KEGG PATHWAY: mdo04662

PATHWAY: mdo04662

Entry

mdo04662 Pathway

Name

B cell receptor signaling pathway - Monodelphis domestica (opossum)

Description

B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.

Class

Organismal Systems; Immune system

Pathway map

mdo04662

B cell receptor signaling pathway

Other DBs

BSID:

87182

GO:

0050853

Organism

Monodelphis domestica (opossum) [GN:mdo]

Gene

100618912	ig heavy chain V-III region VH26-like; K06856 immunoglobulin heavy chain [KO:K06856]
100618709	ig heavy chain V-III region VH26-like; K06856 immunoglobulin heavy chain [KO:K06856]
100618872	ig heavy chain V-III region VH26-like; K06856 immunoglobulin heavy chain [KO:K06856]
100619427	ig heavy chain V-III region VH26-like; K06856 immunoglobulin heavy chain [KO:K06856]
100500766	CD79a; K06506 CD79A antigen [KO:K06506]
100026330	CD79b; CD79b molecule, immunoglobulin-associated beta [KO:K06507]
100616821	tyrosine-protein kinase Lyn-like; K05854 tyrosine-protein kinase Lyn [EC:2.7.10.2] [KO:K05854] [EC:2.7.10.2]
100028356	tyrosine-protein kinase SYK-like; K05855 spleen tyrosine kinase [EC:2.7.10.2] [KO:K05855] [EC:2.7.10.2]
100022891	tyrosine-protein kinase BTK-like; K07370 Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] [KO:K07370] [EC:2.7.10.2]
100015430	dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide-like; K12229 dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [KO:K12229]
100022658	b-cell linker protein-like; K07371 B-cell linker protein [KO:K07371]
100029844	VAV3; vav 3 guanine nucleotide exchange factor [KO:K05730]
100015350	VAV2; vav 2 guanine nucleotide exchange factor [KO:K05730]
100020150	VAV1; vav 1 guanine nucleotide exchange factor [KO:K05730]
100026992	ras-related C3 botulinum toxin substrate 1-like; K04392 Ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100017517	ras-related C3 botulinum toxin substrate 2-like; K07860 Ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100029873	ras-related C3 botulinum toxin substrate 3-like; K07861 Ras-related C3 botulinum toxin substrate 3 [KO:K07861]
100027579	PLCG2; phospholipase C, gamma 2 (phosphatidylinositol-specific) [KO:K05859] [EC:3.1.4.11]
100014900	PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
100011077	PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
100033104	PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
100027667	calcium-binding protein p22-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
100033302	calcineurin subunit B type 1-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
100025432	NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 [KO:K04446]
100028106	NFAT5; nuclear factor of activated T-cells 5, tonicity-responsive [KO:K04446]
100028435	nuclear factor of activated T-cells; K04446 nuclear factor of activated T-cells, cytoplasmic [KO:K04446]
100023153	NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [KO:K04446]
100021991	NFATC3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 [KO:K04446]
100022894	growth factor receptor-bound protein 2-like; K04364 growth factor receptor-binding protein 2 [KO:K04364]
100618058	son of sevenless homolog 1-like; K03099 son of sevenless [KO:K03099]
100029256	SOS2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
100031591	RASGRP3; RAS guanyl releasing protein 3 (calcium and DAG-regulated) [KO:K12362]
100032921	GTPase HRas-like; K02833 GTPase HRas [KO:K02833]
100009992	GTPase KRas-like; K07827 GTPase KRas [KO:K07827]
554186	KRAS; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
554197	NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
100015410	RAF proto-oncogene serine/threonine-protein kinase-like; K04366 RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] [KO:K04366] [EC:2.7.11.1]
100018410	MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100018044	dual specificity mitogen-activated protein kinase kinase 2-like; K04369 mitogen-activated protein kinase kinase 2 [EC:2.7.12.2] [KO:K04369] [EC:2.7.12.2]
100028096	mitogen-activated protein kinase 1-like; K04371 extracellular signal-regulated kinase 1/2 [EC:2.7.11.24] [KO:K04371] [EC:2.7.11.24]
100012916	MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100018285	proto-oncogene c-Fos-like; K04379 proto-oncogene protein c-fos [KO:K04379]
100018774	transcription factor AP-1-like; K04448 transcription factor AP-1 [KO:K04448]
100012814	CARD11; caspase recruitment domain family, member 11 [KO:K07367]
100011950	b-cell lymphoma/leukemia 10-like; K07368 B-cell CLL/lymphoma 10 [KO:K07368]
100016169	MALT1; mucosa associated lymphoid tissue lymphoma translocation gene 1 [KO:K07369] [EC:3.4.22.-]
100027952	CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
100033031	IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
100022918	NF-kappa-B essential modulator-like; K07210 inhibitor of nuclear factor kappa-B kinase subunit gamma [KO:K07210]
100014446	NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
100030053	transcription factor p65-like; K04735 transcription factor p65 [KO:K04735]
100011769	NF-kappa-B inhibitor alpha-like; K04734 NF-kappa-B inhibitor alpha [KO:K04734]
100013691	NF-kappa-B inhibitor beta-like; K02581 NF-kappa-B inhibitor beta [KO:K02581]
100013226	NF-kappa-B inhibitor epsilon-like; K05872 NF-kappa-B inhibitor epsilon [KO:K05872]
100020467	complement receptor type 1-like; K04012 complement receptor type 2 [KO:K04012]
100019317	PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
100012464	PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
100032726	phosphatidylinositol 3-kinase regulatory subunit beta-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
100009879	phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
100010412	phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
100017332	phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
100014564	AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
100019947	RAC-alpha serine/threonine-protein kinase-like; K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] [KO:K04456] [EC:2.7.11.1]
100027373	AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
100012447	GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
100021361	INPP5D; inositol polyphosphate-5-phosphatase, 145kDa [KO:K03084] [EC:3.1.3.86]
100015500	INPPL1; inositol polyphosphate phosphatase-like 1 [KO:K15909] [EC:3.1.3.86]
100015727	CD22; CD22 molecule [KO:K06467]
100016514	PTPN6; protein tyrosine phosphatase, non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
100022409	phosphoinositide 3-kinase adapter protein 1-like; K12230 phosphoinositide 3-kinase adapter protein 1 [KO:K12230]

Compound

C00076	Calcium cation
C00165	Diacylglycerol
C01245	D-myo-Inositol 1,4,5-trisphosphate
C05981	Phosphatidylinositol-3,4,5-trisphosphate

Reference

PMID:12461567

Authors

Niiro H, Clark EA.

Title

Regulation of B-cell fate by antigen-receptor signals.

Journal

Nat Rev Immunol 2:945-56 (2002)

Reference

PMID:10358768

Authors

Kurosaki T.

Title

Genetic analysis of B cell antigen receptor signaling.

Journal

Annu Rev Immunol 17:555-92 (1999)

Reference

PMID:15886119

Authors

Nitschke L.

Title

The role of CD22 and other inhibitory co-receptors in B-cell activation.

Journal

Curr Opin Immunol 17:290-7 (2005)

Reference

PMID:15752555

Authors

Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.

Title

Complement: central to innate immunity and bridging to adaptive responses.

Journal

Immunol Lett 97:171-9 (2005)

Reference

PMID:12033741

Authors

Kurosaki T.

Title

Regulation of B-cell signal transduction by adaptor proteins.

Journal

Nat Rev Immunol 2:354-63 (2002)

Reference

PMID:15364057

Authors

Nitschke L, Tsubata T.

Title

Molecular interactions regulate BCR signal inhibition by CD22 and CD72.

Journal

Trends Immunol 25:543-50 (2004)

Reference

PMID:15771577

Authors

Jumaa H, Hendriks RW, Reth M.

Title

B cell signaling and tumorigenesis.

Journal

Annu Rev Immunol 23:415-45 (2005)

Reference

PMID:15886112

Authors

Rickert RC.

Title

Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.

Journal

Curr Opin Immunol 17:237-43 (2005)

Reference

PMID:15457440

Authors

Zouali M, Sarmay G.

Title

B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.

Journal

Arthritis Rheum 50:2730-41 (2004)

Reference

PMID:15322145

Authors

Chiles TC.

Title

Regulation and function of cyclin D2 in B lymphocyte subsets.

Journal

J Immunol 173:2901-7 (2004)

Reference

PMID:15626471

Authors

Allam A, Marshall AJ

Title

Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.

Journal

Immunol Lett 97:7-17 (2005)

Reference

PMID:12119152

Authors

Gold MR

Title

To make antibodies or not: signaling by the B-cell antigen receptor.

Journal

Trends Pharmacol Sci 23:316-24 (2002)

Reference

PMID:9697839

Authors

Fu C, Turck CW, Kurosaki T, Chan AC

Title

BLNK: a central linker protein in B cell activation.

Journal

Immunity 9:93-103 (1998)

Reference

PMID:11163197

Authors

Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T

Title

BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.

Journal

Immunity 13:817-27 (2000)

Reference

PMID:18086859

Authors

Shinohara H, Maeda S, Watarai H, Kurosaki T

Title

IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.

Journal

J Exp Med 204:3285-93 (2007)

KO pathway

ko04662

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (70)   
   KEGG GENES (70)   
All databases (72)   

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