KEGG   PATHWAY: mcc05012Help
Entry
mcc05012                    Pathway                                

Name
Parkinson's disease - Macaca mulatta (rhesus monkey)
Description
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations in alpha-synuclein, UCHL1 (a ubiquitin carboxy-terminal hydrolase L1), parkin, DJ1 (a parkin-associated protein involved with oxidative stress), and PINK1 (a putative serine threonine kinase) are known to cause early-onset PD. Mutations or altered expression of these proteins contributes to the damage and subsequent loss of DA neurons through common mechanisms that result in proteasome dysfunction, mitochondrial impairment, and oxidative stress. The demise of DA neurons located in the SNc leads to a drop in the dopaminergic input to the striatum. This results in a reduced activation of the direct pathway and in a disinhibition of the indirect pathway, which is associated with the elevation of adenosine A2A receptor transmission. Such unbalanced activity of the striatal output pathway is at the basis of the motor impairment observed in PD.
Class
Human Diseases; Neurodegenerative diseases
BRITE hierarchy
Pathway map
Parkinson's disease
mcc05012

All organismsOrtholog table
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
707865  
ADORA2A; adenosine A2a receptor [KO:K04266]
694181  
DRD2; dopamine receptor D2 [KO:K04145]
699310  
GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 [KO:K04630]
703780  
GNAI2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [KO:K04630]
708940  
guanine nucleotide-binding protein G(i) subunit alpha-1-like; K04630 guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
715897  
ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
709728  
PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
718632  
PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
697796  
DRD1; dopamine receptor D1 [KO:K04144]
706324  
UBA1; ubiquitin-like modifier activating enzyme 1 [KO:K03178] [EC:6.3.2.19]
704875  
UBA7; ubiquitin-like modifier activating enzyme 7 [KO:K10698] [EC:6.3.2.19]
696110  
UBB; ubiquitin B [KO:K04551]
699895  
UBE2L3; ubiquitin-conjugating enzyme E2L 3 [KO:K04552] [EC:6.3.2.19]
697675  
UBE2L3; ubiquitin-conjugating enzyme E2L 3 [KO:K04552] [EC:6.3.2.19]
712771  
ubiquitin-conjugating enzyme E2 L3-like; K04552 ubiquitin-conjugating enzyme E2 L3 [EC:6.3.2.19] [KO:K04552] [EC:6.3.2.19]
709150  
ubiquitin-conjugating enzyme E2 L3-like; K04552 ubiquitin-conjugating enzyme E2 L3 [EC:6.3.2.19] [KO:K04552] [EC:6.3.2.19]
700798  
UBE2J2; ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:6.3.2.19]
701100  
UBE2J1; ubiquitin-conjugating enzyme E2, J1 [KO:K10578] [EC:6.3.2.19]
710862  
UBE2G2; ubiquitin-conjugating enzyme E2G 2 [KO:K04555] [EC:6.3.2.19]
721528  
ubiquitin-conjugating enzyme E2 G1-like; K10575 ubiquitin-conjugating enzyme E2 G1 [EC:6.3.2.19] [KO:K10575] [EC:6.3.2.19]
710899  
e3 ubiquitin-protein ligase parkin-like; K04556 parkin [EC:6.3.2.19] [KO:K04556] [EC:6.3.2.19]
711610  
e3 ubiquitin-protein ligase parkin-like; K04556 parkin [EC:6.3.2.19] [KO:K04556] [EC:6.3.2.19]
706985  
SNCA; alpha-synuclein-like [KO:K04528]
696628  
GPR37; G protein-coupled receptor 37 (endothelin receptor type B-like) [KO:K04243]
712041  
SEPT5; septin 5 [KO:K04557]
700372  
SNCAIP; synuclein, alpha interacting protein [KO:K04558]
701579  
ubiquitin carboxyl-terminal hydrolase isozyme L1-like; K05611 ubiquitin carboxyl-terminal hydrolase L1 [EC:3.4.19.12] [KO:K05611] [EC:3.4.19.12]
721137  
TH; tyrosine hydroxylase [KO:K00501] [EC:1.14.16.2]
574143  
SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 [KO:K05036]
701133  
SLC18A2; solute carrier family 18 (vesicular monoamine), member 2 [KO:K08155]
705489  
SLC18A1; solute carrier family 18 (vesicular monoamine), member 1 [KO:K08155]
ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:1.6.5.3]
718685  
MT-ND1; mitochondrially encoded NADH dehydrogenase 1 [KO:K03878] [EC:1.6.5.3]
ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:1.6.5.3]
ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:1.6.5.3]
ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:1.6.5.3]
ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:1.6.5.3]
ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:1.6.5.3]
ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:1.6.5.3]
711412  
NADH dehydrogenase [ubiquinone] flavoprotein 1; K03942 NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:1.6.5.3 1.6.99.3] [KO:K03942] [EC:1.6.99.3 1.6.5.3]
706067  
NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa [KO:K03943] [EC:1.6.99.3 1.6.5.3]
713739  
NADH dehydrogenase [ubiquinone] flavoprotein 2; K03943 NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:1.6.5.3 1.6.99.3] [KO:K03943] [EC:1.6.99.3 1.6.5.3]
711626  
NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa pseudogene [KO:K03945]
694635  
NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa [KO:K03945]
697736  
NDUFA2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa [KO:K03946]
710937  
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like; K03947 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3 [KO:K03947]
713369  
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like; K03947 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3 [KO:K03947]
705004  
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like; K03947 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3 [KO:K03947]
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like; K03948 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4 [KO:K03948]
641333  
NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa [KO:K03948]
714483  
NDUFA4L2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 [KO:K03948]
705498  
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like; K03948 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4 [KO:K03948]
696324  
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like; K03948 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4 [KO:K03948]
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like; K03948 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4 [KO:K03948]
695066  
NDUFA5; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa [KO:K03949]
698545  
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like; K03949 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5 [KO:K03949]
694520  
NDUFA5; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa [KO:K03949]
NDUFA5; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa [KO:K03949]
709640  
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6-like; K03950 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6 [KO:K03950]
711212  
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like; K03951 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7 [KO:K03951]
698706  
NDUFA8; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa [KO:K03952]
721906  
NDUFA9; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa [KO:K03953]
697681  
NDUFA10; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa [KO:K03954]
700718  
NDUFAB1; NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa [KO:K03955]
715222  
NDUFAB1; NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa [KO:K03955]
711541  
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like; K03956 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11 [KO:K03956]
711970  
NDUFA12; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 [KO:K11352]
716666  
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13-like; K11353 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13 [KO:K11353]
693431  
NDUFB2; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa [KO:K03958]
700944  
NDUFB3; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa [KO:K03959]
699693  
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like; K03959 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3 [KO:K03959]
694795  
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like; K03959 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3 [KO:K03959]
715216  
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like; K03959 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3 [KO:K03959]
713428  
NDUFB4; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa [KO:K03960]
708821  
NDUFB5; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa [KO:K03961]
704867  
NDUFB6; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa [KO:K03962]
717849  
NDUFB7; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa [KO:K03963]
693813  
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8; K03964 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8 [KO:K03964]
710521  
NDUFB8; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa [KO:K03964]
711899  
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8; K03964 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8 [KO:K03964]
718711  
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8; K03964 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8 [KO:K03964]
711387  
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9-like; K03965 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9 [KO:K03965]
693482  
NDUFB10; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa [KO:K03966]
705984  
NDUFB11; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa [KO:K11351]
706912  
NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) [KO:K03934] [EC:1.6.99.3 1.6.5.3]
719935  
NDUFS2; NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) [KO:K03935] [EC:1.6.99.3 1.6.5.3]
713040  
NDUFS3; NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) [KO:K03936] [EC:1.6.99.3 1.6.5.3]
704137  
NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) [KO:K03937]
709249  
NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) [KO:K03938]
693506  
NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) [KO:K03938]
709426  
NDUFS6; NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) [KO:K03939]
721259  
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7; K03940 NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:1.6.5.3 1.6.99.3] [KO:K03940] [EC:1.6.99.3 1.6.5.3]
710845  
NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) [KO:K03941] [EC:1.6.99.3 1.6.5.3]
697242  
NDUFC1; NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa [KO:K03967]
NDUFC2; NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa [KO:K03968]
708018  
succinate dehydrogenase [ubiquinone] flavoprotein subunit; K00234 succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1] [KO:K00234] [EC:1.3.5.1]
723442  
succinate dehydrogenase [ubiquinone] flavoprotein subunit; K00234 succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1] [KO:K00234] [EC:1.3.5.1]
699810  
SDHB; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [KO:K00235] [EC:1.3.5.1]
702309  
succinate dehydrogenase cytochrome b560 subunit; K00236 succinate dehydrogenase (ubiquinone) cytochrome b560 subunit [KO:K00236]
719978  
SDHC; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa [KO:K00236]
704336  
succinate dehydrogenase cytochrome b560 subunit; K00236 succinate dehydrogenase (ubiquinone) cytochrome b560 subunit [KO:K00236]
701966  
succinate dehydrogenase cytochrome b560 subunit; K00236 succinate dehydrogenase (ubiquinone) cytochrome b560 subunit [KO:K00236]
711326  
SDHD; succinate dehydrogenase complex, subunit D, integral membrane protein [KO:K00237]
700693  
SDHD; succinate dehydrogenase complex, subunit D, integral membrane protein [KO:K00237]
705178  
UQCRFS1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [KO:K00411] [EC:1.10.2.2]
CYTB; cytochrome b [KO:K00412]
700518  
CYC1; cytochrome c-1 [KO:K00413]
677864  
UQCRC1; ubiquinol-cytochrome c reductase core protein I [KO:K00414]
697967  
UQCRC2; ubiquinol-cytochrome c reductase core protein II [KO:K00415]
695396  
UQCRH; ubiquinol-cytochrome c reductase hinge protein-like [KO:K00416]
701662  
UQCRH; ubiquinol-cytochrome c reductase hinge protein pseudogene [KO:K00416]
707968  
UQCRH; ubiquinol-cytochrome c reductase hinge protein [KO:K00416]
705124  
UQCRB; ubiquinol-cytochrome c reductase binding protein [KO:K00417]
701223  
UQCRB; ubiquinol-cytochrome c reductase binding protein [KO:K00417]
uncharacterized LOC100427118; K00417 ubiquinol-cytochrome c reductase subunit 7 [KO:K00417]
695665  
UQCRQ; ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa-like [KO:K00418]
708950  
UQCRQ; ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa [KO:K00418]
720636  
cytochrome b-c1 complex subunit 9-like; K00419 ubiquinol-cytochrome c reductase subunit 9 [KO:K00419]
708396  
UQCR; ubiquinol-cytochrome c reductase, 6.4kDa subunit [KO:K00420]
COX3; cytochrome c oxidase subunit III [KO:K02262]
COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:1.9.3.1]
COX2; cytochrome c oxidase subunit II [KO:K02261]
714951  
cytochrome c oxidase subunit IV isoform 1-like; K02263 cytochrome c oxidase subunit 4 [KO:K02263]
693811  
COX4I1; cytochrome c oxidase subunit IV isoform 1 [KO:K02263]
713095  
COX4I2; cytochrome c oxidase subunit IV isoform 2 (lung) [KO:K02263]
692061  
COX5A; cytochrome c oxidase subunit 5A [KO:K02264]
701661  
cytochrome c oxidase subunit 5B; K02265 cytochrome c oxidase subunit 5b [KO:K02265]
710274  
cytochrome c oxidase subunit 5B; K02265 cytochrome c oxidase subunit 5b [KO:K02265]
707227  
cytochrome c oxidase subunit 5B; K02265 cytochrome c oxidase subunit 5b [KO:K02265]
713995  
COX6A2; cytochrome c oxidase subunit VIa polypeptide 2 [KO:K02266]
696956  
cytochrome c oxidase subunit 6A1; K02266 cytochrome c oxidase subunit 6a [KO:K02266]
COX6B2; cytochrome c oxidase subunit 6B2 [KO:K02267]
692062  
COX6B1; cytochrome c oxidase subunit 6B [KO:K02267]
717143  
cytochrome c oxidase subunit 6B1-like; K02267 cytochrome c oxidase subunit 6b [KO:K02267]
703685  
cytochrome c oxidase subunit 6C-like; K02268 cytochrome c oxidase subunit 6c [KO:K02268]
cytochrome c oxidase subunit 6C-like; K02268 cytochrome c oxidase subunit 6c [KO:K02268]
cytochrome c oxidase subunit 6C-like; K02268 cytochrome c oxidase subunit 6c [KO:K02268]
701601  
cytochrome c oxidase subunit 7A2; K02270 cytochrome c oxidase subunit 7a [KO:K02270]
692060  
COX7AH; cytochrome c oxidase subunit 7AH [KO:K02270]
703896  
cytochrome c oxidase subunit 7A2; K02270 cytochrome c oxidase subunit 7a [KO:K02270]
700525  
uncharacterized LOC700525; K02270 cytochrome c oxidase subunit 7a [KO:K02270]
707203  
cytochrome c oxidase subunit 7A-related protein; K02270 cytochrome c oxidase subunit 7a [KO:K02270]
706099  
COX7B; cytochrome c oxidase subunit VIIb [KO:K02271]
COX7B2; cytochrome c oxidase subunit VIIb2 [KO:K02271]
693275  
cytochrome c oxidase subunit 7C; K02272 cytochrome c oxidase subunit 7c [KO:K02272]
706698  
cytochrome c oxidase subunit 7C; K02272 cytochrome c oxidase subunit 7c [KO:K02272]
702058  
cytochrome c oxidase subunit 7C; K02272 cytochrome c oxidase subunit 7c [KO:K02272]
COX7C; cytochrome c oxidase subunit VIIc [KO:K02272]
cytochrome c oxidase subunit 7C; K02272 cytochrome c oxidase subunit 7c [KO:K02272]
718007  
COX8A; cytochrome c oxidase subunit VIIIA (ubiquitous) [KO:K02273]
701389  
ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle [KO:K02132]
705465  
ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [KO:K02133] [EC:3.6.3.14]
713284  
ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [KO:K02133] [EC:3.6.3.14]
713768  
ATP synthase subunit gamma; K02136 F-type H+-transporting ATPase subunit gamma [KO:K02136]
705944  
ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit [KO:K02134]
574260  
ATP5E; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit [KO:K02135]
ATP6; ATP synthase F0 subunit 6 [KO:K02126]
701105  
ATP5F1; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 [KO:K02127]
704072  
ATP5F1; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 [KO:K02127]
711417  
ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)-like [KO:K02128]
706691  
ATP5G3; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)-like [KO:K02128]
697950  
ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) [KO:K02128]
703751  
ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) [KO:K02128]
707476  
ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)-like [KO:K02128]
696144  
ATP5G3; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)-like [KO:K02128]
700815  
ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)-like [KO:K02128]
694260  
ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)-like [KO:K02128]
702893  
ATP5G3; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) [KO:K02128]
711773  
ATP synthase lipid-binding protein; K02128 F-type H+-transporting ATPase subunit c [KO:K02128]
700338  
ATP5H; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d [KO:K02138]
696788  
ATP synthase subunit d; K02138 F-type H+-transporting ATPase subunit d [KO:K02138]
699117  
ATP synthase subunit d; K02138 F-type H+-transporting ATPase subunit d [KO:K02138]
698480  
ATP5O; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit [KO:K02137]
704634  
ATP5O; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit-like [KO:K02137]
708411  
ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 [KO:K02131]
ATP8; ATP synthase F0 subunit 8 [KO:K02125]
697930  
LRRK2; leucine-rich repeat kinase 2 [KO:K08844] [EC:2.7.11.1]
698013  
serine/threonine-protein kinase PINK1; K05688 PTEN induced putative kinase 1 [EC:2.7.11.1] [KO:K05688] [EC:2.7.11.1]
706037  
PINK1; PTEN induced putative kinase 1 [KO:K05688] [EC:2.7.11.1]
708377  
PARK7; protein DJ-1-like [KO:K05687]
709938  
HTRA2; HtrA serine peptidase 2 [KO:K08669] [EC:3.4.21.108]
710045  
VDAC1; voltage-dependent anion channel 1 [KO:K05862]
704257  
VDAC2; voltage-dependent anion channel 2 [KO:K15040]
705116  
VDAC3; voltage-dependent anion-selective channel protein 3-like [KO:K15041]
695102  
SLC25A4; solute carrier family 25 (mitochondrial carrier [KO:K05863]
710042  
SLC25A31; solute carrier family 25 (mitochondrial carrier [KO:K05863]
719811  
SLC25A6; solute carrier family 25 (mitochondrial carrier [KO:K05863]
693502  
SLC25A5; solute carrier family 25 (mitochondrial carrier [KO:K05863]
574137  
PPIF; peptidylprolyl isomerase F [KO:K09565] [EC:5.2.1.8]
705449  
cytochrome c-like; K08738 cytochrome c [KO:K08738]
695875  
cytochrome c-like; K08738 cytochrome c [KO:K08738]
716056  
cytochrome c-like; K08738 cytochrome c [KO:K08738]
711309  
cytochrome c-like; K08738 cytochrome c [KO:K08738]
694977  
cytochrome c pseudogene; K08738 cytochrome c [KO:K08738]
698225  
cytochrome c-like; K08738 cytochrome c [KO:K08738]
701246  
cytochrome c-like; K08738 cytochrome c [KO:K08738]
699951  
cytochrome c-like; K08738 cytochrome c [KO:K08738]
702488  
cytochrome c-like; K08738 cytochrome c [KO:K08738]
CYCS; cytochrome c, somatic [KO:K08738]
694164  
APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
694544  
CASP9; caspase 9, apoptosis-related cysteine peptidase [KO:K04399] [EC:3.4.22.62]
694473  
CASP3; caspase 3, apoptosis-related cysteine peptidase [KO:K02187] [EC:3.4.22.56]
619515  
 
703470  
 
Compound
C00002  
ATP
C00008  
ADP
C00009  
Orthophosphate
C00013  
Diphosphate
C00020  
AMP
C00027  
Hydrogen peroxide
C00082  
L-Tyrosine
C00212  
Adenosine
C00355  
3,4-Dihydroxy-L-phenylalanine
C00575  
3',5'-Cyclic AMP
C00704  
O2.-
C03758  
Dopamine
C04599  
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  
Rotenone
C11310  
1-Methyl-4-phenylpyridinium
Reference
  Authors
Thomas B, Beal MF
  Title
Parkinson's disease.
  Journal
Hum Mol Genet 16 Spec No. 2:R183-94 (2007)
Reference
  Authors
Lim KL, Lim TM
  Title
Molecular mechanisms of neurodegeneration in Parkinson's disease: clues from Mendelian syndromes.
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