KEGG   PATHWAY: mir03440Help
Entry
mir03440                    Pathway                                

Name
Homologous recombination - Mycobacterium paraintracellulare
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
mir03440  Homologous recombination
mir03440

Ortholog table
Module
mir_M00260  DNA polymerase III complex, bacteria [PATH:mir03440]
Other DBs
BSID: 583897
GO: 0000724
Organism
Mycobacterium paraintracellulare [GN:mir]
Gene
OCQ_00710  single-stranded DNA-binding protein [KO:K03111]
OCQ_15190  hypothetical protein [KO:K03111]
OCQ_00030  recombination protein F [KO:K03629]
OCQ_18840  DNA repair protein RecO [KO:K03584]
OCQ_03420  recombination protein RecR [KO:K06187]
OCQ_35760  recombinase A [KO:K03553]
OCQ_30650  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
OCQ_34240  holliday junction DNA helicase motor protein [KO:K03550] [EC:3.6.4.12]
OCQ_34230  holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
OCQ_34250  holliday junction resolvase [KO:K01159] [EC:3.1.22.4]
OCQ_37560  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
OCQ_45500  exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
OCQ_45490  exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
OCQ_45510  hypothetical protein [KO:K03581] [EC:3.1.11.5]
OCQ_31360  DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
OCQ_00020  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
OCQ_03360  DNA polymerase III subunit gamma and tau [KO:K02343] [EC:2.7.7.7]
OCQ_15870  hypothetical protein [KO:K02340] [EC:2.7.7.7]
OCQ_04490  DNA-directed DNA polymerase III subunit delta [KO:K02341] [EC:2.7.7.7]
OCQ_03460  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
OCQ_21600  hypothetical protein [KO:K02342] [EC:2.7.7.7]
OCQ_33360  primosome assembly protein PriA [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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