KEGG PATHWAY: mcc04360

PATHWAY: mcc04360

Entry

mcc04360 Pathway

Name

Axon guidance - Macaca mulatta (rhesus monkey)

Description

Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.

Class

Organismal Systems; Development

Pathway map

mcc04360

Axon guidance

Other DBs

BSID:

86735

GO:

0007411

Organism

Macaca mulatta (rhesus monkey) [GN:mcc]

Gene

717645	NTN1; netrin 1 [KO:K06843]
693352	DCC; deleted in colorectal carcinoma [KO:K06765]
695596	ras-related C3 botulinum toxin substrate 1-like; K04392 Ras-related C3 botulinum toxin substrate 1 [KO:K04392]
717755	40S ribosomal protein S0-like; K04392 Ras-related C3 botulinum toxin substrate 1 [KO:K04392]
696709	RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
719305	ras-related C3 botulinum toxin substrate 3-like; K07861 Ras-related C3 botulinum toxin substrate 3 [KO:K07861]
698641	ABLIM1; actin binding LIM protein 1 [KO:K07520]
709180	ABLIM3; actin binding LIM protein family, member 3 [KO:K07520]
722653	ABLIM2; actin binding LIM protein family, member 2 [KO:K07520]
706955	PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
708233	PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
709773	PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
574258	PPP3R2; protein phosphatase 3, regulatory subunit B, beta [KO:K06268]
701087	CHP2; calcineurin-like EF hand protein 2 [KO:K06268]
705482	CHP1; calcineurin-like EF hand protein 1 [KO:K06268]
100428682	calcineurin subunit B type 1-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
698089	NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [KO:K04446]
705518	NFAT5; nuclear factor of activated T-cells 5, tonicity-responsive [KO:K04446]
710601	NFATC2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [KO:K04446]
702390	NFATC3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 [KO:K04446]
714785	nuclear factor of activated T-cells; K04446 nuclear factor of activated T-cells, cytoplasmic [KO:K04446]
706455	transforming protein RhoA-like; K04513 Ras homolog gene family, member A [KO:K04513]
698223	ROCK1; Rho-associated, coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
708444	ROCK2; Rho-associated, coiled-coil containing protein kinase 2 [KO:K04514] [EC:2.7.11.1]
697619	UNC5D; unc-5 homolog D (C. elegans) [KO:K07521]
715786	UNC5B; unc-5 homolog B (C. elegans) [KO:K07521]
705591	UNC5C; unc-5 homolog C (C. elegans) [KO:K07521]
696990	NTN3; netrin 3 [KO:K06844]
712628	NTN4; netrin 4 [KO:K06845]
694410	NTNG1; netrin G1 [KO:K07522]
715127	NTNG2; netrin G2 [KO:K16359]
716620	LRRC4C; leucine rich repeat containing 4C [KO:K07523]
698610	LRRC4; leucine rich repeat containing 4 [KO:K16351]
717399	ephrin-A1-like; K05462 ephrin-A [KO:K05462]
717373	EFNA3; ephrin-A3 [KO:K05462]
704351	EFNA5; ephrin-A5 [KO:K05462]
717315	ephrin-A4-like; K05462 ephrin-A [KO:K05462]
721231	uncharacterized LOC721231; K05462 ephrin-A [KO:K05462]
574214	FYN; FYN oncogene related to SRC, FGR, YES [KO:K05703] [EC:2.7.10.2]
716257	EFNB3; ephrin-B3 [KO:K05463]
711288	EFNB2; ephrin-B2 [KO:K05463]
694149	EFNB1; ephrin-B1 [KO:K05463]
700634	PTK2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
709612	regulator of G-protein signaling 3-like; K07524 regulator of G-protein signalling 3 [KO:K07524]
706295	EPHA1; EPH receptor A1 [KO:K05102] [EC:2.7.10.1]
692343	EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
694583	EPHA3; EPH receptor A3 [KO:K05104] [EC:2.7.10.1]
704857	EPHA4; EPH receptor A4 [KO:K05105] [EC:2.7.10.1]
712074	EPHA5; EPH receptor A5 [KO:K05106] [EC:2.7.10.1]
696491	EPHA6; EPH receptor A6 [KO:K05107] [EC:2.7.10.1]
707295	ephrin type-A receptor 7-like; K05108 EphA7 [EC:2.7.10.1] [KO:K05108] [EC:2.7.10.1]
708378	EPHA8; EPH receptor A8 [KO:K05109] [EC:2.7.10.1]
717211	EPHB1; EPH receptor B1 [KO:K05110] [EC:2.7.10.1]
718570	EPHB2; EPH receptor B2 [KO:K05111] [EC:2.7.10.1]
701811	EPHB3; EPH receptor B3 [KO:K05112] [EC:2.7.10.1]
719320	EPHB4; EPH receptor B4 [KO:K05113] [EC:2.7.10.1]
704886	EPHB6; EPH receptor B6 [KO:K05114] [EC:2.7.10.1]
722449	ABL1; c-abl oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
713917	ephexin-1-like; K07525 neuronal guanine nucleotide exchange factor [KO:K07525]
707637	CDC42; cell division cycle 42 (GTP binding protein, 25kDa) [KO:K04393]
698585	PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 [KO:K04409] [EC:2.7.11.1]
710314	PAK2; p21 protein (Cdc42/Rac)-activated kinase 2 [KO:K04410] [EC:2.7.11.1]
706217	PAK3; p21 protein (Cdc42/Rac)-activated kinase 3 [KO:K05733] [EC:2.7.11.1]
696676	PAK4; p21 protein (Cdc42/Rac)-activated kinase 4 [KO:K05734] [EC:2.7.11.1]
701589	PAK6; p21 protein (Cdc42/Rac)-activated kinase 6 [KO:K05735] [EC:2.7.11.1]
719458	PAK7; p21 protein (Cdc42/Rac)-activated kinase 7 [KO:K05736] [EC:2.7.11.1]
694085	RASA1; RAS p21 protein activator (GTPase activating protein) 1 [KO:K04352]
698830	HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog [KO:K02833]
707977	KRAS; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
709089	NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
698569	MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
708938	MAPK3; mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
707329	CXCR4; chemokine (C-X-C motif) receptor 4 [KO:K04189]
699310	GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 [KO:K04630]
703780	GNAI2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [KO:K04630]
708940	guanine nucleotide-binding protein G(i) subunit alpha-1-like; K04630 guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
705901	SLIT1; slit homolog 1 (Drosophila) [KO:K06838]
715470	SLIT2; slit homolog 2 protein-like [KO:K06839]
703950	slit homolog 3 protein-like; K06850 slit 3 [KO:K06850]
722879	ROBO1; roundabout, axon guidance receptor, homolog 1 (Drosophila) [KO:K06753]
719197	roundabout homolog 2-like; K06754 roundabout, axon guidance receptor 2 [KO:K06754]
716274	ROBO3; roundabout, axon guidance receptor, homolog 3 (Drosophila) [KO:K06755]
717169	SRGAP1; SLIT-ROBO Rho GTPase activating protein 1 [KO:K07526]
695724	SRGAP2; SLIT-ROBO Rho GTPase activating protein 2 [KO:K07526]
701809	SRGAP1; SLIT-ROBO Rho GTPase-activating protein 3-like [KO:K07526]
708263	semaphorin-3A-like; K06840 semaphorin 3 [KO:K06840]
707146	SEMA3D; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D [KO:K06840]
703553	SEMA3B; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B [KO:K06840]
708633	SEMA3C; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C [KO:K06840]
703995	SEMA3F; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F [KO:K06840]
697162	SEMA3G; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G [KO:K06840]
707673	SEMA3E; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E [KO:K06840]
716805	PLXNA1; plexin A1 [KO:K06820]
713800	PLXNA2; plexin A2 [KO:K06820]
700399	PLXNA3; plexin A3 [KO:K06820]
705098	PLXNA4; plexin A4 [KO:K06820]
697755	NRP1; neuropilin 1 [KO:K06724]
697504	L1CAM; L1 cell adhesion molecule [KO:K06550]
713114	GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
714445	CDK5; cyclin-dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
715764	FES; feline sarcoma oncogene [KO:K07527] [EC:2.7.10.2]
712368	DPYSL2; dihydropyrimidinase-like 2 [KO:K07528]
699648	DPYSL5; dihydropyrimidinase-like 5 [KO:K07529]
699494	LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
716614	LIMK2; LIM domain kinase 2-like [KO:K05744] [EC:2.7.11.1]
693875	CFL2; cofilin 2 (muscle) [KO:K05765]
721882	CFL1; cofilin 1 (non-muscle) [KO:K05765]
712969	rho-related GTP-binding protein RhoD-like; K07530 Ras homolog gene family, member D [KO:K07530]
710161	rho-related GTP-binding protein Rho6-like; K07531 Rho family GTPase 1 [KO:K07531]
697697	SEMA4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D [KO:K06521]
710297	semaphorin-4F-like; K06521 semaphorin 4 [KO:K06521]
710879	SEMA4G; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G [KO:K06521]
708168	SEMA4B; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B [KO:K06521]
707024	SEMA4C; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C [KO:K06521]
718191	SEMA4A; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A [KO:K06521]
696019	SEMA5A; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A [KO:K06841]
715682	SEMA5B; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B [KO:K06841]
709464	SEMA6C; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C [KO:K06842]
713885	SEMA6D; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D [KO:K06842]
719044	semaphorin-6B-like; K06842 semaphorin 6 [KO:K06842]
694125	semaphorin-6B-like; K06842 semaphorin 6 [KO:K06842]
697481	SEMA6A; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A [KO:K06842]
696903	PLXNB3; plexin B3 [KO:K06821]
720646	PLXNB2; plexin B2 [KO:K06821]
709802	PLXNB1; plexin B1 [KO:K06821]
704562	MET; met proto-oncogene (hepatocyte growth factor receptor) [KO:K05099] [EC:2.7.10.1]
712096	ARHGEF12; Rho guanine nucleotide exchange factor (GEF) 12 [KO:K07532]
702185	SEMA7A; semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) [KO:K06529]
574312	ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
711320	PLXNC1; plexin C1 [KO:K06572]

Compound

C00076

Calcium cation

Reference

PMID:14682358

Authors

Guan KL, Rao Y.

Title

Signalling mechanisms mediating neuronal responses to guidance cues.

Journal

Nat Rev Neurosci 4:941-56 (2003)

Reference

PMID:15630019

Authors

Govek EE, Newey SE, Van Aelst L.

Title

The role of the Rho GTPases in neuronal development.

Journal

Genes Dev 19:1-49 (2005)

Reference

PMID:12677003

Authors

Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.

Title

Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.

Journal

Annu Rev Neurosci 26:509-63 (2003)

Reference

PMID:15818466

Authors

Negishi M, Oinuma I, Katoh H.

Title

Plexins: axon guidance and signal transduction.

Journal

Cell Mol Life Sci 62:1363-71 (2005)

Reference

PMID:15363605

Authors

Huot J.

Title

Ephrin signaling in axon guidance.

Journal

Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)

Reference

PMID:11891122

Authors

Patel BN, Van Vactor DL.

Title

Axon guidance: the cytoplasmic tail.

Journal

Curr Opin Cell Biol 14:221-9 (2002)

Reference

PMID:11687826

Authors

Yu TW, Bargmann CI.

Title

Dynamic regulation of axon guidance.

Journal

Nat Neurosci 4 Suppl:1169-76 (2001)

Reference

PMID:12471249

Authors

Dickson BJ.

Title

Molecular mechanisms of axon guidance.

Journal

Science 298:1959-64 (2002)

Reference

PMID:15960985

Authors

Barallobre MJ, Pascual M, Del Rio JA, Soriano E.

Title

The Netrin family of guidance factors: emphasis on Netrin-1 signalling.

Journal

Brain Res Brain Res Rev 49:22-47 (2005)

Reference

PMID:15084255

Authors

Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.

Title

The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.

Journal

Cell 117:157-69 (2004)

KO pathway

ko04360

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (130)   
   KEGG GENES (130)   
All databases (132)   

Download RDF

DBGET integrated database retrieval system