KEGG   PATHWAY: mmu00830
Entry
mmu00830                    Pathway                                
Name
Retinol metabolism - Mus musculus (house mouse)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
mmu00830  Retinol metabolism
mmu00830

Other DBs
GO: 0006776
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
63857  Bco1; beta-carotene oxygenase 1 [KO:K00515] [EC:1.13.11.63]
11522  Adh1; alcohol dehydrogenase 1 (class I) [KO:K13951] [EC:1.1.1.1]
11529  Adh7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
26876  Adh4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
11532  Adh5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
20148  Dhrs3; dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
28200  Dhrs4; dehydrogenase/reductase 4 [KO:K11147] [EC:1.1.-.-]
241452  Dhrs9; dehydrogenase/reductase 9 [KO:K11149] [EC:1.1.-.-]
235033  Rdh8; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
98711  Rdh10; retinol dehydrogenase 10 (all-trans) [KO:K11151] [EC:1.1.1.-]
17252  Rdh11; retinol dehydrogenase 11 [KO:K11152] [EC:1.1.1.300]
77974  Rdh12; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
108841  Rdh13; retinol dehydrogenase 13 (all-trans and 9-cis) [KO:K11161] [EC:1.1.1.300]
216453  Rdh19; retinol dehydrogenase 19 [KO:K11154] [EC:1.1.1.-]
216454  Rdh16f2; RDH16 family member 2 [KO:K11154] [EC:1.1.1.-]
19683  Rdh16; retinol dehydrogenase 16 [KO:K11154] [EC:1.1.1.-]
103142  Rdh9; retinol dehydrogenase 9 [KO:K11154] [EC:1.1.1.-]
107605  Rdh1; retinol dehydrogenase 1 (all trans) [KO:K11154] [EC:1.1.1.-]
54150  Rdh7; retinol dehydrogenase 7 [KO:K11154] [EC:1.1.1.-]
242285  Sdr16c5; short chain dehydrogenase/reductase family 16C, member 5 [KO:K15734] [EC:1.1.1.105]
27400  Hsd17b6; hydroxysteroid (17-beta) dehydrogenase 6 [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
79235  Lrat; lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) [KO:K00678] [EC:2.3.1.135]
13350  Dgat1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
245532  Awat2; acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.75 2.3.1.76]
19892  Rpe65; retinal pigment epithelium 65 [KO:K11158] [EC:3.1.1.64 5.3.3.22]
19682  Rdh5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
213043  Aox2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
11761  Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
71872  Aox4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
71724  Aox3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
26358  Aldh1a7; aldehyde dehydrogenase family 1, subfamily A7 [KO:K07249] [EC:1.2.1.36]
19378  Aldh1a2; aldehyde dehydrogenase family 1, subfamily A2 [KO:K07249] [EC:1.2.1.36]
11668  Aldh1a1; aldehyde dehydrogenase family 1, subfamily A1 [KO:K07249] [EC:1.2.1.36]
56847  Aldh1a3; aldehyde dehydrogenase family 1, subfamily A3 [KO:K07249] [EC:1.2.1.36]
13082  Cyp26a1; cytochrome P450, family 26, subfamily a, polypeptide 1 [KO:K07437] [EC:1.14.14.-]
232174  Cyp26b1; cytochrome P450, family 26, subfamily b, polypeptide 1 [KO:K12664] [EC:1.14.14.-]
546726  Cyp26c1; cytochrome P450, family 26, subfamily c, polypeptide 1 [KO:K12665] [EC:1.14.14.-]
13076  Cyp1a1; cytochrome P450, family 1, subfamily a, polypeptide 1 [KO:K07408] [EC:1.14.14.1]
13077  Cyp1a2; cytochrome P450, family 1, subfamily a, polypeptide 2 [KO:K07409] [EC:1.14.14.1]
13086  Cyp2a4; cytochrome P450, family 2, subfamily a, polypeptide 4 [KO:K07411] [EC:1.14.14.1]
13087  Cyp2a5; cytochrome P450, family 2, subfamily a, polypeptide 5 [KO:K07411] [EC:1.14.14.1]
13085  Cyp2a12; cytochrome P450, family 2, subfamily a, polypeptide 12 [KO:K07411] [EC:1.14.14.1]
233005  Cyp2a22; cytochrome P450, family 2, subfamily a, polypeptide 22 [KO:K07411] [EC:1.14.14.1]
13088  Cyp2b10; cytochrome P450, family 2, subfamily b, polypeptide 10 [KO:K07412] [EC:1.14.14.1]
13089  Cyp2b13; cytochrome P450, family 2, subfamily b, polypeptide 13 [KO:K07412] [EC:1.14.14.1]
13090  Cyp2b19; cytochrome P450, family 2, subfamily b, polypeptide 19 [KO:K07412] [EC:1.14.14.1]
13094  Cyp2b9; cytochrome P450, family 2, subfamily b, polypeptide 9 [KO:K07412] [EC:1.14.14.1]
243881  Cyp2b23; cytochrome P450, family 2, subfamily b, polypeptide 23 [KO:K07412] [EC:1.14.14.1]
13097  Cyp2c38; cytochrome P450, family 2, subfamily c, polypeptide 38 [KO:K07413] [EC:1.14.14.1]
13098  Cyp2c39; cytochrome P450, family 2, subfamily c, polypeptide 39 [KO:K07413] [EC:1.14.14.1]
13099  Cyp2c40; cytochrome P450, family 2, subfamily c, polypeptide 40 [KO:K07413] [EC:1.14.14.1]
226143  Cyp2c23; cytochrome P450, family 2, subfamily c, polypeptide 23 [KO:K07413] [EC:1.14.14.1]
13095  Cyp2c29; cytochrome P450, family 2, subfamily c, polypeptide 29 [KO:K07413] [EC:1.14.14.1]
226105  Cyp2c70; cytochrome P450, family 2, subfamily c, polypeptide 70 [KO:K07413] [EC:1.14.14.1]
13096  Cyp2c37; cytochrome P450, family 2. subfamily c, polypeptide 37 [KO:K07413] [EC:1.14.14.1]
72082  Cyp2c55; cytochrome P450, family 2, subfamily c, polypeptide 55 [KO:K07413] [EC:1.14.14.1]
72303  Cyp2c65; cytochrome P450, family 2, subfamily c, polypeptide 65 [KO:K07413] [EC:1.14.14.1]
69888  Cyp2c66; cytochrome P450, family 2, subfamily c, polypeptide 66 [KO:K07413] [EC:1.14.14.1]
107141  Cyp2c50; cytochrome P450, family 2, subfamily c, polypeptide 50 [KO:K07413] [EC:1.14.14.1]
404195  Cyp2c54; cytochrome P450, family 2, subfamily c, polypeptide 54 [KO:K07413] [EC:1.14.14.1]
433247  Cyp2c68; cytochrome P450, family 2, subfamily c, polypeptide 68 [KO:K07413] [EC:1.14.14.1]
100043108  Cyp2c69; cytochrome P450, family 2, subfamily c, polypeptide 69 [KO:K07413] [EC:1.14.14.1]
545288  Cyp2c67; cytochrome P450, family 2, subfamily c, polypeptide 67 [KO:K07413] [EC:1.14.14.1]
74134  Cyp2s1; cytochrome P450, family 2, subfamily s, polypeptide 1 [KO:K07420] [EC:1.14.14.1]
13112  Cyp3a11; cytochrome P450, family 3, subfamily a, polypeptide 11 [KO:K07424] [EC:1.14.14.1]
13113  Cyp3a13; cytochrome P450, family 3, subfamily a, polypeptide 13 [KO:K07424] [EC:1.14.14.1]
13114  Cyp3a16; cytochrome P450, family 3, subfamily a, polypeptide 16 [KO:K07424] [EC:1.14.14.1]
56388  Cyp3a25; cytochrome P450, family 3, subfamily a, polypeptide 25 [KO:K07424] [EC:1.14.14.1]
53973  Cyp3a41a; cytochrome P450, family 3, subfamily a, polypeptide 41A [KO:K07424] [EC:1.14.14.1]
337924  Cyp3a44; cytochrome P450, family 3, subfamily a, polypeptide 44 [KO:K07424] [EC:1.14.14.1]
100041375  Cyp3a41b; cytochrome P450, family 3, subfamily a, polypeptide 41B [KO:K07424] [EC:1.14.14.1]
100041449  Cyp3a59; cytochrome P450, family 3, subfamily a, polypeptide 59 [KO:K07424] [EC:1.14.14.1]
622127  Cyp3a57; cytochrome P450, family 3, subfamily a, polypeptide 57 [KO:K07424] [EC:1.14.14.1]
545817  Cyp2w1; cytochrome P450, family 2, subfamily w, polypeptide 1 [KO:K07423] [EC:1.14.14.-]
13118  Cyp4a12b; cytochrome P450, family 4, subfamily a, polypeptide 12B [KO:K07425] [EC:1.14.14.80]
13117  Cyp4a10; cytochrome P450, family 4, subfamily a, polypeptide 10 [KO:K07425] [EC:1.14.14.80]
13119  Cyp4a14; cytochrome P450, family 4, subfamily a, polypeptide 14 [KO:K07425] [EC:1.14.14.80]
435802  Cyp4a30b; cytochrome P450, family 4, subfamily a, polypeptide 30b [KO:K07425] [EC:1.14.14.80]
230639  Cyp4a29; cytochrome P450, family 4, subfamily a, polypeptide 29 [KO:K07425] [EC:1.14.14.80]
666168  Cyp4a31; cytochrome P450, family 4, subfamily a, polypeptide 31 [KO:K07425] [EC:1.14.14.80]
100040843  Cyp4a32; cytochrome P450, family 4, subfamily a, polypeptide 32 [KO:K07425] [EC:1.14.14.80]
277753  Cyp4a12a; cytochrome P450, family 4, subfamily a, polypeptide 12a [KO:K07425] [EC:1.14.14.80]
22238  Ugt2b5; UDP glucuronosyltransferase 2 family, polypeptide B5 [KO:K00699] [EC:2.4.1.17]
22236  Ugt1a2; UDP glucuronosyltransferase 1 family, polypeptide A2 [KO:K00699] [EC:2.4.1.17]
94284  Ugt1a6a; UDP glucuronosyltransferase 1 family, polypeptide A6A [KO:K00699] [EC:2.4.1.17]
94215  Ugt2a1; UDP glucuronosyltransferase 2 family, polypeptide A1 [KO:K00699] [EC:2.4.1.17]
394434  Ugt1a9; UDP glucuronosyltransferase 1 family, polypeptide A9 [KO:K00699] [EC:2.4.1.17]
394430  Ugt1a10; UDP glycosyltransferase 1 family, polypeptide A10 [KO:K00699] [EC:2.4.1.17]
394432  Ugt1a7c; UDP glucuronosyltransferase 1 family, polypeptide A7C [KO:K00699] [EC:2.4.1.17]
394433  Ugt1a5; UDP glucuronosyltransferase 1 family, polypeptide A5 [KO:K00699] [EC:2.4.1.17]
72094  Ugt2a3; UDP glucuronosyltransferase 2 family, polypeptide A3 [KO:K00699] [EC:2.4.1.17]
552899  Ugt2a2; UDP glucuronosyltransferase 2 family, polypeptide A2 [KO:K00699] [EC:2.4.1.17]
71773  Ugt2b1; UDP glucuronosyltransferase 2 family, polypeptide B1 [KO:K00699] [EC:2.4.1.17]
394435  Ugt1a6b; UDP glucuronosyltransferase 1 family, polypeptide A6B [KO:K00699] [EC:2.4.1.17]
394436  Ugt1a1; UDP glucuronosyltransferase 1 family, polypeptide A1 [KO:K00699] [EC:2.4.1.17]
100727  Ugt2b34; UDP glucuronosyltransferase 2 family, polypeptide B34 [KO:K00699] [EC:2.4.1.17]
231396  Ugt2b36; UDP glucuronosyltransferase 2 family, polypeptide B36 [KO:K00699] [EC:2.4.1.17]
100559  Ugt2b38; UDP glucuronosyltransferase 2 family, polypeptide B38 [KO:K00699] [EC:2.4.1.17]
112417  Ugt2b37; UDP glucuronosyltransferase 2 family, polypeptide B37 [KO:K00699] [EC:2.4.1.17]
243085  Ugt2b35; UDP glucuronosyltransferase 2 family, polypeptide B35 [KO:K00699] [EC:2.4.1.17]
613123  Ugt1a8; UDP glucuronosyltransferase 1 family, polypeptide A8 [KO:K00699] [EC:2.4.1.17]
67442  Retsat; retinol saturase (all trans retinol 13,14 reductase) [KO:K09516] [EC:1.3.99.23]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   

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Genome (1)   
   KEGG GENOME (1)   
Gene (102)   
   KEGG GENES (102)   
All databases (103)   

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