KEGG   PATHWAY: mcc04622Help
Entry
mcc04622                    Pathway                                

Name
RIG-I-like receptor signaling pathway - Macaca mulatta (rhesus monkey)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
RIG-I-like receptor signaling pathway
mcc04622

All organismsOrtholog table
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
704638  
DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [KO:K12646] [EC:3.6.3.14]
702024  
IFIH1; interferon induced with helicase C domain 1 [KO:K12647] [EC:3.6.4.13]
717616  
MAVS; mitochondrial antiviral signaling protein [KO:K12648]
709116  
DHX58; DEXH (Asp-Glu-X-His) box polypeptide 58 [KO:K12649] [EC:3.6.3.14]
693961  
TRAF3; TNF receptor-associated factor 3 [KO:K03174]
700942  
TANK; TRAF family member-associated NFKB activator [KO:K12650]
705275  
AZI2; 5-azacytidine induced 2 [KO:K12651]
693913  
TBKBP1; TBK1 binding protein 1 [KO:K12652]
701237  
IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
717427  
TBK1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
695607  
IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon [KO:K07211] [EC:2.7.11.10]
718970  
IRF3; interferon regulatory factor 3 [KO:K05411]
699578  
IRF7; interferon regulatory factor 7 [KO:K09447]
709948  
IFNA2; interferon, alpha 2 [KO:K05414]
709755  
IFNA8; interferon, alpha 8 [KO:K05414]
710707  
interferon alpha-6-like; K05414 interferon alpha [KO:K05414]
710751  
interferon alpha-17-like; K05414 interferon alpha [KO:K05414]
694631  
interferon alpha-1/13-like; K05414 interferon alpha [KO:K05414]
710487  
IFNA14; interferon, alpha 14 [KO:K05414]
710528  
interferon alpha-1/13-like; K05414 interferon alpha [KO:K05414]
710568  
interferon alpha-4-like; K05414 interferon alpha [KO:K05414]
710654  
IFNA10; interferon, alpha 10 [KO:K05414]
711252  
interferon alpha-21-like; K05414 interferon alpha [KO:K05414]
709559  
IFNA13; interferon, alpha 13 [KO:K05414]
711088  
interferon alpha-17-like; K05414 interferon alpha [KO:K05414]
711414  
IFNB1; interferon, beta 1, fibroblast [KO:K05415]
711329  
IFNW1; interferon, omega 1 [KO:K05440]
707234  
IFNK; interferon, kappa [KO:K05441]
698160  
tumor necrosis factor receptor type 1-associated DEATH domain protein-like; K03171 tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
708606  
protein FADD-like; K02373 FAS-associated death domain protein [KO:K02373]
708013  
RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
702781  
CASP8; caspase 8, apoptosis-related cysteine peptidase [KO:K04398] [EC:3.4.22.61]
701295  
CASP10; caspase 10, apoptosis-related cysteine peptidase [KO:K04400] [EC:3.4.22.63]
709511  
CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
704683  
IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
694844  
NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta [KO:K02581]
695335  
NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO:K04734]
710324  
NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
715919  
RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
708391  
TRAF2; TNF receptor-associated factor 2 [KO:K03173]
703101  
MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
716907  
TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
710979  
MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [KO:K04416] [EC:2.7.11.25]
699736  
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
711115  
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
715745  
MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
715794  
MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
718976  
mitogen-activated protein kinase 14-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
719085  
mitogen-activated protein kinase 13-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
613028  
CXCL8; interleukin 8 [KO:K10030]
715467  
TNF; tumor necrosis factor [KO:K03156]
703205  
IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [KO:K05406]
694747  
IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [KO:K05425]
574243  
CXCL10; chemokine (C-X-C motif) ligand 10 [KO:K12671]
712588  
e3 ubiquitin/ISG15 ligase TRIM25-like; K10652 tripartite motif-containing protein 25 [EC:6.3.2.19] [KO:K10652] [EC:6.3.2.19]
695652  
CYLD; cylindromatosis (turban tumor syndrome) [KO:K08601] [EC:3.1.2.15]
706726  
RNF125; ring finger protein 125, E3 ubiquitin protein ligase [KO:K12170] [EC:6.3.2.19]
700141  
ISG15; ISG15 ubiquitin-like modifier [KO:K12159]
696874  
ATG5; autophagy related 5 [KO:K08339]
703981  
NLRX1; NLR family member X1 [KO:K12653]
694353  
TMEM173; transmembrane protein 173 [KO:K12654]
708999  
SIKE1; suppressor of IKBKE 1 [KO:K12656]
706891  
DDX3X; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked [KO:K11594] [EC:3.6.4.13]
711095  
PIN1; peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
694117  
DAK; bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)-like [KO:K00863] [EC:2.7.1.29]
Reference
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
Reference
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
Reference
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
Reference
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
Reference
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
Reference
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
Reference
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
Reference
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
Reference
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
Reference
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
Reference
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
Reference
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
KO pathway
 

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