KEGG   PATHWAY: mce00010
Entry
mce00010                    Pathway                                
Name
Glycolysis / Gluconeogenesis - Mycobacterium canettii CIPT 140010059
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
mce00010  Glycolysis / Gluconeogenesis
mce00010

Module
mce_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:mce00010]
mce_M00002  Glycolysis, core module involving three-carbon compounds [PATH:mce00010]
mce_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:mce00010]
mce_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:mce00010]
Other DBs
GO: 0006096 0006094
Organism
Mycobacterium canettii CIPT 140010059 [GN:mce]
Gene
MCAN_06491  putative SUGAR kinase [KO:K25026] [EC:2.7.1.2]
MCAN_09501  pgi; putative glucose-6-phosphate isomerase PGI (GPI) (phosphoglucose isomerase) (phosphohexose isomerase) (PHI) [KO:K01810] [EC:5.3.1.9]
MCAN_20521  pfkB; putative phosphofructokinase PfkB (phosphohexokinase) [KO:K16370] [EC:2.7.1.11]
MCAN_30331  pfkA; putative 6-phosphofructokinase PFKA (phosphohexokinase) (phosphofructokinase) [KO:K21071] [EC:2.7.1.11 2.7.1.90]
MCAN_11081  conserved hypothetical protein [KO:K02446] [EC:3.1.3.11]
MCAN_03641  fba; putative fructose-bisphosphate aldolase FBA [KO:K01624] [EC:4.1.2.13]
MCAN_14541  tpi; putative triosephosphate isomerase TPI (TIM) [KO:K01803] [EC:5.3.1.1]
MCAN_14521  gap; putative glyceraldehyde 3-phosphate dehydrogenase GAP (GAPDH) [KO:K00134] [EC:1.2.1.12]
MCAN_14531  pgk; putative phosphoglycerate kinase PGK [KO:K00927] [EC:2.7.2.3]
MCAN_04891  gpm1; putative phosphoglycerate mutase 1 GPM1 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) [KO:K01834] [EC:5.4.2.11]
MCAN_10281  eno; putative enolase ENO [KO:K01689] [EC:4.2.1.11]
MCAN_16251  pykA; putative pyruvate kinase pykA [KO:K00873] [EC:2.7.1.40]
MCAN_11361  ppdK; putative pyruvate, phosphate dikinase PPDK [KO:K01006] [EC:2.7.9.1]
MCAN_22631  aceE; putative pyruvate dehydrogenase E1 component aceE (pyruvate decarboxylase) (pyruvate dehydrogenase) (pyruvic dehydrogenase) [KO:K00163] [EC:1.2.4.1]
MCAN_22371  sucB; putative pyruvate dehydrogenase (E2 component) SucB [KO:K00627] [EC:2.3.1.12]
MCAN_04611  lpd; dihydrolipoamide dehydrogenase LPD (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphorase) [KO:K00382] [EC:1.8.1.4]
MCAN_24941  putative oxidoreductase (alpha subunit) [KO:K00174] [EC:1.2.7.3 1.2.7.11]
MCAN_24931  putative oxidoreductase (beta subunit) [KO:K00175] [EC:1.2.7.3 1.2.7.11]
MCAN_07651  adhB; putative Zinc-containing alcohol dehydrogenase NAD dependent ADHB [KO:K00121] [EC:1.1.1.284 1.1.1.1]
MCAN_18771  adhA; putative alcohol dehydrogenase adhA [KO:K13953] [EC:1.1.1.1]
MCAN_01681  adhE1; putative zinc-type alcohol dehydrogenase (E subunit) ADHE [KO:K00001] [EC:1.1.1.1]
MCAN_15531  adh; putative alcohol dehydrogenase adh [KO:K00001] [EC:1.1.1.1]
MCAN_30701  adhC; putative NADP-dependent alcohol dehydrogenase ADHC [KO:K13979] [EC:1.1.1.2]
MCAN_01501  putative aldehyde dehydrogenase (NAD+) dependent [KO:K00128] [EC:1.2.1.3]
MCAN_02291  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
MCAN_07721  aldA; putative aldehyde dehydrogenase NAD dependent ALDA (aldehyde dehydrogenase [NAD+]) [KO:K00128] [EC:1.2.1.3]
MCAN_04571  putative aldehyde dehydrogenase [KO:K00138] [EC:1.2.1.-]
MCAN_36871  acs; acetyl-coenzyme A synthetase ACS (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (acetate thiokinase) (acetyl-activating enzyme) (acetate--coenzyme A ligase) (acetyl-coenzyme A synthase) [KO:K01895] [EC:6.2.1.1]
MCAN_30931  pgmA; putative phosphoglucomutase PGMA (glucose phosphomutase) (PGM) [KO:K01835] [EC:5.4.2.2]
MCAN_27281  ppgK; polyphosphate glucokinase PPGK (polyphosphate-glucose phosphotransferase) [KO:K00886] [EC:2.7.1.63]
MCAN_02171  pckA; putative iron-regulated phosphoenolpyruvate carboxykinase [GTP] PCKA (phosphoenolpyruvate carboxylase) (PEPCK)(PEP carboxykinase) [KO:K01596] [EC:4.1.1.32]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
mce00020  Citrate cycle (TCA cycle)
mce00030  Pentose phosphate pathway
mce00500  Starch and sucrose metabolism
mce00620  Pyruvate metabolism
mce00640  Propanoate metabolism
KO pathway
ko00010   

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