KEGG   PATHWAY: mdo04610Help
Entry
mdo04610                    Pathway                                
Name
Complement and coagulation cascades - Monodelphis domestica (opossum)
Description
The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, in turn, generates the effector molecules of complement. The main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Blood coagulation is another series of proenzyme-to-serine protease conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Complement and coagulation cascades
mdo04610

All organismsOrtholog table
Organism
Monodelphis domestica (opossum) [GN:mdo]
Gene
coagulation factor XII-like; K01328 coagulation factor XII (Hageman factor) [EC:3.4.21.38] [KO:K01328] [EC:3.4.21.38]
KLKB1; kallikrein B, plasma (Fletcher factor) 1 [KO:K01324] [EC:3.4.21.34]
b1 bradykinin receptor-like; K03915 bradykinin receptor B1 [KO:K03915]
b2 bradykinin receptor-like; K03916 bradykinin receptor B2 [KO:K03916]
F11; coagulation factor XI [KO:K01323] [EC:3.4.21.27]
F9; coagulation factor IX [KO:K01321] [EC:3.4.21.22]
coagulation factor VIII-like; K03899 coagulation factor VIII [KO:K03899]
VWF; von Willebrand factor [KO:K03900]
tissue factor-like; K03901 coagulation factor III (tissue factor) [KO:K03901]
coagulation factor VII-like; K01320 coagulation factor VII [EC:3.4.21.21] [KO:K01320] [EC:3.4.21.21]
F10; coagulation factor X [KO:K01314] [EC:3.4.21.6]
F5; coagulation factor V (proaccelerin, labile factor) [KO:K03902]
prothrombin-like; K01313 coagulation factor II (thrombin) [EC:3.4.21.5] [KO:K01313] [EC:3.4.21.5]
FGA; fibrinogen alpha chain [KO:K03903]
FGB; fibrinogen beta chain [KO:K03904]
FGG; fibrinogen gamma chain [KO:K03905]
F13A1; coagulation factor XIII, A1 polypeptide [KO:K03917] [EC:2.3.2.13]
F13B; coagulation factor XIII, B polypeptide [KO:K03906]
thrombomodulin-like; K03907 thrombomodulin [KO:K03907]
vitamin K-dependent protein C-like; K01344 protein C (activated) [EC:3.4.21.69] [KO:K01344] [EC:3.4.21.69]
vitamin K-dependent protein S-like; K03908 protein S [KO:K03908]
tissue-type plasminogen activator-like; K01343 tissue plasminogen activator [EC:3.4.21.68] [KO:K01343] [EC:3.4.21.68]
urokinase-type plasminogen activator-like; K01348 urokinase plasminogen activator [EC:3.4.21.73] [KO:K01348] [EC:3.4.21.73]
plasminogen-like; K01315 plasminogen [EC:3.4.21.7] [KO:K01315] [EC:3.4.21.7]
tissue factor pathway inhibitor-like; K03909 tissue factor pathway inhibitor [KO:K03909]
carboxypeptidase B2-like; K01300 carboxypeptidase B2 [EC:3.4.17.20] [KO:K01300] [EC:3.4.17.20]
plasminogen activator inhibitor 1-like; K03982 plasminogen activator inhibitor-1 [KO:K03982]
antithrombin-III-like; K03911 antithrombin III [KO:K03911]
alpha-2-macroglobulin-like; K03910 alpha-2-macroglobulin [KO:K03910]
alpha-1-antiproteinase-like; K03984 alpha-1-antitrypsin [KO:K03984]
proteinase-activated receptor 1-like; K03914 coagulation factor II (thrombin) receptor [KO:K03914]
uncharacterized LOC100029145; K03985 plasminogen activator, urokinase receptor [KO:K03985]
complement C1q subcomponent subunit A-like; K03986 complement C1q subcomponent subunit A [KO:K03986]
complement C1q subcomponent subunit B-like; K03987 complement C1q subcomponent subunit B [KO:K03987]
complement C1q subcomponent subunit C-like; K03988 complement C1q subcomponent subunit C [KO:K03988]
complement C1r subcomponent-like; K01330 complement component 1, r subcomponent [EC:3.4.21.41] [KO:K01330] [EC:3.4.21.41]
complement C1s subcomponent-like; K01331 complement component 1, s subcomponent [EC:3.4.21.42] [KO:K01331] [EC:3.4.21.42]
complement C2-like; K01332 complement component 2 [EC:3.4.21.43] [KO:K01332] [EC:3.4.21.43]
C4A; complement component 4A (Rodgers blood group) [KO:K03989]
complement C3-like; K03990 complement component 3 [KO:K03990]
complement factor B-like; K01335 component factor B [EC:3.4.21.47] [KO:K01335] [EC:3.4.21.47]
mannose-binding protein A-like; K03991 mannose-binding lectin [KO:K03991]
uncharacterized LOC100012016; K03992 mannan-binding lectin serine protease 1 [EC:3.4.21.-] [KO:K03992] [EC:3.4.21.-]
MASP2; mannan-binding lectin serine peptidase 2 [KO:K03993] [EC:3.4.21.104]
C5; complement component 5 [KO:K03994]
complement component C6-like; K03995 complement component 6 [KO:K03995]
complement component C7-like; K03996 complement component 7 [KO:K03996]
C8A; complement component 8, alpha polypeptide [KO:K03997]
complement component C8 beta chain-like; K03998 complement component 8 subunit beta [KO:K03998]
uncharacterized LOC100022339; K03999 complement component 8 subunit gamma [KO:K03999]
complement component C9-like; K04000 complement component 9 [KO:K04000]
plasma protease C1 inhibitor-like; K04001 C1 inhibitor [KO:K04001]
c4b-binding protein alpha chain-like; K04002 complement component 4 binding protein, alpha [KO:K04002]
c4b-binding protein beta chain-like; K04003 complement component 4 binding protein, beta [KO:K04003]
complement factor H-like; K04004 complement factor H [KO:K04004]
CFI; complement factor I [KO:K01333] [EC:3.4.21.45]
complement decay-accelerating factor-like; K04006 decay accelerating factor [KO:K04006]
c3a anaphylatoxin chemotactic receptor-like; K04009 C3a anaphylatoxin chemotactic receptor [KO:K04009]
c5a anaphylatoxin chemotactic receptor-like; K04010 C5a anaphylatoxin chemotactic receptor [KO:K04010]
complement receptor type 1-like; K04012 complement receptor type 2 [KO:K04012]
Compound
C00290  
Fibrin
C00306  
Bradykinin
Reference
  Authors
Norris LA.
  Title
Blood coagulation.
  Journal
Best Pract Res Clin Obstet Gynaecol 17:369-83 (2003)
Reference
  Authors
Mann KG.
  Title
Thrombin formation.
  Journal
Chest 124:4S-10S (2003)
Reference
  Authors
Bhole D, Stahl GL.
  Title
Therapeutic potential of targeting the complement cascade in critical care medicine.
  Journal
Crit Care Med 31:S97-104 (2003)
Reference
  Authors
Turnberg D, Botto M.
  Title
The regulation of the complement system: insights from genetically-engineered mice.
  Journal
Mol Immunol 40:145-53 (2003)
Reference
  Authors
Campbell DJ.
  Title
The kallikrein-kinin system in humans.
  Journal
Clin Exp Pharmacol Physiol 28:1060-5 (2001)
Reference
  Authors
Ueno A, Oh-ishi S.
  Title
Roles for the kallikrein-kinin system in inflammatory exudation and pain: lessons from studies on kininogen-deficient rats.
  Journal
J Pharmacol Sci 93:1-20 (2003)
Reference
  Authors
Ruf W, Dorfleutner A, Riewald M.
  Title
Specificity of coagulation factor signaling.
  Journal
J Thromb Haemost 1:1495-503 (2003)
Reference
  Authors
Mazar AP, Henkin J, Goldfarb RH.
  Title
The urokinase plasminogen activator system in cancer: implications for tumor angiogenesis and metastasis.
  Journal
Angiogenesis 3:15-32 (1999)
Reference
  Authors
Markovic SN, Inwards DJ, Frigas EA, Phyliky RP.
  Title
Acquired C1 esterase inhibitor deficiency.
  Journal
Ann Intern Med 132:144-50 (2000)
Reference
  Authors
Schmaier AH.
  Title
The plasma kallikrein-kinin system counterbalances the renin-angiotensin system.
  Journal
J Clin Invest 109:1007-9 (2002)
Reference
  Authors
Velasco-Velazquez MA, Barrera D, Gonzalez-Arenas A, Rosales C, Agramonte-Hevia J.
  Title
Macrophage--Mycobacterium tuberculosis interactions: role of complement receptor 3.
  Journal
Microb Pathog 35:125-31 (2003)
Reference
  Authors
Kim SJ, Gershov D, Ma X, Brot N, Elkon KB.
  Title
Opsonization of apoptotic cells and its effect on macrophage and T cell immune responses.
  Journal
Ann N Y Acad Sci 987:68-78 (2003)
Reference
  Authors
Matsushita M, Thiel S, Jensenius JC, Terai I, Fujita T.
  Title
Proteolytic activities of two types of mannose-binding lectin-associated serine protease.
  Journal
J Immunol 165:2637-42 (2000)
KO pathway
 
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