KEGG   PATHWAY: map04630Help
Entry
map04630                    Pathway                                

Name
Jak-STAT signaling pathway
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Jak-STAT signaling pathway
map04630

All organismsOrtholog table
Module
M00684  
JAK-STAT signaling [PATH:map04630]
Disease
H00408  
Type I diabetes mellitus
H00539  
PTEN hamartoma tumor syndrome (PHTS)
H00931  
Growth hormone insensitivity with immunodeficiency
H00935  
Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
H01018  
Metachondromatosis
H01109  
Chronic mucocutaneous candidiasis (CMC)
H01122  
Pulmonary alveolar proteinosis (PAP)
H01217  
Primary localized cutaneous amyloidosis (PLCA)
H01227  
Inflammatory bowel disease
H01388  
Hyperprolactinemia
Other DBs
GO: 
Reference
  Authors
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW.
  Title
Signaling through the JAK/STAT pathway, recent advances and future challenges.
  Journal
Gene 285:1-24 (2002)
Reference
  Authors
Schindler CW.
  Title
Series introduction. JAK-STAT signaling in human disease.
  Journal
J Clin Invest 109:1133-7 (2002)
Reference
PMID:9716487
  Authors
Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L.
  Title
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.
  Journal
Biochem J 334 ( Pt 2):297-314 (1998)
Reference
  Authors
Luo C, Laaja P.
  Title
Inhibitors of JAKs/STATs and the kinases: a possible new cluster of drugs.
  Journal
Drug Discov Today 9:268-75 (2004)
Reference
  Authors
Hou SX, Zheng Z, Chen X, Perrimon N.
  Title
The Jak/STAT pathway in model organisms: emerging roles in cell movement.
  Journal
Dev Cell 3:765-78 (2002)
Reference
  Authors
Alexander WS, Hilton DJ.
  Title
The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response.
  Journal
Annu Rev Immunol 22:503-29 (2004)
Reference
  Authors
Kim H, Baumann H.
  Title
Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells.
  Journal
Mol Cell Biol 19:5326-38 (1999)
KO pathway
 

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