KEGG   PATHWAY: mmu03060Help
Entry
mmu03060                    Pathway                                

Name
Protein export - Mus musculus (mouse)
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
Protein export
mmu03060

All organismsOrtholog table
Module
Sec61 complex [PATH:mmu03060]
Other DBs
BSID: 
GO: 
Organism
Mus musculus (mouse) [GN:mmu]
Gene
69089  
Oxa1l; oxidase assembly 1-like [KO:K03217]
24067  
Srp54a; signal recognition particle 54A [KO:K03106] [EC:3.6.5.4]
665155  
Srp54b; signal recognition particle 54B [KO:K03106] [EC:3.6.5.4]
Srp54c; signal recognition particle 54C [KO:K03106] [EC:3.6.5.4]
53421  
Sec61a1; Sec61 alpha 1 subunit (S. cerevisiae) [KO:K10956]
57743  
Sec61a2; Sec61, alpha subunit 2 (S. cerevisiae) [KO:K10956]
66212  
Sec61b; Sec61 beta subunit [KO:K09481]
20335  
Sec61g; SEC61, gamma subunit [KO:K07342]
Gm15266; predicted gene 15266 [KO:K07342]
Gm4184; predicted gene 4184 [KO:K07342]
protein transport protein Sec61 subunit gamma [KO:K07342]
69276  
Sec62; SEC62 homolog (S. cerevisiae) [KO:K12275]
140740  
Sec63; SEC63-like (S. cerevisiae) [KO:K09540]
14828  
Hspa5; heat shock protein 5 [KO:K09490]
27058  
Srp9; signal recognition particle 9 [KO:K03109]
20813  
Srp14; signal recognition particle 14 [KO:K03104]
66661  
Srp72; signal recognition particle 72 [KO:K03108]
217337  
Srp68; signal recognition particle 68 [KO:K03107]
66384  
Srp19; signal recognition particle 19 [KO:K03105]
67398  
Srpr; signal recognition particle receptor ('docking protein') [KO:K13431]
20818  
Srprb; signal recognition particle receptor, B subunit [KO:K12272]
69019  
Spcs1; signal peptidase complex subunit 1 homolog (S. cerevisiae) [KO:K12946] [EC:3.4.-.-]
66624  
Spcs2; signal peptidase complex subunit 2 homolog (S. cerevisiae) [KO:K12947] [EC:3.4.-.-]
76687  
Spcs3; signal peptidase complex subunit 3 homolog (S. cerevisiae) [KO:K12948] [EC:3.4.-.-]
76219  
Arxes1; adipocyte-related X-chromosome expressed sequence 1 [KO:K12948] [EC:3.4.-.-]
76976  
Arxes2; adipocyte-related X-chromosome expressed sequence 2 [KO:K12948] [EC:3.4.-.-]
66286  
Sec11c; SEC11 homolog C, signal peptidase complex subunit [KO:K13280] [EC:3.4.-.-]
56529  
Sec11a; SEC11 homolog A, signal peptidase complex subunit [KO:K13280] [EC:3.4.-.-]
66541  
Immp1l; IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) [KO:K09647] [EC:3.4.21.-]
93757  
Immp2l; IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) [KO:K09648] [EC:3.4.21.-]
Reference
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4
Reference
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x
Reference
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200
Reference
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001
Reference
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214
Reference
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y
Reference
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4
Reference
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
 

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