KEGG   PATHWAY: mmu03410Help
Entry
mmu03410                    Pathway                                

Name
Base excision repair - Mus musculus (mouse)
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Base excision repair
mmu03410

All organismsOrtholog table
Module
DNA polymerase delta complex [PATH:mmu03410]
BER complex [PATH:mmu03410]
Other DBs
Organism
Mus musculus (mouse) [GN:mmu]
Gene
18294  
Ogg1; 8-oxoguanine DNA-glycosylase 1 [KO:K03660] [EC:4.2.99.18 3.2.2.-]
18207  
Nthl1; nth (endonuclease III)-like 1 (E.coli) [KO:K10773] [EC:4.2.99.18]
72774  
Neil1; nei endonuclease VIII-like 1 (E. coli) [KO:K10567] [EC:4.2.99.18 3.2.2.-]
382913  
Neil2; nei like 2 (E. coli) [KO:K10568] [EC:4.2.99.18 3.2.2.-]
234258  
Neil3; nei like 3 (E. coli) [KO:K10569]
22256  
Ung; uracil DNA glycosylase [KO:K03648] [EC:3.2.2.27]
71726  
Smug1; single-strand selective monofunctional uracil DNA glycosylase [KO:K10800] [EC:3.2.2.-]
70603  
Mutyh; mutY DNA glycosylase [KO:K03575] [EC:3.2.2.-]
268395  
Mpg; N-methylpurine-DNA glycosylase [KO:K03652] [EC:3.2.2.21]
17193  
Mbd4; methyl-CpG binding domain protein 4 [KO:K10801] [EC:3.2.2.-]
21665  
Tdg; thymine DNA glycosylase [KO:K20813] [EC:3.2.2.29]
545124  
Tdg-ps; thymine DNA glycosylase, pseudogene [KO:K20813] [EC:3.2.2.29]
11792  
Apex1; apurinic/apyrimidinic endonuclease 1 [KO:K10771] [EC:4.2.99.18]
77622  
Apex2; apurinic/apyrimidinic endonuclease 2 [KO:K10772] [EC:4.2.99.18]
18970  
Polb; polymerase (DNA directed), beta [KO:K02330] [EC:4.2.99.- 2.7.7.7]
56626  
Poll; polymerase (DNA directed), lambda [KO:K03512] [EC:4.2.99.- 2.7.7.7]
15289  
Hmgb1; high mobility group box 1 [KO:K10802]
Gm21596; predicted gene, 21596 [KO:K10802]
22594  
Xrcc1; X-ray repair complementing defective repair in Chinese hamster cells 1 [KO:K10803]
18538  
Pcna; proliferating cell nuclear antigen [KO:K04802]
18971  
Pold1; polymerase (DNA directed), delta 1, catalytic subunit [KO:K02327] [EC:2.7.7.7]
18972  
Pold2; polymerase (DNA directed), delta 2, regulatory subunit [KO:K02328]
67967  
Pold3; polymerase (DNA-directed), delta 3, accessory subunit [KO:K03504]
69745  
Pold4; polymerase (DNA-directed), delta 4 [KO:K03505]
18973  
Pole; polymerase (DNA directed), epsilon [KO:K02324] [EC:2.7.7.7]
18974  
Pole2; polymerase (DNA directed), epsilon 2 (p59 subunit) [KO:K02325] [EC:2.7.7.7]
59001  
Pole3; polymerase (DNA directed), epsilon 3 (p17 subunit) [KO:K02326] [EC:2.7.7.7]
66979  
Pole4; polymerase (DNA-directed), epsilon 4 (p12 subunit) [KO:K03506] [EC:2.7.7.7]
16881  
Lig1; ligase I, DNA, ATP-dependent [KO:K10747] [EC:6.5.1.7 6.5.1.6 6.5.1.1]
16882  
Lig3; ligase III, DNA, ATP-dependent [KO:K10776] [EC:6.5.1.1]
11546  
Parp2; poly (ADP-ribose) polymerase family, member 2 [KO:K10798] [EC:2.4.2.30]
11545  
Parp1; poly (ADP-ribose) polymerase family, member 1 [KO:K10798] [EC:2.4.2.30]
235587  
Parp3; poly (ADP-ribose) polymerase family, member 3 [KO:K10798] [EC:2.4.2.30]
328417  
Parp4; poly (ADP-ribose) polymerase family, member 4 [KO:K10798] [EC:2.4.2.30]
14156  
Fen1; flap structure specific endonuclease 1 [KO:K04799] [EC:3.-.-.-]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP,  into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
 

DBGET integrated database retrieval system