KEGG   PATHWAY: mla02010Help
Entry
mla02010                    Pathway                                

Name
ABC transporters - Methanocorpusculum labreanum
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
mla02010  ABC transporters
mla02010

Ortholog table
Module
mla_M00186  Tungstate transport system [PATH:mla02010]
mla_M00208  Glycine betaine/proline transport system [PATH:mla02010]
mla_M00222  Phosphate transport system [PATH:mla02010]
mla_M00239  Peptides/nickel transport system [PATH:mla02010]
mla_M00240  Iron complex transport system [PATH:mla02010]
mla_M00245  Cobalt/nickel transport system [PATH:mla02010]
mla_M00246  Nickel transport system [PATH:mla02010]
mla_M00423  Molybdate/tungstate transport system [PATH:mla02010]
mla_M00582  Energy-coupling factor transport system [PATH:mla02010]
Other DBs
BSID: 46669
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Methanocorpusculum labreanum [GN:mla]
Gene
Mlab_0465  ABC-type tungstate transport system permease component-like protein [KO:K05772]
Mlab_0466  binding-protein-dependent transport systems inner membrane component [KO:K05773]
Mlab_0467  ABC transporter related protein [KO:K06857] [EC:3.6.3.55]
Mlab_1025  tungstate/molybdate binding protein [KO:K15495]
Mlab_1023  tungstate/molybdate transport system permease protein [KO:K15496]
Mlab_1024  tungstate/molybdate transport system ATP-binding protein [KO:K15497] [EC:3.6.3.55 3.6.3.-]
Mlab_1062  Substrate-binding region of ABC-type glycine betaine transport system [KO:K02002]
Mlab_1061  binding-protein-dependent transport systems inner membrane component [KO:K02001]
Mlab_1060  glycine betaine/L-proline ABC transporter, ATPase subunit [KO:K02000] [EC:3.6.3.32]
Mlab_1118  phosphate binding protein [KO:K02040]
Mlab_1117  phosphate ABC transporter, inner membrane subunit PstA [KO:K02037 K02038]
Mlab_1116  phosphate ABC transporter, ATPase subunit [KO:K02036] [EC:3.6.3.27]
Mlab_1670  Extracellular ligand-binding receptor [KO:K01999]
Mlab_0168  oligopeptide/dipeptide ABC transporter, ATPase subunit [KO:K15583]
Mlab_0167  ABC transporter related protein [KO:K10823]
Mlab_1288  periplasmic binding protein [KO:K02016]
Mlab_1151  periplasmic binding protein [KO:K02016]
Mlab_1721  periplasmic binding protein [KO:K02016]
Mlab_1044  periplasmic binding protein [KO:K02016]
Mlab_1093  periplasmic binding protein [KO:K02016]
Mlab_1372  periplasmic binding protein [KO:K02016]
Mlab_1374  periplasmic binding protein [KO:K02016]
Mlab_0327  periplasmic binding protein [KO:K02016]
Mlab_1091  periplasmic binding protein [KO:K02016]
Mlab_1092  periplasmic binding protein [KO:K02016]
Mlab_1089  transport system permease protein [KO:K02015]
Mlab_1290  transport system permease protein [KO:K02015]
Mlab_1377  transport system permease protein [KO:K02015]
Mlab_1153  transport system permease protein [KO:K02015]
Mlab_1043  transport system permease protein [KO:K02015]
Mlab_1720  transport system permease protein [KO:K02015]
Mlab_1289  ABC transporter related protein [KO:K02013] [EC:3.6.3.34]
Mlab_1378  ABC transporter related protein [KO:K02013] [EC:3.6.3.34]
Mlab_1152  ABC transporter related protein [KO:K02013] [EC:3.6.3.34]
Mlab_1088  ABC transporter related protein [KO:K02013] [EC:3.6.3.34]
Mlab_1719  ABC transporter related protein [KO:K02013] [EC:3.6.3.34]
Mlab_1084  Cobalt transport protein CbiN [KO:K02009]
Mlab_1085  cobalamin biosynthesis protein CbiM [KO:K02007]
Mlab_1073  cobalamin biosynthesis protein CbiM [KO:K02007 K02008]
Mlab_0380  cobalamin biosynthesis protein CbiM [KO:K02007]
Mlab_1390  cobalt ABC transporter, inner membrane subunit CbiQ [KO:K02008]
Mlab_1074  cobalt ABC transporter, ATPase subunit [KO:K02006]
Mlab_1391  cobalt ABC transporter, ATPase subunit [KO:K02006]
Mlab_0132  BioY protein [KO:K03523]
Mlab_0027  cobalt transport protein [KO:K16785]
Mlab_0135  hypothetical protein [KO:K16785]
Mlab_0260  cobalt transport protein [KO:K16785]
Mlab_0133  ABC transporter related protein [KO:K16786] [EC:3.6.3.-]
Mlab_0026  ABC transporter related protein [KO:K16786 K16787] [EC:3.6.3.- 3.6.3.-]
Mlab_0259  ABC transporter related protein [KO:K16786 K16787] [EC:3.6.3.- 3.6.3.-]
Mlab_0134  ABC transporter related protein [KO:K16787] [EC:3.6.3.-]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00045  Amino acid
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00315  Spermidine
C00320  Thiosulfate
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00719  Betaine
C00753  Tungsten
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  D-Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06228  Ferrichrome
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06704  Iron chelate
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C16059  Defensin beta-1
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
D02224  Protamine sulfate (JP17/USP/INN)
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   

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