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Entry
mcc00533                    Pathway                                

Name
Glycosaminoglycan biosynthesis - keratan sulfate - Macaca mulatta (rhesus monkey)
Description
Keratan sulfate (KS) is a glycosaminoglycan with the basic disaccharide unit of N-acetyllactosamine, Gal(b1-4)GlcNAc(b1-3), with sulfate esters at C-6 of GlcNAc and Gal residues. There are two types of KS distinguished by the protein linkage: type I for N-linked via the N-glycan core structure and type II for O-linked via the O-glycan core 2 structure.
Class
Metabolism; Glycan biosynthesis and metabolism
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Pathway map
Glycosaminoglycan biosynthesis - keratan sulfate
mcc00533

All organismsOrtholog table
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
708839  
FUT8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase) [KO:K00717] [EC:2.4.1.68]
703541  
B4GALT1; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 [KO:K07966] [EC:2.4.1.- 2.4.1.38 2.4.1.90 2.4.1.22]
704038  
B4GALT2; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 [KO:K07967] [EC:2.4.1.- 2.4.1.38 2.4.1.90 2.4.1.22]
719920  
B4GALT3; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 [KO:K07968] [EC:2.4.1.- 2.4.1.38 2.4.1.90]
693396  
B3GNT2; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 [KO:K00741] [EC:2.4.1.149]
714270  
B3GNT1; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 [KO:K00741] [EC:2.4.1.149]
711570  
CHST6; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 [KO:K09671] [EC:2.8.2.-]
711983  
B4GALT4; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 [KO:K07969] [EC:2.4.1.- 2.4.1.275 2.4.1.90]
716017  
UDP-GlcNAc:betaGal beta-1; K09664 beta-1,3-N-acetylglucosaminyltransferase 7 [EC:2.4.1.-] [KO:K09664] [EC:2.4.1.-]
715176  
CHST1; carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 [KO:K01022] [EC:2.8.2.21]
703599  
ST3GAL3; ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [KO:K00781] [EC:2.4.99.6]
713994  
CHST2; carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 [KO:K04745] [EC:2.8.2.-]
708116  
CHST4; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 [KO:K04746] [EC:2.8.2.-]
698004  
ST3GAL1; ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [KO:K00780] [EC:2.4.99.4]
709319  
ST3GAL2; ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [KO:K03368] [EC:2.4.99.4]
Reference
  Authors
Funderburgh JL.
  Title
Keratan sulfate: structure, biosynthesis, and function.
  Journal
Glycobiology 10:951-958 (2000)
Reference
  Authors
Seko A, Yamashita K.
  Title
beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans.
  Journal
FEBS Lett 556:216-20 (2004)
Reference
  Authors
Seko A, Dohmae N, Takio K, Yamashita K.
  Title
Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.
  Journal
J Biol Chem 278:9150-8 (2003)
KO pathway
 

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