KEGG   PATHWAY: mbo03440Help
Entry
mbo03440                    Pathway                                

Name
Homologous recombination - Mycobacterium bovis AF2122/97
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
mbo03440  Homologous recombination
mbo03440

Ortholog table
Module
mbo_M00260  DNA polymerase III complex, bacteria [PATH:mbo03440]
Other DBs
BSID: 13119
GO: 0000724
Organism
Mycobacterium bovis AF2122/97 [GN:mbo]
Gene
BQ2027_MB0055  ssb; single-strand binding protein ssb (helix-destabilizing protein) [KO:K03111]
BQ2027_MB2505C  hypothetical protein [KO:K03111]
BQ2027_MB0003  recF; DNA REPLICATION AND REPAIR PROTEIN RECF (SINGLE-STRAND DNA BINDING PROTEIN) [KO:K03629]
BQ2027_MB2383C  reco; possible dna repair protein reco [KO:K03584]
BQ2027_MB3742C  recR; probable recombination protein recr [KO:K06187]
BQ2027_MB2756C  recA; RECA PROTEIN (RECOMBINASE A) [CONTAINS: ENDONUCLEASE PI-MTUI (MTU RECA INTEIN)]. [KO:K03553]
BQ2027_MB1655  polA; probable dna polymerase i pola [KO:K02335] [EC:2.7.7.7]
BQ2027_MB2624C  ruvA; PROBABLE HOLLIDAY JUNCTION DNA HELICASE RUVA [KO:K03550] [EC:3.6.4.12]
BQ2027_MB2623C  ruvB; PROBABLE HOLLIDAY JUNCTION DNA HELICASE RUVB [KO:K03551] [EC:3.6.4.12]
BQ2027_MB2625C  ruvC; PROBABLE CROSSOVER JUNCTION ENDODEOXYRIBONUCLEASE RUVC (HOLLIDAY JUNCTION NUCLEASE) (HOLLIDAY JUNCTION RESOLVASE) [KO:K01159] [EC:3.1.22.4]
BQ2027_MB2998C  recG; PROBABLE ATP-DEPENDENT DNA HELICASE RECG [KO:K03655] [EC:3.6.4.12]
BQ2027_MB0647C  recBa; PROBABLE EXONUCLEASE V (BETA CHAIN) RECBA [FIRST PART] (EXODEOXYRIBONUCLEASE V BETA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE) [KO:K03582] [EC:3.1.11.5]
BQ2027_MB0646C  recBb; PROBABLE EXONUCLEASE V (BETA CHAIN) RECBB [SECOND PART] (EXODEOXYRIBONUCLEASE V BETA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE) [KO:K03582] [EC:3.1.11.5]
BQ2027_MB0648C  recC; PROBABLE EXONUCLEASE V (GAMMA CHAIN) RECC (EXODEOXYRIBONUCLEASE V GAMMA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE) [KO:K03583] [EC:3.1.11.5]
BQ2027_MB0645C  recD; PROBABLE EXONUCLEASE V (ALPHA CHAIN) RECD (EXODEOXYRIBONUCLEASE V ALPHA CHAIN) (EXODEOXYRIBONUCLEASE V POLYPEPTIDE) [KO:K03581] [EC:3.1.11.5]
BQ2027_MB1574  dnaE1; probable dna polymerase iii (alpha chain) dnae1 (dna nucleotidyltransferase) [KO:K02337] [EC:2.7.7.7]
BQ2027_MB0002  dnaN; DNA POLYMERASE III (BETA CHAIN) DNAN (DNA NUCLEOTIDYLTRANSFERASE) [KO:K02338] [EC:2.7.7.7]
BQ2027_MB3748C  dnaZX; DNA POLYMERASE III (SUBUNIT GAMMA/TAU) DNAZ/X [KO:K02343] [EC:2.7.7.7]
BQ2027_MB2436C  hypothetical protein [KO:K02340] [EC:2.7.7.7]
BQ2027_MB3668C  possible dna polymerase [KO:K02341] [EC:2.7.7.7]
BQ2027_MB3738C  dnaQ; probable dna polymerase iii (epsilon subunit) dnaq [KO:K02342] [EC:2.7.7.7]
BQ2027_MB2214  hypothetical protein [KO:K02342] [EC:2.7.7.7]
BQ2027_MB1437  priA; PUTATIVE PRIMOSOMAL PROTEIN N' PRIA (Replication factor Y) [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

DBGET integrated database retrieval system