KEGG   PATHWAY: mmu00514Help
Entry
mmu00514                    Pathway                                
Name
Other types of O-glycan biosynthesis - Mus musculus (mouse)
Description
O-mannosyl glycans are a type of O-glycans that are found both in eukaryotes and prokaryotes. Biosynthesis of O-mannosyl glycans is initiated by the transfer of mannose from Man-P-Dol to serine or threonine residue, which is catalyzed by protein O-mannosyltransferases POMT1 and POMT2. Defects of these genes are linked to human diseases, such as muscular dystrophies caused by reduced O-mannosylation of alpha-dystroglycan in skeletal muscles [DS:H00120].
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
Other types of O-glycan biosynthesis
mmu00514

All organismsOrtholog table
Organism
Mus musculus (mouse) [GN:mmu]
Gene
99011  
Pomt1; protein-O-mannosyltransferase 1 [KO:K00728] [EC:2.4.1.109]
217734  
Pomt2; protein-O-mannosyltransferase 2 [KO:K00728] [EC:2.4.1.109]
68273  
Pomgnt1; protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase [KO:K09666] [EC:2.4.1.-]
14595  
B4galt1; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 [KO:K07966] [EC:2.4.1.- 2.4.1.38 2.4.1.90 2.4.1.22]
53418  
B4galt2; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 [KO:K07967] [EC:2.4.1.- 2.4.1.38 2.4.1.90 2.4.1.22]
57370  
B4galt3; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 [KO:K07968] [EC:2.4.1.- 2.4.1.38 2.4.1.90]
20441  
St3gal3; ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [KO:K00781] [EC:2.4.99.6]
14348  
Fut9; fucosyltransferase 9 [KO:K03663] [EC:2.4.1.152]
14345  
Fut4; fucosyltransferase 4 [KO:K07632] [EC:2.4.1.-]
14347  
Fut7; fucosyltransferase 7 [KO:K07635] [EC:2.4.1.-]
268510  
Mgat5b; mannoside acetylglucosaminyltransferase 5, isoenzyme B [KO:K09661] [EC:2.4.1.-]
54218  
B3galt4; UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 [KO:K00715] [EC:2.4.1.62]
76898  
B3gat1; beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) [KO:K00735] [EC:2.4.1.135]
280645  
B3gat2; beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) [KO:K10157] [EC:2.4.1.135]
98388  
Chst10; carbohydrate sulfotransferase 10 [KO:K09674] [EC:2.8.2.-]
108155  
Ogt; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) [KO:K09667] [EC:2.4.1.-]
140484  
Pofut1; protein O-fucosyltransferase 1 [KO:K03691] [EC:2.4.1.221]
80294  
Pofut2; protein O-fucosyltransferase 2 [KO:K03691] [EC:2.4.1.221]
16848  
Lfng; LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [KO:K05948] [EC:2.4.1.222]
17305  
Mfng; MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [KO:K05948] [EC:2.4.1.222]
19719  
Rfng; RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [KO:K05948] [EC:2.4.1.222]
20440  
St6gal1; beta galactoside alpha 2,6 sialyltransferase 1 [KO:K00778] [EC:2.4.99.1]
240119  
St6gal2; beta galactoside alpha 2,6 sialyltransferase 2 [KO:K00779] [EC:2.4.99.1]
381694  
B3galtl; beta 1,3-galactosyltransferase-like [KO:K13675] [EC:2.4.1.-]
224143  
Poglut1; protein O-glucosyltransferase 1 [KO:K13667] [EC:2.4.1.-]
223827  
Gxylt1; glucoside xylosyltransferase 1 [KO:K13676] [EC:2.4.2.-]
232313  
Gxylt2; glucoside xylosyltransferase 2 [KO:K13676] [EC:2.4.2.-]
234407  
Glt25d1; glycosyltransferase 25 domain containing 1 [KO:K11703] [EC:2.4.1.50]
269132  
Colgalt2; collagen beta(1-O)galactosyltransferase 2 [KO:K11703] [EC:2.4.1.50]
26433  
Plod3; procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 [KO:K13646] [EC:2.4.1.66 2.4.1.50 1.14.11.4]
Reference
  Authors
Kizuka Y, Oka S
  Title
Regulated expression and neural functions of human natural killer-1 (HNK-1) carbohydrate.
  Journal
Cell Mol Life Sci 69:4135-47 (2012)
Reference
  Authors
Lommel M, Strahl S
  Title
Protein O-mannosylation: conserved from bacteria to humans.
  Journal
Glycobiology 19:816-28 (2009)
KO pathway
 
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