KEGG   PATHWAY: mmu00053Help
Entry
mmu00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Mus musculus (mouse)
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Ascorbate and aldarate metabolism
mmu00053

All organismsOrtholog table
Module
Ascorbate biosynthesis, plants, glucose-6P => ascorbate [PATH:mmu00053]
Ascorbate biosynthesis, animals, glucose-1P => ascorbate [PATH:mmu00053]
PTS system, ascorbate-specific II component [PATH:mmu00053]
Other DBs
BSID: 
GO: 
Organism
Mus musculus (mouse) [GN:mmu]
Gene
22235  
Ugdh; UDP-glucose dehydrogenase [KO:K00012] [EC:1.1.1.22]
22238  
Ugt2b5; UDP glucuronosyltransferase 2 family, polypeptide B5 [KO:K00699] [EC:2.4.1.17]
22236  
Ugt1a2; UDP glucuronosyltransferase 1 family, polypeptide A2 [KO:K00699] [EC:2.4.1.17]
94284  
Ugt1a6a; UDP glucuronosyltransferase 1 family, polypeptide A6A [KO:K00699] [EC:2.4.1.17]
94215  
Ugt2a1; UDP glucuronosyltransferase 2 family, polypeptide A1 [KO:K00699] [EC:2.4.1.17]
394434  
Ugt1a9; UDP glucuronosyltransferase 1 family, polypeptide A9 [KO:K00699] [EC:2.4.1.17]
394430  
Ugt1a10; UDP glycosyltransferase 1 family, polypeptide A10 [KO:K00699] [EC:2.4.1.17]
394432  
Ugt1a7c; UDP glucuronosyltransferase 1 family, polypeptide A7C [KO:K00699] [EC:2.4.1.17]
394433  
Ugt1a5; UDP glucuronosyltransferase 1 family, polypeptide A5 [KO:K00699] [EC:2.4.1.17]
72094  
Ugt2a3; UDP glucuronosyltransferase 2 family, polypeptide A3 [KO:K00699] [EC:2.4.1.17]
552899  
Ugt2a2; UDP glucuronosyltransferase 2 family, polypeptide A2 [KO:K00699] [EC:2.4.1.17]
71773  
Ugt2b1; UDP glucuronosyltransferase 2 family, polypeptide B1 [KO:K00699] [EC:2.4.1.17]
394435  
Ugt1a6b; UDP glucuronosyltransferase 1 family, polypeptide A6B [KO:K00699] [EC:2.4.1.17]
394436  
Ugt1a1; UDP glucuronosyltransferase 1 family, polypeptide A1 [KO:K00699] [EC:2.4.1.17]
100727  
Ugt2b34; UDP glucuronosyltransferase 2 family, polypeptide B34 [KO:K00699] [EC:2.4.1.17]
231396  
Ugt2b36; UDP glucuronosyltransferase 2 family, polypeptide B36 [KO:K00699] [EC:2.4.1.17]
100559  
Ugt2b38; UDP glucuronosyltransferase 2 family, polypeptide B38 [KO:K00699] [EC:2.4.1.17]
112417  
Ugt2b37; UDP glucuronosyltransferase 2 family, polypeptide B37 [KO:K00699] [EC:2.4.1.17]
243085  
Ugt2b35; UDP glucuronosyltransferase 2 family, polypeptide B35 [KO:K00699] [EC:2.4.1.17]
56727  
Miox; myo-inositol oxygenase [KO:K00469] [EC:1.13.99.1]
19733  
Rgn; regucalcin [KO:K01053] [EC:3.1.1.17]
268756  
Gulo; gulonolactone (L-) oxidase [KO:K00103] [EC:1.1.3.8]
11669  
Aldh2; aldehyde dehydrogenase 2, mitochondrial [KO:K00128] [EC:1.2.1.3]
11671  
Aldh3a2; aldehyde dehydrogenase family 3, subfamily A2 [KO:K00128] [EC:1.2.1.3]
72535  
Aldh1b1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
110695  
Aldh7a1; aldehyde dehydrogenase family 7, member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
56752  
Aldh9a1; aldehyde dehydrogenase 9, subfamily A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]
Compound
C00022  
Pyruvate
C00026  
2-Oxoglutarate
C00029  
UDP-glucose
C00072  
Ascorbate
C00096  
GDP-mannose
C00137  
myo-Inositol
C00167  
UDP-glucuronate
C00191  
D-Glucuronate
C00231  
D-Xylulose 5-phosphate
C00259  
L-Arabinose
C00333  
D-Galacturonate
C00433  
2,5-Dioxopentanoate
C00545  
L-Arabinonate
C00618  
3-Dehydro-L-gulonate
C00679  
5-Dehydro-4-deoxy-D-glucarate
C00684  
2-Dehydro-3-deoxy-L-arabinonate
C00800  
L-Gulonate
C00818  
D-Glucarate
C00879  
D-Galactarate
C01040  
L-Gulono-1,4-lactone
C01041  
Monodehydroascorbate
C01101  
L-Ribulose 5-phosphate
C01114  
L-Arabinono-1,4-lactone
C01115  
L-Galactono-1,4-lactone
C01146  
2-Hydroxy-3-oxopropanoate
C01620  
Threonate
C01825  
L-Galactose
C02280  
GDP-L-galactose
C02670  
D-Glucuronolactone
C03064  
3-Dehydro-L-threonate
C03289  
L-xylo-Hexulonolactone
C03291  
L-Xylulose 5-phosphate
C03826  
2-Dehydro-3-deoxy-D-xylonate
C03921  
2-Dehydro-3-deoxy-D-glucarate
C04575  
(4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  
D-Glucuronate 1-phosphate
C05406  
5-Hydroxy-2,4-dioxopentanoate
C05411  
L-Xylonate
C05412  
L-Lyxonate
C05422  
Dehydroascorbate
C14899  
3-Dehydro-L-gulonate 6-phosphate
C15923  
L-Gulose
C15924  
L-Gulose 1-phosphate
C15925  
GDP-L-gulose
C15926  
L-Galactose 1-phosphate
C15930  
L-Galactonate
C16186  
L-Ascorbate 6-phosphate
Reference
  Authors
Linster CL, Van Schaftingen E.
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
Reference
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
Reference
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
Reference
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
Reference
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
Reference
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
Reference
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
KO pathway
 
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