KEGG PATHWAY: mcc04622

PATHWAY: mcc04622

Entry

mcc04622 Pathway

Name

RIG-I-like receptor signaling pathway - Macaca mulatta (rhesus monkey)

Description

Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.

Class

Organismal Systems; Immune system

Pathway map

mcc04622

RIG-I-like receptor signaling pathway

Organism

Macaca mulatta (rhesus monkey) [GN:mcc]

Gene

704638	DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [KO:K12646] [EC:3.6.3.14]
702024	IFIH1; interferon induced with helicase C domain 1 [KO:K12647] [EC:3.6.4.13]
717616	MAVS; mitochondrial antiviral signaling protein [KO:K12648]
709116	DHX58; DEXH (Asp-Glu-X-His) box polypeptide 58 [KO:K12649] [EC:3.6.3.14]
693961	TRAF3; TNF receptor-associated factor 3 [KO:K03174]
700942	TANK; TRAF family member-associated NFKB activator [KO:K12650]
705275	AZI2; 5-azacytidine induced 2 [KO:K12651]
693913	TBKBP1; TBK1 binding protein 1 [KO:K12652]
701237	IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
717427	TBK1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
695607	IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon [KO:K07211] [EC:2.7.11.10]
718970	IRF3; interferon regulatory factor 3 [KO:K05411]
699578	IRF7; interferon regulatory factor 7 [KO:K09447]
709948	IFNA2; interferon, alpha 2 [KO:K05414]
709755	IFNA8; interferon, alpha 8 [KO:K05414]
710707	interferon alpha-6-like; K05414 interferon alpha [KO:K05414]
710751	interferon alpha-17-like; K05414 interferon alpha [KO:K05414]
694631	interferon alpha-1/13-like; K05414 interferon alpha [KO:K05414]
710487	IFNA14; interferon, alpha 14 [KO:K05414]
710528	interferon alpha-1/13-like; K05414 interferon alpha [KO:K05414]
710568	interferon alpha-4-like; K05414 interferon alpha [KO:K05414]
710654	IFNA10; interferon, alpha 10 [KO:K05414]
711252	interferon alpha-21-like; K05414 interferon alpha [KO:K05414]
709559	IFNA13; interferon, alpha 13 [KO:K05414]
711414	IFNB1; interferon, beta 1, fibroblast [KO:K05415]
711329	IFNW1; interferon, omega 1 [KO:K05440]
707234	IFNK; interferon, kappa [KO:K05441]
698160	tumor necrosis factor receptor type 1-associated DEATH domain protein-like; K03171 tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
708606	protein FADD-like; K02373 FAS-associated death domain protein [KO:K02373]
708013	RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
702781	CASP8; caspase 8, apoptosis-related cysteine peptidase [KO:K04398] [EC:3.4.22.61]
701295	CASP10; caspase 10, apoptosis-related cysteine peptidase [KO:K04400] [EC:3.4.22.63]
709511	CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
704683	IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
694844	NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta [KO:K02581]
695335	NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO:K04734]
710324	NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
715919	RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
708391	TRAF2; TNF receptor-associated factor 2 [KO:K03173]
703101	MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
716907	TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
710979	MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [KO:K04416] [EC:2.7.11.25]
699736	MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
711115	MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
715745	MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
715794	MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
718976	mitogen-activated protein kinase 14-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
719085	mitogen-activated protein kinase 13-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
613028	IL8; interleukin 8 [KO:K10030]
715467	TNF; tumor necrosis factor [KO:K03156]
703205	IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [KO:K05406]
694747	IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [KO:K05425]
574243	CXCL10; chemokine (C-X-C motif) ligand 10 [KO:K12671]
712588	e3 ubiquitin/ISG15 ligase TRIM25-like; K10652 tripartite motif-containing protein 25 [KO:K10652]
695652	CYLD; cylindromatosis (turban tumor syndrome) [KO:K08601] [EC:3.1.2.15]
706726	RNF125; ring finger protein 125, E3 ubiquitin protein ligase [KO:K12170] [EC:6.3.2.19]
700141	ISG15; ISG15 ubiquitin-like modifier [KO:K12159]
696874	ATG5; autophagy related 5 [KO:K08339]
703981	NLRX1; NLR family member X1 [KO:K12653]
694353	TMEM173; transmembrane protein 173 [KO:K12654]
708999	SIKE1; suppressor of IKBKE 1 [KO:K12656]
706891	DDX3X; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked [KO:K11594] [EC:3.6.4.13]
100270694	DDX3Y; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked [KO:K11594] [EC:3.6.4.13]
711095	PIN1; peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
694117	DAK; bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)-like [KO:K00863] [EC:2.7.1.29]

Reference

PMID:15208624

Authors

Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T

Title

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.

Journal

Nat Immunol 5:730-7 (2004)

Reference

PMID:18272355

Authors

Takeuchi O, Akira S

Title

MDA5/RIG-I and virus recognition.

Journal

Curr Opin Immunol 20:17-22 (2008)

Reference

PMID:19120475

Authors

Yoneyama M, Fujita T

Title

RNA recognition and signal transduction by RIG-I-like receptors.

Journal

Immunol Rev 227:54-65 (2009)

Reference

PMID:19539500

Authors

Nakhaei P, Genin P, Civas A, Hiscott J

Title

RIG-I-like receptors: Sensing and responding to RNA virus infection.

Journal

Semin Immunol (2009)

Reference

PMID:18549796

Authors

Moore CB, Ting JP

Title

Regulation of mitochondrial antiviral signaling pathways.

Journal

Immunity 28:735-9 (2008)

Reference

PMID:19615405

Authors

Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB

Title

Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.

Journal

Pharmacol Ther 124:219-34 (2009)

Reference

PMID:19120476

Authors

Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G

Title

Approaching the RNA ligand for RIG-I?

Journal

Immunol Rev 227:66-74 (2009)

Reference

PMID:18591413

Authors

Saito T, Gale M Jr

Title

Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.

Journal

J Exp Med 205:1523-7 (2008)

Reference

PMID:19076341

Authors

Kawai T, Akira S

Title

Toll-like receptor and RIG-I-like receptor signaling.

Journal

Ann N Y Acad Sci 1143:1-20 (2008)

Reference

PMID:18439848

Authors

Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J

Title

TRADD protein is an essential component of the RIG-like helicase antiviral pathway.

Journal

Immunity 28:651-61 (2008)

Reference

PMID:18984593

Authors

Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T

Title

TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.

Journal

J Biol Chem 283:36211-20 (2008)

Reference

PMID:19224920

Authors

Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR

Title

RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.

Journal

J Biol Chem 284:10774-82 (2009)

KO pathway

ko04622

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (65)   
   KEGG GENES (65)   
All databases (67)   

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