KEGG   PATHWAY: mjl00230
Entry
mjl00230                    Pathway                                
Name
Purine metabolism - Mycobacterium sp. JLS
Class
Metabolism; Nucleotide metabolism
Pathway map
mjl00230  Purine metabolism
mjl00230

Module
mjl_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mjl00230]
mjl_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mjl00230]
mjl_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mjl00230]
mjl_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mjl00230]
mjl_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mjl00230]
mjl_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mjl00230]
Other DBs
GO: 0006163 0042278
Organism
Mycobacterium sp. JLS [GN:mjl]
Gene
Mjls_1707  phosphoglucomutase, alpha-D-glucose phosphate-specific [KO:K01835] [EC:5.4.2.2]
Mjls_4628  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
Mjls_4924  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
Mjls_4954  phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
Mjls_4700  phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
Mjls_0513  formate-dependent phosphoribosylglycinamide formyltransferase [KO:K08289] [EC:6.3.1.21]
Mjls_4929  phosphoribosylformylglycinamidine synthase subunit II [KO:K23269] [EC:6.3.5.3]
Mjls_4936  phosphoribosylformylglycinamidine synthase, purS [KO:K23264] [EC:6.3.5.3]
Mjls_4935  phosphoribosylformylglycinamidine synthase subunit I [KO:K23265] [EC:6.3.5.3 3.5.1.2]
Mjls_4921  phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
Mjls_1334  5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
Mjls_1335  5-(carboxyamino)imidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
Mjls_4943  phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
Mjls_4949  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
Mjls_4699  IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
Mjls_2318  Adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
Mjls_1955  HAD-superfamily hydrolase, subfamily IIA [KO:K02566] [EC:3.1.3.5]
Mjls_1271  purine nucleotide phosphorylase [KO:K03783] [EC:2.4.2.1]
Mjls_3263  protein of unknown function DUF152 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
Mjls_1205  Inosine/uridine-preferring nucleoside hydrolase [KO:K01239] [EC:3.2.2.1]
Mjls_5161  hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
Mjls_1194  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
Mjls_1195  IMP dehydrogenase family protein [KO:K00088] [EC:1.1.1.205]
Mjls_3557  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
Mjls_3829  non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family [KO:K01519] [EC:3.6.1.66]
Mjls_0424  xanthine dehydrogenase, molybdenum binding subunit apoprotein [KO:K11177] [EC:1.17.1.4]
Mjls_0425  molybdopterin dehydrogenase, FAD-binding protein [KO:K11178] [EC:1.17.1.4]
Mjls_0426  (2Fe-2S)-binding domain protein [KO:K13483]
Mjls_1200  GMP synthase (glutamine-hydrolyzing) [KO:K01951] [EC:6.3.5.2]
Mjls_2840  IMP dehydrogenase family protein [KO:K26110] [EC:1.7.1.7]
Mjls_2411  guanylate kinase [KO:K00942] [EC:2.7.4.8]
Mjls_1113  ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [KO:K00525] [EC:1.17.4.1]
Mjls_1798  ribonucleoside-diphosphate reductase class Ib alpha subunit [KO:K00525] [EC:1.17.4.1]
Mjls_1809  ribonucleoside-diphosphate reductase class Ib beta subunit [KO:K00526] [EC:1.17.4.1]
Mjls_4441  putative ribonucleotide reductase small chain [KO:K00526] [EC:1.17.4.1]
Mjls_3454  putative deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
Mjls_2319  (p)ppGpp synthetase I, SpoT/RelA [KO:K01139] [EC:2.7.6.5 3.1.7.2]
Mjls_4616  Ppx/GppA phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
Mjls_0657  Ppx/GppA phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
Mjls_3041  adenylate cyclase [KO:K01768] [EC:4.6.1.1]
Mjls_5181  putative adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
Mjls_3963  putative adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
Mjls_1262  adenylyl cyclase class-3/4/guanylyl cyclase [KO:K01768] [EC:4.6.1.1]
Mjls_3854  putative adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
Mjls_1514  putative adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
Mjls_0462  adenylate cyclase [KO:K01768] [EC:4.6.1.1]
Mjls_3816  putative adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
Mjls_4322  putative adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
Mjls_4534  putative adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
Mjls_0504  Adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
Mjls_3311  Adenosine kinase [KO:K00856] [EC:2.7.1.20]
Mjls_1259  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
Mjls_1075  Adenylate kinase [KO:K00939] [EC:2.7.4.3]
Mjls_4623  MazG nucleotide pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
Mjls_2282  histidine triad (HIT) protein [KO:K19710] [EC:2.7.7.53]
Mjls_0375  adenylylsulfate kinase [KO:K00955] [EC:2.7.7.4 2.7.1.25]
Mjls_3933  adenylylsulfate kinase / sulfate adenylyltransferase subunit 1 [KO:K00955] [EC:2.7.7.4 2.7.1.25]
Mjls_3934  sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
Mjls_0376  sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
Mjls_5166  conserved hypothetical protein [KO:K16840] [EC:4.1.1.97]
Mjls_1033  Asp/Glu racemase [KO:K16841] [EC:5.1.99.3]
Mjls_2022  polysaccharide deacetylase [KO:K16842] [EC:3.5.2.5]
Mjls_5167  Allantoicase [KO:K01477] [EC:3.5.3.4]
Mjls_2832  urease, Metallo peptidase, MEROPS family M38 [KO:K01428] [EC:3.5.1.5]
Mjls_2833  urease, beta subunit [KO:K01429] [EC:3.5.1.5]
Mjls_2834  urease, gamma subunit [KO:K01430] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mjl00030  Pentose phosphate pathway
mjl00220  Arginine biosynthesis
mjl00250  Alanine, aspartate and glutamate metabolism
mjl00260  Glycine, serine and threonine metabolism
mjl00340  Histidine metabolism
mjl00630  Glyoxylate and dicarboxylate metabolism
mjl00730  Thiamine metabolism
mjl00740  Riboflavin metabolism
mjl00790  Folate biosynthesis
KO pathway
ko00230   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (66)   
   KEGG GENES (66)   
All databases (67)   

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