,XX disorders of sex development (Disorders of gonadal development)
H00600  
46,XX disorders of sex development (Other)
H00607  
46,XY disorders of sex development (Disorders of gonadal development)
H00625  
Tooth agenesis
H00636  
Tetra-amelia
H00646  
Odontoonychodermal dysplasia
H00681  
Acne inversa
H00810  
Progressive myoclonic epilepsy (PME/ EPM)
H00857  
Oligodontia-colorectal cancer syndrome
H00881  
Li-Fraumeni syndrome
H00934  
Caudal duplication anomaly
H00947  
Pilomatricoma
H00949  
Focal dermal hypoplasia
H00979  
Caudal regression syndrome and Sirenomelia
H01007  
Choroid plexus papilloma
H01023  
Juvenile polyposis syndrome
H01025  
Familial adenomatous polyposis
H01037  
Vesicoureteral reflux
H01307  
Nonsyndromic congenital nail disorder (NDNC)
Other DBs
GO: 
Reference
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
Reference
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
Reference
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
Reference
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
Reference
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
Reference
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
Reference
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
Reference
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
Reference
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
Reference
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates  Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
KO pathway
 

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