KEGG PATHWAY: map04380

PATHWAY: map04380

Entry

map04380                    Pathway

Name

Osteoclast differentiation

Description

The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.

Class

Organismal Systems; Development and regeneration

Pathway map

map04380

Osteoclast differentiation

Other DBs

GO:

0030316

Reference

PMID:16313349

Authors

Takayanagi H, Sato K, Takaoka A, Taniguchi T

Title

Interplay between interferon and other cytokine systems in bone metabolism.

Journal

Immunol Rev 208:181-93 (2005)
DOI:10.1111/j.0105-2896.2005.00337.x

Reference

PMID:20392226

Authors

Takayanagi H

Title

New immune connections in osteoclast formation.

Journal

Ann N Y Acad Sci 1192:117-23 (2010)
DOI:10.1111/j.1749-6632.2009.05303.x

Reference

PMID:19585227

Authors

Nakashima T, Takayanagi H

Title

Osteoimmunology: crosstalk between the immune and bone systems.

Journal

J Clin Immunol 29:555-67 (2009)
DOI:10.1007/s10875-009-9316-6

Reference

PMID:18722561

Authors

Caetano-Lopes J, Canhao H, Fonseca JE

Title

Osteoimmunology--the hidden immune regulation of bone.

Journal

Autoimmun Rev 8:250-5 (2009)
DOI:10.1016/j.autrev.2008.07.038

Reference

PMID:18451259

Authors

Lorenzo J, Horowitz M, Choi Y

Title

Osteoimmunology: interactions of the bone and immune system.

Journal

Endocr Rev 29:403-40 (2008)
DOI:10.1210/er.2007-0038

Reference

PMID:17869613

Authors

David JP

Title

Osteoimmunology: a view from the bone.

Journal

Adv Immunol 95:149-65 (2007)
DOI:10.1016/S0065-2776(07)95005-1

Reference

PMID:16313342

Authors

Jimi E, Ghosh S

Title

Role of nuclear factor-kappaB in the immune system and bone.

Journal

Immunol Rev 208:80-7 (2005)
DOI:10.1111/j.0105-2896.2005.00329.x

Reference

PMID:12748652

Authors

Boyle WJ, Simonet WS, Lacey DL

Title

Osteoclast differentiation and activation.

Journal

Nature 423:337-42 (2003)
DOI:10.1038/nature01658

Reference

PMID:17633024

Authors

Darnay BG, Besse A, Poblenz AT, Lamothe B, Jacoby JJ

Title

TRAFs in RANK signaling.

Journal

Adv Exp Med Biol 597:152-9 (2007)
DOI:10.1007/978-0-387-70630-6_12

Reference

PMID:15122243

Authors

Baron R

Title

Arming the osteoclast.

Journal

Nat Med 10:458-60 (2004)
DOI:10.1038/nm0504-458

Reference

PMID:17380158

Authors

Takayanagi H

Title

Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.

Journal

Nat Rev Immunol 7:292-304 (2007)
DOI:10.1038/nri2062

Reference

PMID:20703218

Authors

Krum SA, Chang J, Miranda-Carboni G, Wang CY

Title

Novel functions for NFkappaB: inhibition of bone formation.

Journal

Nat Rev Rheumatol 6:607-11 (2010)
DOI:10.1038/nrrheum.2010.133

Reference

PMID:15817678

Authors

Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY

Title

A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation.

Journal

Blood 106:852-9 (2005)
DOI:10.1182/blood-2004-09-3662

Reference

PMID:18329366

Authors

Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H

Title

Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.

Journal

Cell 132:794-806 (2008)
DOI:10.1016/j.cell.2007.12.037

Reference

PMID:15546140

Authors

Takayanagi H, Kim S, Koga T, Taniguchi T

Title

Stat1-mediated cytoplasmic attenuation in osteoimmunology.

Journal

J Cell Biochem 94:232-40 (2005)
DOI:10.1002/jcb.20316

Reference

PMID:18382763

Authors

Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC

Title

Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.

Journal

J Clin Invest 118:1858-66 (2008)
DOI:10.1172/JCI34257

Reference

PMID:16184196

Authors

Bai S, Kitaura H, Zhao H, Chen J, Muller JM, Schule R, Darnay B, Novack DV, Ross FP, Teitelbaum SL

Title

FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.

Journal

J Clin Invest 115:2742-51 (2005)
DOI:10.1172/JCI24921

Reference

PMID:12110142

Authors

Takayanagi H, Kim S, Taniguchi T

Title

Signaling crosstalk between RANKL and interferons in osteoclast differentiation.

Journal

Arthritis Res 4 Suppl 3:S227-32 (2002)
DOI:10.1186/ar581

Related
pathway

map04010

MAPK signaling pathway

map04020

Calcium signaling pathway

map04064

NF-kappa B signaling pathway

map04151

PI3K-Akt signaling pathway

map04630

JAK-STAT signaling pathway

KO pathway

ko04380

All links

Chemical substance (3)   
   KEGG COMPOUND (3)   
Gene (99660)   
   KEGG ORTHOLOGY (104)   
   RefGene (99556)   
Literature (18)   
   PubMed (18)   
All databases (99681)   

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