KEGG   PATHWAY: mbb03410
Entry
mbb03410                    Pathway                                
Name
Base excision repair - Mycobacterium tuberculosis variant bovis BCG Pasteur 1173P2
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
Pathway map
mbb03410  Base excision repair
mbb03410

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Mycobacterium tuberculosis variant bovis BCG Pasteur 1173P2 [GN:mbb]
Gene
BCG_3732c  nth; Probable endonuclease III nth [KO:K10773] [EC:3.2.2.- 4.2.99.18]
BCG_2997c  ung; Probable uracil-dna glycosylase ung [KO:K03648] [EC:3.2.2.27]
BCG_3654  mutY; Putative adenine glycosylase [KO:K03575] [EC:3.2.2.31]
BCG_1726  Possible 3-methyladenine DNA glycosylase [KO:K03652] [EC:3.2.2.21]
BCG_0998  Possible formamidopyrimidine-DNA glycosylase [KO:K10563] [EC:3.2.2.23 4.2.99.18]
BCG_2946c  fpg; Probable formamidopyrimidine-dna glycosylase fpg [KO:K10563] [EC:3.2.2.23 4.2.99.18]
BCG_3326  nei_1; Probable endonuclease VIII nei [KO:K05522] [EC:3.2.2.- 4.2.99.18]
BCG_3362  nei_2; Probable endonuclease VIII nei [KO:K05522] [EC:3.2.2.- 4.2.99.18]
BCG_2484c  Possible dna glycosylase [KO:K05522] [EC:3.2.2.- 4.2.99.18]
BCG_1378c  alkA; Putative ada regulatory protein alkA [KO:K13529] [EC:3.2.2.21]
BCG_1270  tagA; Probable DNA-3-methyladenine glycosylase i tagA [KO:K01246] [EC:3.2.2.20]
BCG_1317  Conserved hypothetical protein [KO:K21929] [EC:3.2.2.27]
BCG_0466c  xthA; Probable exodeoxyribonuclease III protein xthA [KO:K01142] [EC:3.1.11.2]
BCG_0719  end; Probable endonuclease IV end [KO:K01151] [EC:3.1.21.2]
BCG_1667  polA; DNA polymerase I polA [KO:K02335] [EC:2.7.7.7]
BCG_3036c  ligA; Probable dna ligase [nad dependent] ligA [KO:K01972] [EC:6.5.1.2]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease]
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   

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